Epipen and Injection site haematoma - a phase IV clinical study of FDA data

Summary:

Injection site haematoma is found among people who take Epipen, especially for people who are female, 40-49 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Epipen and have Injection site haematoma. It is created by eHealthMe based on reports of 20,390 people who have side effects when taking Epipen from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Nov, 26, 2022

20,390 people reported to have side effects when taking Epipen.
Among them, 84 people (0.41%) have Injection site haematoma.


What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 20,459 Epipen users for its effectiveness, alternative drugs and more.

What is Injection site haematoma?

Injection site haematoma (localized swelling filled with blood at injection site) is found to be associated with 1,124 drugs and 812 conditions by eHealthMe.

Number of Epipen and Injection site haematoma reports submitted per year:

Could Epipen cause Injection site haematoma?

Time on Epipen when people have Injection site haematoma *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Injection site haematoma when taking Epipen *:

  • female: 78.48 %
  • male: 21.52 %

Age of people who have Injection site haematoma when taking Epipen *:

  • 0-1: 4.29 %
  • 2-9: 12.86 %
  • 10-19: 4.29 %
  • 20-29: 14.29 %
  • 30-39: 14.29 %
  • 40-49: 24.29 %
  • 50-59: 12.86 %
  • 60+: 12.86 %

Common drugs people take besides Epipen *:

  1. Folic Acid: 4 people, 4.76%
  2. Zyrtec: 3 people, 3.57%
  3. Aredia: 3 people, 3.57%
  4. Coumadin: 3 people, 3.57%
  5. Valium: 3 people, 3.57%
  6. Forteo: 3 people, 3.57%
  7. Prednisone: 3 people, 3.57%
  8. Prograf: 2 people, 2.38%
  9. Avalide: 2 people, 2.38%
  10. Benadryl: 2 people, 2.38%

Common side effects people have besides Injection site haematoma *:

  1. Accidental Exposure: 50 people, 59.52%
  2. Injection Site Pain: 34 people, 40.48%
  3. Injection Site Swelling: 17 people, 20.24%
  4. Injection Site Pallor (an unhealthy pale appearance at injection site): 12 people, 14.29%
  5. Vasoconstriction (constriction of blood vessels, which increases blood pressure): 11 people, 13.10%
  6. Injection Site Anaesthesia: 7 people, 8.33%
  7. Skeletal Injury (bone and supporting muscle injury): 7 people, 8.33%
  8. Nausea (feeling of having an urge to vomit): 7 people, 8.33%
  9. Injection Site Injury: 7 people, 8.33%
  10. Injection Site Discoloration: 7 people, 8.33%

Common conditions people have *:

  1. Hypersensitivity: 5 people, 5.95%
  2. Asthma: 5 people, 5.95%
  3. Osteoporosis (bones weak and more likely to break): 4 people, 4.76%
  4. High Blood Cholesterol: 4 people, 4.76%
  5. Accidental Exposure: 3 people, 3.57%
  6. Allergy To Arthropod Sting: 3 people, 3.57%
  7. Arthropod Sting (arthropod bite): 3 people, 3.57%
  8. Pain: 3 people, 3.57%
  9. Breathing Difficulty: 2 people, 2.38%
  10. Anaemia (lack of blood): 2 people, 2.38%

* Approximation only. Some reports may have incomplete information.

Do you take Epipen and have Injection site haematoma?

Check whether Injection site haematoma is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related studies

How severe was Injection site haematoma and when was it recovered:

Expand to all the drugs that have ingredients of epinephrine:

Alternative drugs to, pros and cons of Epipen:

Common Epipen side effects:

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Injection site haematoma treatments and more:

COVID vaccines that are related to Injection site haematoma:

Common drugs associated with Injection site haematoma:

All the drugs that are associated with Injection site haematoma:

Common conditions associated with Injection site haematoma:

All the conditions that are associated with Injection site haematoma:

How the study uses the data?

The study uses data from the FDA. It is based on epinephrine (the active ingredients of Epipen) and Epipen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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