Esidrix and Respiratory acidosis - a phase IV clinical study of FDA data


Respiratory acidosis is found among people who take Esidrix, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Esidrix and have Respiratory acidosis. It is created by eHealthMe based on reports of 1,802 people who have side effects when taking Esidrix from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 28, 2023

1,802 people reported to have side effects when taking Esidrix.
Among them, 35 people (1.94%) have Respiratory acidosis.

What is Esidrix?

Esidrix has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 1,816 Esidrix users for its effectiveness, alternative drugs and more.

What is Respiratory acidosis?

Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease) is found to be associated with 3,330 drugs and 3,385 conditions by eHealthMe.

Number of Esidrix and Respiratory acidosis reports submitted per year:

Could Esidrix cause Respiratory acidosis?

Time on Esidrix when people have Respiratory acidosis *:

  • < 1 month: 75 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 25 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Respiratory acidosis when taking Esidrix *:

  • female: 60.61 %
  • male: 39.39 %

Age of people who have Respiratory acidosis when taking Esidrix *:

  • 0-1: 7.41 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 11.11 %
  • 50-59: 25.93 %
  • 60+: 55.56 %

Common drugs people take besides Esidrix *:

  1. Norvasc: 10 people, 28.57%
  2. Lasix: 7 people, 20.00%
  3. Atacand: 7 people, 20.00%
  4. Clopidogrel: 6 people, 17.14%
  5. Novorapid: 5 people, 14.29%
  6. Amlodipine: 4 people, 11.43%
  7. Sporanox: 3 people, 8.57%
  8. Flagyl: 2 people, 5.71%
  9. Blopress: 2 people, 5.71%
  10. Pantoprazole: 2 people, 5.71%

Common side effects people have besides Respiratory acidosis *:

  1. Agitation (state of anxiety or nervous excitement): 8 people, 22.86%
  2. Hypernatraemia (an abnormally high plasma concentration of sodium ions): 7 people, 20.00%
  3. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 7 people, 20.00%
  4. Consciousness - Decreased: 7 people, 20.00%
  5. Blood Creatine Phosphokinase Increased: 6 people, 17.14%
  6. Paresis (condition of muscular weakness): 6 people, 17.14%
  7. Oromandibular Dystonia (affecting the ability to chew, speak and swallow): 5 people, 14.29%
  8. Pneumonia: 5 people, 14.29%
  9. Fever: 5 people, 14.29%
  10. Unresponsive To Stimuli: 5 people, 14.29%

Common conditions people have *:

  1. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 5 people, 14.29%
  2. Lipid Metabolism Disorder (genetic disorders are caused by errors in fatty acid metabolism): 5 people, 14.29%
  3. Constipation: 3 people, 8.57%
  4. High Blood Cholesterol: 2 people, 5.71%
  5. Diarrhea: 2 people, 5.71%
  6. Headache (pain in head): 2 people, 5.71%
  7. Hospitalisation: 2 people, 5.71%
  8. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 5.71%
  9. Cerebral Haemorrhage (bleeding within the brain): 2 people, 5.71%
  10. Muscle Spasms (muscle contraction): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

Do you take Esidrix and have Respiratory acidosis?

Check whether Respiratory acidosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Respiratory acidosis and when was it recovered:

Expand to all the drugs that have ingredients of hydrochlorothiazide:

Alternative drugs to, pros and cons of Esidrix:

Common Esidrix side effects:

Browse all side effects of Esidrix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Respiratory acidosis treatments and more:

COVID vaccines that are related to Respiratory acidosis:

Common drugs associated with Respiratory acidosis:

All the drugs that are associated with Respiratory acidosis:

Common conditions associated with Respiratory acidosis:

All the conditions that are associated with Respiratory acidosis:

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Esidrix) and Esidrix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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