Elmiron and Withdrawal syndrome - a phase IV clinical study of FDA data


Withdrawal syndrome is found among people who take Elmiron, especially for people who are female, 50-59 old.

The phase IV clinical study analyzes which people take Elmiron and have Withdrawal syndrome. It is created by eHealthMe based on reports of 6,637 people who have side effects when taking Elmiron from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 08, 2023

6,637 people reported to have side effects when taking Elmiron.
Among them, 17 people (0.26%) have Withdrawal syndrome.

What is Elmiron?

Elmiron has active ingredients of pentosan polysulfate sodium. It is often used in interstitial cystitis (ic). eHealthMe is studying from 6,921 Elmiron users for its effectiveness, alternative drugs and more.

What is Withdrawal syndrome?

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) is found to be associated with 1,825 drugs and 1,381 conditions by eHealthMe.

Number of Elmiron and Withdrawal syndrome reports submitted per year:

Could Elmiron cause Withdrawal syndrome?

Gender of people who have Withdrawal syndrome when taking Elmiron *:

  • female: 81.25 %
  • male: 18.75 %

Age of people who have Withdrawal syndrome when taking Elmiron *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 7.14 %
  • 30-39: 28.57 %
  • 40-49: 7.14 %
  • 50-59: 57.14 %
  • 60+: 0.0 %

Common drugs people take besides Elmiron *:

  1. Lyrica: 9 people, 52.94%
  2. Ranitidine: 5 people, 29.41%
  3. Valsartan: 5 people, 29.41%
  4. Ultram: 5 people, 29.41%
  5. Premarin: 5 people, 29.41%
  6. Levothroid: 5 people, 29.41%
  7. Meloxicam: 5 people, 29.41%
  8. Dyazide: 4 people, 23.53%
  9. Flexeril: 4 people, 23.53%
  10. Metformin: 3 people, 17.65%

Common side effects people have besides Withdrawal syndrome *:

  1. Suicidal Ideation: 7 people, 41.18%
  2. Depressed Mood: 5 people, 29.41%
  3. Nausea (feeling of having an urge to vomit): 3 people, 17.65%
  4. Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 17.65%
  5. Stress And Anxiety: 2 people, 11.76%
  6. Fatigue (feeling of tiredness): 2 people, 11.76%
  7. Depression: 2 people, 11.76%
  8. Malaise (a feeling of general discomfort or uneasiness): 2 people, 11.76%
  9. Vision Blurred: 2 people, 11.76%
  10. Crying: 1 person, 5.88%

Common conditions people have *:

  1. Pain: 11 people, 64.71%
  2. Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 47.06%
  3. Menopause (end of monthly cycles in women): 6 people, 35.29%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 29.41%
  5. Ankylosing Spondylitis (type of arthritis affecting the spine): 5 people, 29.41%
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 29.41%
  7. High Blood Pressure: 5 people, 29.41%
  8. Hot Flush (sudden feelings of heat): 5 people, 29.41%
  9. Abdominal Discomfort: 5 people, 29.41%
  10. Neuropathy Peripheral (surface nerve damage): 5 people, 29.41%

* Approximation only. Some reports may have incomplete information.

Do you take Elmiron and have Withdrawal syndrome?

Check whether Withdrawal syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Withdrawal syndrome and when was it recovered:

Expand to all the drugs that have ingredients of pentosan polysulfate sodium:

Alternative drugs to, pros and cons of Elmiron:

Common Elmiron side effects:

Browse all side effects of Elmiron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Withdrawal syndrome treatments and more:

COVID vaccines that are related to Withdrawal syndrome:

Common drugs associated with Withdrawal syndrome:

All the drugs that are associated with Withdrawal syndrome:

Common conditions associated with Withdrawal syndrome:

All the conditions that are associated with Withdrawal syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on pentosan polysulfate sodium (the active ingredients of Elmiron) and Elmiron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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