Emla and Wakefulness - a phase IV clinical study of FDA data
Summary:
Wakefulness is found among people who take Emla, especially for people who are female, 60+ old.
The phase IV clinical study analyzes which people take Emla and have Wakefulness. It is created by eHealthMe based on reports of 4,645 people who have side effects when taking Emla from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
4,645 people reported to have side effects when taking Emla.
Among them, 108 people (2.33%) have Wakefulness.
What is Emla?
Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 4,653 Emla users for its effectiveness, alternative drugs and more.
What is Wakefulness?
Wakefulness (not sleeping or not able to sleep) is found to be associated with 4,580 drugs and 5,014 conditions by eHealthMe.
Number of Emla and Wakefulness reports submitted per year:

Gender of people who have Wakefulness when taking Emla*:
Age of people who have Wakefulness when taking Emla *:
Common drugs people take besides Emla *:
Common side effects people have besides Wakefulness *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Emla and have Wakefulness?
Check whether Wakefulness is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Wakefulness and when was it recovered:
Expand to all the drugs that have ingredients of lidocaine; prilocaine:
Alternative drugs to, pros and cons of Emla:
- Emla (4,653 reports)
Common Emla side effects:
- Fatigue (feeling of tiredness): 477 reports
- Diarrhea: 343 reports
- Nausea and vomiting: 297 reports
- Fever: 287 reports
- Headache (pain in head): 283 reports
- Weakness: 281 reports
- Rashes (redness): 247 reports
- Breathing difficulty: 244 reports
Browse all side effects of Emla:
a b c d e f g h i j k l m n o p q r s t u v w x y zWakefulness treatments and more:
- Wakefulness (387,974 reports)
COVID vaccines that are related to Wakefulness:
- Wakefulness in Moderna COVID Vaccine
- Wakefulness in Pfizer BioNTech Covid Vaccine
- Wakefulness in Johnson and Johnson Covid Vaccine
Common drugs associated with Wakefulness:
- Prednisone: 11,837 reports
- Aspirin: 10,926 reports
- Lyrica: 10,535 reports
- Cymbalta: 9,690 reports
- Seroquel: 7,985 reports
- Methotrexate: 7,481 reports
- Humira: 7,415 reports
- Omeprazole: 7,272 reports
- Gabapentin: 7,176 reports
- Synthroid: 7,110 reports
All the drugs that are associated with Wakefulness:
- Wakefulness (4,580 drugs)
Common conditions associated with Wakefulness:
- Depression: 16,686 reports
- Pain: 12,769 reports
- Multiple sclerosis: 12,002 reports
- High blood pressure: 11,095 reports
- Rheumatoid arthritis: 10,870 reports
- Stress and anxiety: 9,545 reports
All the conditions that are associated with Wakefulness:
- Wakefulness (5,014 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on lidocaine; prilocaine (the active ingredients of Emla) and Emla (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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