Estazolam and Neuroleptic malignant syndrome - a phase IV clinical study of FDA data

Summary:

Neuroleptic malignant syndrome is found among people who take Estazolam, especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Estazolam and have Neuroleptic malignant syndrome. It is created by eHealthMe based on reports of 2,349 people who have side effects when taking Estazolam from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Oct, 03, 2022

2,349 people reported to have side effects when taking Estazolam.
Among them, 30 people (1.28%) have Neuroleptic malignant syndrome.


What is Estazolam?

Estazolam has active ingredients of estazolam. It is often used in insomnia. eHealthMe is studying from 2,381 Estazolam users for its effectiveness, alternative drugs and more.

What is Neuroleptic malignant syndrome?

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents) is found to be associated with 1,092 drugs and 708 conditions by eHealthMe.

Number of Estazolam and Neuroleptic malignant syndrome reports submitted per year:

Could Estazolam cause Neuroleptic malignant syndrome?

Time on Estazolam when people have Neuroleptic malignant syndrome *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 80 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 20 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Neuroleptic malignant syndrome when taking Estazolam *:

  • female: 44.83 %
  • male: 55.17 %

Age of people who have Neuroleptic malignant syndrome when taking Estazolam *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 20.69 %
  • 40-49: 10.34 %
  • 50-59: 48.28 %
  • 60+: 20.69 %

Common drugs people take besides Estazolam *:

  1. Haloperidol: 6 people, 20.00%
  2. Seroquel: 5 people, 16.67%
  3. Carbamazepine: 5 people, 16.67%
  4. Abilify: 4 people, 13.33%
  5. Artane: 4 people, 13.33%
  6. Risperdal: 3 people, 10.00%
  7. Akineton: 2 people, 6.67%
  8. Zyprexa: 2 people, 6.67%
  9. Triazolam: 2 people, 6.67%
  10. Senna: 1 person, 3.33%

Common side effects people have besides Neuroleptic malignant syndrome *:

  1. Ileus Paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 5 people, 16.67%
  2. Loss Of Consciousness: 4 people, 13.33%
  3. Fever: 3 people, 10.00%
  4. Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 3 people, 10.00%
  5. Cardiac Failure Acute: 3 people, 10.00%
  6. Weight Loss: 2 people, 6.67%
  7. Cardiac Failure: 2 people, 6.67%
  8. Hyperhidrosis (abnormally increased sweating): 2 people, 6.67%
  9. Hyperventilation: 2 people, 6.67%
  10. Flatulence (flatus expelled through the anus): 2 people, 6.67%

Common conditions people have *:

  1. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 20.00%
  2. Depression: 5 people, 16.67%
  3. Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 10.00%
  4. Constipation: 2 people, 6.67%
  5. Parkinson's Disease: 2 people, 6.67%
  6. Delusion (a false belief or opinion): 2 people, 6.67%
  7. Irritability: 2 people, 6.67%
  8. Urinary Tract Infection: 2 people, 6.67%
  9. Urination - Painful: 1 person, 3.33%
  10. Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Estazolam and have Neuroleptic malignant syndrome?

Check whether Neuroleptic malignant syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



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Common conditions associated with Neuroleptic malignant syndrome:

All the conditions that are associated with Neuroleptic malignant syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on estazolam (the active ingredients of Estazolam) and Estazolam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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