Effexor and Hypertonia - a phase IV clinical study of FDA data

• Effexor (95,259 reports)

• Abasia (inability to walk): 314 reports
• Abdominal discomfort: 975 reports
• Abdominal distension: 693 reports
• Abdominal pain: 2,103 reports
• Abdominal pain lower: 173 reports
• Abdominal pain upper: 1,319 reports
• Abnormal behavior: 847 reports
• Abnormal dreams: 765 reports
• Abortion spontaneous (naturally occurring miscarriage): 308 reports
• Abscess (pus): 184 reports
• Accident: 131 reports
• Accidental overdose (therapeutic agent): 239 reports
• Acne (skin problems that cause pimples): 242 reports
• Actinomycosis (infection that causes sores, or abscesses): 120 reports
• Activities of daily living impaired: 573 reports
• Acute kidney failure: 1,029 reports
• Acute myocardial infarction (acute heart attack): 157 reports
• Acute respiratory failure: 128 reports
• Acute upper airway obstruction (blockage occurs in the upper airway): 126 reports
• Adverse drug reaction: 260 reports
• Adverse event: 278 reports
• Affective disorder (mental disorder): 184 reports
• Affect lability (emotional incontinence): 205 reports
• Ageusia (loss of taste functions of the tongue): 127 reports
• Aggression: 1,059 reports
• Agitation (state of anxiety or nervous excitement): 2,389 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 545 reports
• Akathisia (a movement disorder characterized by a feeling of inner restlessness): 218 reports
• Alanine aminotransferase increased: 528 reports
• Alcoholism (problems with alcohol): 340 reports
• Allergic rhinitis: 171 reports
• Altered state of consciousness (altered state of mind): 175 reports
• Anaemia (lack of blood): 1,554 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 197 reports
• Anger: 1,027 reports
• Angioedema (rapid swelling of the dermis): 169 reports
• Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes): 108 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 605 reports
• Ankle fracture: 270 reports
• Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 401 reports
• Aortic valve incompetence: 161 reports
• Apathy: 454 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 1,537 reports
• Appetite disorder (abnormal eating habits): 140 reports
• Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 402 reports
• Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system): 142 reports
• Arrhythmias (irregular heartbeat): 987 reports
• Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery): 142 reports
• Arthritis (form of joint disorder that involves inflammation of one or more joints): 855 reports
• Arthropathy: 484 reports
• Ascites (accumulation of fluid in the abdominal cavity): 164 reports
• Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 518 reports
• Aspartate aminotransferase increased: 490 reports
• Aspiration: 117 reports
• Asthma: 827 reports
• Atelectasis (partial or complete collapse of the lung): 510 reports
• Atherosclerosis (disorder of the arteries): 240 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 657 reports
• Atrial septal defect (an abnormal opening between the left and right atria of the heart): 257 reports
• Atrioventricular block first degree (heart block first degree): 101 reports
• Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 133 reports
• Back disorder: 229 reports
• Back injury: 181 reports
• Back pain: 2,513 reports
• Bacterial infection: 226 reports
• Balance disorder: 1,010 reports
• Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills): 121 reports
• Bedridden: 179 reports
• Belching (release of gas from the digestive tract): 114 reports
• Bell's palsy (facial paralysis): 112 reports
• Bipolar disorder (mood disorder): 497 reports
• Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode): 135 reports
• Birth control: 238 reports
• Bladder disorder: 113 reports
• Bleeding disorders: 103 reports
• Blindness: 212 reports
• Blindness unilateral: 104 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 229 reports
• Blood albumin decreased: 120 reports
• Blood alkaline phosphatase increased: 251 reports
• Blood bilirubin increased: 174 reports
• Blood calcium decreased: 138 reports
• Blood creatine phosphokinase increased: 374 reports
• Blood creatinine increased: 325 reports
• Blood glucose decreased: 223 reports
• Blood glucose increased: 750 reports
• Blood potassium decreased: 302 reports
• Blood pressure fluctuation: 255 reports
• Blood pressure management: 175 reports
• Blood pressure systolic increased: 221 reports
• Blood sodium decreased: 192 reports
• Blood urea increased: 151 reports
• Blood urine present: 119 reports
• Body height decreased: 108 reports
• Body temperature decreased: 143 reports
• Body temperature increased: 184 reports
• Bone density decreased: 160 reports
• Bone disorder: 813 reports
• Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 182 reports
• Bone pain: 622 reports
• Bradycardia (abnormally slow heart action): 267 reports
• Breast cancer: 344 reports
• Breast cancer female: 150 reports
• Breast cancer metastatic: 113 reports
• Breast pain: 175 reports
• Breathing difficulty: 3,818 reports
• Breathing - slowed or stopped: 115 reports
• Broken bone: 173 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 973 reports
• Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 114 reports
• Bruxism (habitual grinding of the teeth, typically during sleep): 216 reports
• Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle): 153 reports
• Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle): 112 reports
• Burning sensation: 498 reports
• Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 266 reports
• Candidiasis (candidiasis or thrush is a fungal infection): 136 reports
• Cardiac arrest: 554 reports
• Cardiac disorder: 650 reports
• Cardiac failure: 405 reports
• Cardiac failure congestive: 926 reports
• Cardiac murmur (an heart sound in valve abnormality): 233 reports
• Cardiomyopathy (weakening of the heart muscle): 281 reports
• Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 196 reports
• Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 283 reports
• Cataplexy (loss of muscle tone accompanied by full conscious awareness): 111 reports
• Cataract (clouding of the lens inside the eye): 518 reports
• Cellulitis (infection under the skin): 661 reports
• Central nervous system lesion (an abnormality in tissue of brain or spinal cord): 126 reports
• Cerebral atrophy (decrement in size of brain): 130 reports
• Cerebral disorder (brain disease): 108 reports
• Cerebral haemorrhage (bleeding within the brain): 145 reports
• Cerebral infarction (less blood supply to brain resulting tissue damage): 106 reports
• Chest pain: 2,830 reports
• Chills (felling of cold): 1,031 reports
• Cholecystitis (infection of gallbladder): 182 reports
• Cholecystitis acute (rapid infection of gallbladder): 127 reports
• Cholecystitis chronic (long lasting infection of gallbladder): 250 reports
• Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 136 reports
• Chronic kidney disease: 534 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 649 reports
• Circulatory collapse: 175 reports
• Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 521 reports
• Colitis (inflammation of colon): 266 reports
• Colonic polyp (extra part of colon tissue grow in intestine): 133 reports
• Common peroneal nerve dysfunction (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes): 123 reports
• Completed suicide (act of taking one's own life): 789 reports
• Complications of maternal exposure to therapeutic drugs: 134 reports
• Compression fracture (fracture due to pressure caused by injury): 172 reports
• Concussion (short loss of normal brain function in response to a head injury): 199 reports
• Condition: 2,401 reports
• Confusion: 1,025 reports
• Confusional state: 2,241 reports
• Congenital anomaly (birth defect): 162 reports
• Congestive cardiomyopathy (weakening of heart muscle): 114 reports
• Conjunctivitis (pink eye): 116 reports
• Consciousness - decreased: 544 reports
• Constipation: 2,093 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1,294 reports
• Coronary artery occlusion (complete obstruction of blood flow in a coronary artery): 177 reports
• Coronary heart disease (narrowing or blockage of the coronary arteries): 453 reports
• Cough: 1,670 reports
• Coughing up blood: 209 reports
• C-reactive protein increased: 188 reports
• Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 404 reports
• Crying: 1,459 reports
• Cuts and puncture wounds: 240 reports
• Cyst (a closed sac): 250 reports
• Cytolytic hepatitis (dissolution or destruction of a liver cell): 114 reports
• Death: 1,206 reports
• Decreased activity: 110 reports
• Decreased interest: 554 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 847 reports
• Deformity (disfigurement): 346 reports
• Dehydration (dryness resulting from the removal of water): 1,373 reports
• Delirium (wild excitement): 348 reports
• Delusion (a false belief or opinion): 233 reports
• Dementia (madness): 176 reports
• Dental caries: 365 reports
• Dependence: 133 reports
• Depersonalisation: 102 reports
• Depressed level of consciousness: 434 reports
• Depressed mood: 916 reports
• Depression: 6,358 reports
• Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 282 reports
• Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens): 101 reports
• Developmental delay: 110 reports
• Device related infection: 139 reports
• Diabetes: 1,754 reports
• Diabetes mellitus inadequate control: 313 reports
• Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 380 reports
• Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus): 325 reports
• Diarrhea: 3,660 reports
• Difficulty in walking: 181 reports
• Diplopia (double vision): 274 reports
• Disability: 249 reports
• Discomfort: 311 reports
• Disease progression: 273 reports
• Disease recurrence: 176 reports
• Dissociation: 113 reports
• Disturbance in attention: 1,290 reports
• Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 182 reports
• Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 283 reports
• Diverticulum intestinal (a pouch that is attached to the first part of the small intestine): 126 reports
• Dizziness: 5,724 reports
• Dizziness (excl vertigo): 106 reports
• Drowsiness: 2,869 reports
• Drug abuse and dependence: 530 reports
• Drug administration error: 130 reports
• Drug dependence: 1,202 reports
• Drug effect decreased: 647 reports
• Drug exposure during pregnancy: 1,178 reports
• Drug hypersensitivity: 2,065 reports
• Drug ineffective: 5,736 reports
• Drug intolerance (drug sensitivity): 437 reports
• Drug level increased: 106 reports
• Drug screen positive: 190 reports
• Drug toxicity: 341 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 5,117 reports
• Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother): 135 reports
• Dry eyes (lack of adequate tears): 291 reports
• Dry mouth: 1,063 reports
• Dry skin: 310 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 609 reports
• Dyspnea exertional: 371 reports
• Dysstasia (difficulty in standing): 325 reports
• Ear pain: 326 reports
• Eating disorder: 305 reports
• Ecchymosis (a discoloration of the skin resulting from bleeding underneath): 213 reports
• Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 229 reports
• Ejaculation disorder: 122 reports
• Ejection fraction decreased (systolic heart failure): 171 reports
• Electrocardiogram qt prolonged: 277 reports
• Emotional disorder: 649 reports
• Emotional distress: 1,138 reports
• Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 233 reports
• Encephalopathy (functioning of the brain is affected by some agent or condition): 179 reports
• Enlarged heart: 419 reports
• Enlarged prostate: 104 reports
• Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 220 reports
• Erection problems: 601 reports
• Erythema multiforme (a type of hypersensitivity reaction): 227 reports
• Euphoric mood (excessively happy but may become angry or irritable): 187 reports
• Excoriation (to tear or wear off the skin of): 107 reports
• Exostosis (formation of new bone on the surface of a bone): 238 reports
• Exposed bone in jaw: 131 reports
• Extrapyramidal disorder (involuntary muscle spasms in the face and neck): 232 reports
• Eye disorder: 262 reports
• Eye irritation: 112 reports
• Eye pain: 304 reports
• Eye swelling: 173 reports
• Face oedema (swelling of face): 175 reports
• Facet joint syndrome (problem with movement of the facet joints of the spine): 105 reports
• Facial pain: 122 reports
• Faecal incontinence (a lack of control over passing stool): 199 reports
• Faeces discolored: 133 reports
• Failure to thrive (inadequate weight gain and physical growth in children): 101 reports
• Fainting (loss of consciousness and postural tone): 1,138 reports
• Fall: 3,918 reports
• Fatigue (feeling of tiredness): 6,508 reports
• Fear: 491 reports
• Febrile neutropenia (fever with reduced white blood cells): 149 reports
• Feeling cold: 216 reports
• Feeling drunk: 136 reports
• Feeling guilty: 177 reports
• Feeling hot: 487 reports
• Feeling jittery: 362 reports
• Feeling of body temperature change: 114 reports
• Feeling of despair: 152 reports
• Feelings of worthlessness: 151 reports
• Femur fracture: 220 reports
• Fever: 2,215 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 598 reports
• Fibrosis (formation of excess fibrous connective tissue in an organ or tissue): 102 reports
• Fistula (an abnormal connection or passageway between two): 148 reports
• Flank pain (a distressing sensation experienced around the lower back and the upper abdomen): 163 reports
• Flat affect (absence of emotional response to a situation): 120 reports
• Flatulence (flatus expelled through the anus): 481 reports
• Fluid overload (too much fluid in the blood): 106 reports
• Fluid retention (an abnormal accumulation of fluid in the blood): 243 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 173 reports
• Foot deformity (functional disability of foot): 150 reports
• Foot fracture: 299 reports
• Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin): 121 reports
• Fungal infection: 288 reports
• Gait disturbance: 1,659 reports
• Gallbladder disorder: 338 reports
• Gallbladder removal: 124 reports
• Gallstones (stone formation by bile component): 572 reports
• Gamma-glutamyltransferase increased: 230 reports
• Gastric disorder (disease of stomach): 275 reports
• Gastric ulcer (stomach ulcer): 451 reports
• Gastritis (inflammation of stomach): 393 reports
• Gastroenteritis (inflammation of stomach and intestine): 184 reports
• Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection): 143 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1,346 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 455 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 442 reports
• Generalised oedema (swelling all over the body): 103 reports
• Generalized anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry): 156 reports
• General physical health deterioration (weak health status): 960 reports
• Gingival bleeding (bleeding gums): 146 reports
• Gingival disorder (gum disease): 105 reports
• Gingival pain (gum pain): 164 reports
• Gingivitis (inflammation of gums): 176 reports
• Glaucoma (increased fluid pressure in the eye with vision loss): 184 reports
• Glossodynia (a burning or painful sensation in the tongue): 155 reports
• Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 185 reports
• Grand mal convulsion (a type of generalized seizure that affects the entire brain): 373 reports
• Groin pain: 126 reports
• Gums - swollen: 118 reports
• Haematemesis (vomiting of blood): 226 reports
• Haematochezia (passage of stools containing blood): 345 reports
• Haematocrit decreased: 230 reports
• Haematoma (collection of blood outside the blood vessels): 212 reports
• Haematuria (presence of blood in urine): 270 reports
• Haemoglobin decreased: 639 reports
• Haemorrhage (bleeding): 379 reports
• Haemorrhoids (a swollen vein or group of veins in the region of the anus): 402 reports
• Hair color changes: 173 reports
• Hair disorder: 169 reports
• Hair loss: 1,385 reports
• Hallucination, auditory (perceiving sounds without auditory stimulus): 326 reports
• Hallucinations (sensations that appear real but are created by your mind): 934 reports
• Hallucination, visual (seeing things that aren't there): 296 reports
• Hand fracture: 122 reports
• Headache (pain in head): 6,064 reports
• Head discomfort: 150 reports
• Head injury: 1,484 reports
• Hearing impaired: 104 reports
• Hearing loss: 182 reports
• Heart attack: 1,141 reports
• Heart disease: 134 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 1,284 reports
• Heart rate decreased: 253 reports
• Heart rate increased: 1,014 reports
• Heart rate irregular: 285 reports
• Heavy or prolong menstrual bleeding: 221 reports
• Hemiparesis (weakness on one side of the body): 183 reports
• Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 120 reports
• Hepatic cyst: 115 reports
• Hepatic enzyme increased: 389 reports
• Hepatic failure (liver failure): 251 reports
• Hepatic steatosis (fatty liver disease): 354 reports
• Hepatitis (inflammation of the liver): 288 reports
• Hepatomegaly (abnormal enlargement of the liver): 162 reports
• Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 130 reports
• Herniated nucleus pulposus (slipped disk): 160 reports
• Herpes zoster: 465 reports
• Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 375 reports
• High blood cholesterol: 1,451 reports
• High blood pressure: 4,514 reports
• Hip fracture: 191 reports
• Hoarseness or changing voice: 404 reports
• Homicidal ideation (thoughts about human killing another human): 247 reports
• Hospitalisation: 242 reports
• Hostility: 206 reports
• Hot flush (sudden feelings of heat): 1,049 reports
• Hyperacusis (disorder in loudness perception): 103 reports
• Hyperglycemia (high blood sugar): 465 reports
• Hyperhidrosis (abnormally increased sweating): 2,104 reports
• Hyperkalemia (damage to or disease of the kidney): 283 reports
• Hyperkeratosis (thickening of the outer layer of the skin): 117 reports
• Hyperlipidaemia (presence of excess lipids in the blood): 507 reports
• Hypersensitivity: 775 reports
• Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch): 141 reports
• Hypertriglyceridaemia (excess of triglycerides in the blood): 107 reports
• Hyperventilation: 106 reports
• Hypoacusis (loss of hearing): 163 reports
• Hypoaesthesia (reduced sense of touch or sensation): 1,723 reports
• Hypoaesthesia oral (reduced sense of touch or sensation in mouth): 125 reports
• Hypocalcaemia (levels of calcium in blood serum are abnormally low): 178 reports
• Hypoglycemia (low blood sugar): 343 reports
• Hypokalemia (low potassium): 561 reports
• Hypokinesia (decreased bodily movement): 147 reports
• Hypomania (a mild form of mania, marked by elation and hyperactivity): 140 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 780 reports
• Hypophagia (reduced food intake): 310 reports
• Hypotension (abnormally low blood pressure): 1,793 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 484 reports
• Hypovolaemia (a decreased volume of circulating blood in the body): 132 reports
• Idiopathic pulmonary fibrosis (chronic lung disease): 170 reports
• Ill-defined disorder: 249 reports
• Impaired driving ability: 328 reports
• Impaired gastric emptying: 163 reports
• Impaired healing: 501 reports
• Impaired work ability: 478 reports
• Impulsive behavior: 117 reports
• Inappropriate antidiuretic hormone secretion: 116 reports
• Incoherent (talking in a confused and unclear way): 105 reports
• Incontinence (lack of moderation or self-control): 183 reports
• Indigestion: 880 reports
• Infection: 680 reports
• Inflammation: 401 reports
• Influenza like illness: 916 reports
• Infusion related reaction: 197 reports
• Initial insomnia (feeling of inadequate or poor-quality sleep): 114 reports
• Injection site bruising: 181 reports
• Injection site erythema (redness at injection site): 311 reports
• Injection site haemorrhage (bleeding from injection site): 139 reports
• Injection site mass: 124 reports
• Injection site pain: 656 reports
• Injection site pruritus (severe itching at injection site): 160 reports
• Injection site reaction: 176 reports
• Injection site swelling: 148 reports
• Injury: 1,262 reports
• Insomnia (sleeplessness): 4,119 reports
• Intentional overdose: 656 reports
• Intentional self-injury: 308 reports
• International normalised ratio increased: 230 reports
• Interstitial lung disease: 153 reports
• Intervertebral disc degeneration (spinal disc degeneration): 478 reports
• Intervertebral disc disorder (spinal disc disorder): 109 reports
• Intervertebral disc protrusion (spinal disc protrusion): 670 reports
• Intestinal obstruction: 312 reports
• Iron deficiency anaemia: 171 reports
• Irritability: 1,343 reports
• Irritable bowel syndrome: 299 reports
• Itching: 1,682 reports
• Jaundice - yellow skin (a yellowish pigmentation of the skin): 138 reports
• Jaw disorder (jaw disease): 165 reports
• Jaw fracture: 121 reports
• Joint dislocation (a joint position is changed from normal position): 142 reports
• Joint effusion (presence of extra fluid in joint covering): 119 reports
• Joint injury: 239 reports
• Joint pain: 2,829 reports
• Joint stiffness: 211 reports
• Joint swelling: 596 reports
• Kidney infection: 112 reports
• Kidney stones: 494 reports
• Knee joint replacement: 121 reports
• Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back)): 122 reports
• Lacrimation increased: 124 reports
• Laryngitis (inflammation of the larynx): 135 reports
• Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 122 reports
• Leukocytosis (increased white blood cells): 149 reports
• Leukopenia (less number of white blood cells in blood): 232 reports
• Libido decreased (loss of interest in sex): 377 reports
• Ligament sprain (ligament stretched): 147 reports
• Limb discomfort (discomfort in leg): 207 reports
• Limb injury: 226 reports
• Lip swelling: 128 reports
• Liver disorder (liver diseases): 204 reports
• Localised infection (infection at the single location): 153 reports
• Local swelling (swelling at the site of some application of substance or injury): 130 reports
• Loose tooth: 187 reports
• Loss of consciousness: 1,473 reports
• Loss of libido (loss of sexual urge): 155 reports
• Lower limb fracture: 131 reports
• Lower respiratory tract infection: 156 reports
• Low tissue oxygen: 355 reports
• Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 176 reports
• Lung disorder (lung disease): 269 reports
• Lung infection: 136 reports
• Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 196 reports
• Lung neoplasm (tumour of lung): 249 reports
• Lung neoplasm malignant (cancer tumour of lung): 123 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 421 reports
• Lymphocyte count decreased: 155 reports
• Lymphoedema (localized fluid retention and tissue swelling): 119 reports
• Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 399 reports
• Malaise (a feeling of general discomfort or uneasiness): 3,806 reports
• Malignant neoplasm progression (cancer tumour came back): 237 reports
• Malnutrition (condition that results from eating a diet in which certain nutrients are lacking): 188 reports
• Mania (a state of abnormally elevated or irritable mood): 640 reports
• Mastication disorder (disease of chewing food): 126 reports
• Maternal drugs affecting foetus (chemical affecting the baby before birth taken by mother): 274 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 371 reports
• Memory loss: 2,813 reports
• Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia): 104 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 812 reports
• Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 405 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 469 reports
• Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 184 reports
• Metastases to bone (cancer spreads to bone): 375 reports
• Metastases to liver (cancer spreads to liver): 183 reports
• Metastases to lymph nodes (cancer spreads to lymph node): 123 reports
• Metastases to spine (cancer spreads to spine): 131 reports
• Micturition urgency (urgency to pass the urine): 205 reports
• Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night): 220 reports
• Migraine (headache): 1,221 reports
• Mitral valve incompetence (inefficient heart valve): 409 reports
• Mitral valve prolapse (heart's mitral valve doesn't work well): 137 reports
• Mobility decreased (ability to move is reduced): 423 reports
• Mood swings (an extreme or rapid change in mood): 976 reports
• Mouth ulcers: 349 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 338 reports
• Movement - uncontrolled or slow: 222 reports
• Movement - uncoordinated: 187 reports
• Mucosal inflammation (infection of mucous membrane): 168 reports
• Multi-organ failure (multisystem organ failure): 152 reports
• Multiple drug overdose: 131 reports
• Multiple myeloma (cancer of the plasma cells): 222 reports
• Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 415 reports
• Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 452 reports
• Muscle aches (muscle pain): 1,409 reports
• Muscle cramps (painful sensations caused by muscle contraction): 113 reports
• Muscle disorder (muscle disease): 127 reports
• Muscle function loss: 114 reports
• Muscle rigidity (muscle stiffness): 168 reports
• Muscle spasms (muscle contraction): 1,557 reports
• Muscle spasticity (tight or stiff muscles and an inability to control those muscles): 103 reports
• Muscle strain (an injury to a muscle in which the muscle fibres tear): 127 reports
• Muscle tightness: 232 reports
• Muscle twitching: 506 reports
• Musculoskeletal chest pain (pain in chest muscle or nerve or bones): 293 reports
• Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 228 reports
• Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 145 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 644 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 643 reports
• Mydriasis (a dilation of the pupil): 424 reports
• Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 163 reports
• Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 140 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 392 reports
• Nasopharyngitis (inflammation of the nasopharynx): 970 reports
• Nausea (feeling of having an urge to vomit): 7,273 reports
• Nausea and vomiting: 3,479 reports
• Neck pain: 865 reports
• Negative thoughts: 118 reports
• Neoplasm malignant (cancer tumour): 319 reports
• Neoplasm progression (growth of tumour): 116 reports
• Nerve compression: 111 reports
• Nerve injury: 131 reports
• Nervousness: 1,257 reports
• Nervous system disorder (a general class of medical conditions affecting the nervous system): 422 reports
• Neuralgia (pain in one or more nerves): 348 reports
• Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 169 reports
• Neuropathy peripheral (surface nerve damage): 964 reports
• Nightmares (unpleasant dreams): 929 reports
• Night sweats (sweating in night): 574 reports
• Nodule (a small rock or mineral cluster): 126 reports
• Non-accidental overdose: 252 reports
• Nonspecific reaction (unspecified reaction): 124 reports
• Nosebleed (bleeding from nose): 401 reports
• Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 265 reports
• Ocular hyperaemia (an abnormally large amount of blood in eye): 117 reports
• Oedema (fluid collection in tissue): 490 reports
• Oedema peripheral (superficial swelling): 1,545 reports
• Oesophagitis (inflammation of oesophagus): 185 reports
• Oral candidiasis (fungal infection of mouth): 119 reports
• Oral disorder (mouth disease): 151 reports
• Oral herpes (viral infection of mouth): 166 reports
• Oral infection: 119 reports
• Oral pain: 326 reports
• Oropharyngeal pain: 561 reports
• Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 338 reports
• Osteitis (a general term for inflammation of bone): 143 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 966 reports
• Osteolysis (dissolution of bone): 121 reports
• Osteomyelitis (infection of bone): 510 reports
• Osteonecrosis of jaw (death of bone of jaw): 888 reports
• Osteopenia (a condition where bone mineral density is lower than normal): 367 reports
• Osteoporosis (bones weak and more likely to break): 616 reports
• Osteosclerosis (an elevation in bone density): 149 reports
• Otitis (ear infection): 197 reports
• Otitis media (inflammation of the middle ear): 139 reports
• Ovarian cysts (fluid filled sacs of the ovary): 176 reports
• Overdose: 1,758 reports
• Oxygen saturation decreased: 320 reports
• Pain: 5,206 reports
• Pain in extremity: 2,322 reports
• Pain in jaw: 582 reports
• Paleness (unusual lightness of skin colour): 215 reports
• Pancreatitis (inflammation of pancreas): 729 reports
• Pancreatitis acute (sudden inflammation of pancreas): 222 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 355 reports
• Panic disorder: 1,109 reports
• Panic reaction: 170 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 2,704 reports
• Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect): 131 reports
• Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 516 reports
• Parkinson's disease: 326 reports
• Paroxysmal supraventricular tachycardia: 183 reports
• Patent ductus arteriosus (condition in which the ductus arteriosus does not close): 163 reports
• Pathological fracture (broken bone caused by disease): 153 reports
• Pelvic pain: 175 reports
• Pericardial effusion (fluid around the heart): 166 reports
• Periodontal disease (disease that attacks the gum and bone and around the teeth): 117 reports
• Periodontitis (inflammation of the tissue around the teeth): 126 reports
• Peripheral coldness: 124 reports
• Peripheral swelling: 541 reports
• Personality change: 230 reports
• Personality disorder: 146 reports
• Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal): 113 reports
• Pharyngitis (inflammation of the pharynx, causing a sore throat): 193 reports
• Pharyngolaryngeal pain: 141 reports
• Photophobia (extreme sensitivity to light): 209 reports
• Photosensitivity reaction: 161 reports
• Pleural effusion (water on the lungs): 545 reports
• Pneumonia: 1,997 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 215 reports
• Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung): 141 reports
• Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 420 reports
• Poor quality sleep: 287 reports
• Post procedural complication: 162 reports
• Post-traumatic stress disorder: 225 reports
• Pre-existing condition improved: 300 reports
• Premature baby: 337 reports
• Prescribed overdose: 186 reports
• Presyncope: 192 reports
• Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone): 198 reports
• Productive cough: 350 reports
• Pruritus generalised (generalized itching): 141 reports
• Psoriasis (immune-mediated disease that affects the skin): 395 reports
• Psychiatric symptom: 282 reports
• Psychological trauma: 200 reports
• Psychomotor hyperactivity (feelings of extreme restlessness): 265 reports
• Psychotic disorder: 525 reports
• Pulmonary congestion (congestion in the lungs): 137 reports
• Pulmonary embolism (blockage of the main artery of the lung): 1,033 reports
• Pulmonary hypertension (increase in blood pressure in the lung artery): 309 reports
• Pulmonary mass: 134 reports
• Pulmonary oedema (fluid accumulation in the lungs): 388 reports
• Purulent discharge (discharge that contains pus): 158 reports
• Quality of life decreased: 118 reports
• Rash erythematous (redness of the skin): 215 reports
• Rashes (redness): 2,788 reports
• Rash macular (small, flat red spots): 157 reports
• Rash maculo-papular (red area on the skin that is covered with small confluent bumps): 121 reports
• Rash papular (redness with papule): 112 reports
• Rash pruritic (redness with itching): 323 reports
• Rectal haemorrhage (bleeding from anus): 527 reports
• Red blood cell count decreased: 245 reports
• Renal cyst (kidney cyst): 236 reports
• Renal disorder (kidney disease): 220 reports
• Renal failure acute (rapid kidney dysfunction): 598 reports
• Renal failure chronic (long lasting kidney dysfunction): 195 reports
• Renal impairment (severely reduced kidney function): 334 reports
• Renal injury (kidney injury): 142 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 443 reports
• Respiratory disorder (respiratory disease): 187 reports
• Respiratory distress (difficulty in breathing): 301 reports
• Respiratory rate increased (excess breathing rate/min): 125 reports
• Respiratory tract infection: 116 reports
• Restless leg syndrome (a powerful urge to move your legs): 502 reports
• Retching (strong involuntary effort to vomit): 231 reports
• Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 331 reports
• Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 466 reports
• Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 132 reports
• Rib fracture: 464 reports
• Rickets (softening of bones): 151 reports
• Road traffic accident: 738 reports
• Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 281 reports
• Scar: 279 reports
• Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 279 reports
• Scoliosis (a medical condition in which a person's spine is curved from side to side): 202 reports
• Sedation: 888 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 433 reports
• Self esteem decreased (self worth reduced): 109 reports
• Self-injurious ideation: 181 reports
• Sensory disturbance (sense disturbance): 233 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 587 reports
• Septic shock (shock due to blood infection): 184 reports
• Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 606 reports
• Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 154 reports
• Sinus congestion (blockage of sinus): 113 reports
• Sinus disorder (disease of sinus): 184 reports
• Sinus headache (headache caused by sinus infections): 101 reports
• Sinusitis (inflammation of sinus): 1,190 reports
• Sinusitis - chronic: 130 reports
• Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 319 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 684 reports
• Skin - clammy: 193 reports
• Skin discoloration: 325 reports
• Skin discoloration - bluish (bluish colour of skin): 154 reports
• Skin disorder (skin disease): 213 reports
• Skin exfoliation (removal of the oldest dead skin cells): 225 reports
• Skin ulcer: 211 reports
• Sleep apnea syndrome: 662 reports
• Sleep disorder: 847 reports
• Sleep walking (walking during sleep): 228 reports
• Sluggishness (lacking alertness): 119 reports
• Small intestinal obstruction (blockage in small intestine): 101 reports
• Snoring: 122 reports
• Social avoidant behavior: 194 reports
• Speech disorder: 714 reports
• Speech impairment (adult) (inability to speak (adult)): 807 reports
• Spinal column stenosis (narrowing of spinal column): 217 reports
• Spinal compression fracture (fracture due to spinal compression on bone): 106 reports
• Spinal disorder (disease of spine a back bone): 146 reports
• Spinal fracture (fracture in one of vertebrae): 188 reports
• Spinal osteoarthritis (joint cartilage loss in spine): 584 reports
• Splenomegaly (enlargement of spleen): 103 reports
• Stable angina (a constant chest pain): 260 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 385 reports
• Stomatitis (inflammation of mucous membrane of mouth): 333 reports
• Stress and anxiety: 6,812 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1,078 reports
• Subdural haematoma (blood collects between the skull and the surface of the brain): 102 reports
• Suicidal behavior: 131 reports
• Suicidal ideation: 3,432 reports
• Suicide attempt: 1,775 reports
• Surgery: 357 reports
• Swallowing difficulty: 1,006 reports
• Sweating increased (excess sweating): 492 reports
• Swelling: 779 reports
• Swelling face: 415 reports
• Swollen tongue (swelling of tongue): 215 reports
• Synovial cyst (cyst of joint filled with synovial fluid): 132 reports
• Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 171 reports
• Tachypnea: 134 reports
• Tardive dyskinesia (a disorder that involves involuntary movements): 359 reports
• Taste - impaired: 548 reports
• Tearfulness (excess tearing): 190 reports
• Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress): 101 reports
• Tenderness (pain or discomfort when an affected area is touched): 236 reports
• Tendonitis (a condition that causes pain and swelling of tendons): 195 reports
• The flu (the flu is caused by an influenza virus): 709 reports
• Therapeutic response decreased (less preventive response): 230 reports
• Therapeutic response unexpected: 471 reports
• Thirst: 214 reports
• Throat irritation: 186 reports
• Throat tightness: 135 reports
• Thrombocytopenia (decrease of platelets in blood): 894 reports
• Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot): 128 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 448 reports
• Thyroid diseases: 246 reports
• Tinnitus (a ringing in the ears): 859 reports
• Tongue disorder (disease of tongue): 105 reports
• Tooth abscess (pus formation in tooth): 425 reports
• Toothaches (tooth pain): 378 reports
• Tooth disorder (tooth disease): 374 reports
• Tooth extraction: 405 reports
• Tooth fracture: 280 reports
• Tooth loss: 351 reports
• Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 428 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 2,619 reports
• Tricuspid valve incompetence (inefficient heart valve): 382 reports
• Tumor: 184 reports
• Type 1 diabetes: 203 reports
• Type 2 diabetes: 1,166 reports
• Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 179 reports
• Unresponsive to stimuli: 115 reports
• Upper limb fracture: 219 reports
• Upper respiratory tract infection: 566 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 549 reports
• Urinary retention (the inability to completely or partially empty the bladder): 490 reports
• Urinary tract infection: 1,752 reports
• Urination - excessive at night: 125 reports
• Urination - painful: 483 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 840 reports
• Uterine leiomyoma (uterine benign tumour derived from smooth muscle): 134 reports
• Vaginal bleeding: 276 reports
• Vaginal bleeding between periods: 112 reports
• Ventricular extrasystoles (premature cardiac contraction): 169 reports
• Ventricular fibrillation (abnormally irregular heart rhythm): 133 reports
• Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart): 132 reports
• Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital)): 169 reports
• Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 221 reports
• Viral infection: 245 reports
• Vision blurred: 1,298 reports
• Visual acuity reduced (reduced clearness of vision): 278 reports
• Visual disturbance: 283 reports
• Visual impairment: 659 reports
• Vitamin d decreased: 101 reports
• Weakness: 4,317 reports
• Weight decreased: 2,656 reports
• Weight increased: 3,400 reports
• Weight loss: 562 reports
• Wheezing (a high-pitched whistling sound made while you breath): 379 reports
• White blood cell count decreased: 489 reports
• White blood cell count increased: 419 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 1,409 reports
• Wound: 142 reports
• Wound dehiscence (a surgical incision reopens either internally or externally): 117 reports
• Wrist fracture: 155 reports

• Hypertonia (10,473 reports)

• Aspirin: 151 reports
• Avonex: 291 reports
• Baclofen: 564 reports
• Clonazepam: 164 reports
• Copaxone: 137 reports
• Diazepam: 143 reports
• Effexor: 141 reports
• Epivir: 132 reports
• Escitalopram: 131 reports
• Fluoxetine: 123 reports
• Furosemide: 103 reports
• Gabapentin: 121 reports
• Gablofen: 158 reports
• Haldol: 120 reports
• Lamotrigine: 119 reports
• Lioresal: 2,425 reports
• Lorazepam: 168 reports
• Mirtazapine: 127 reports
• Morphine: 104 reports
• Neurontin: 108 reports
• Olanzapine: 110 reports
• Omeprazole: 162 reports
• Paracetamol: 105 reports
• Paroxetine: 180 reports
• Paxil: 119 reports
• Prednisone: 136 reports
• Premarin: 113 reports
• Prozac: 133 reports
• Retrovir: 225 reports
• Risperdal: 192 reports
• Risperidone: 143 reports
• Sertraline: 136 reports
• Synthroid: 104 reports
• Tramadol: 113 reports
• Valium: 138 reports
• Xanax: 124 reports
• Zoloft: 223 reports
• Zyprexa: 119 reports

All the drugs that are associated with Hypertonia:

• Hypertonia (1,253 drugs)

• Bipolar disorder: 106 reports
• Depression: 334 reports
• Epilepsy: 121 reports
• Epilepsy aggravated: 126 reports
• High blood pressure: 131 reports
• Hiv: 116 reports
• Hiv infection: 137 reports
• Hypertension: 126 reports
• Ms: 166 reports
• Multiple sclerosis: 154 reports
• Muscle spasticity: 2,506 reports
• Pain: 178 reports

All the conditions that are associated with Hypertonia:

• Hypertonia (662 conditions)

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