Estrace and Atrioventricular block - a phase IV clinical study of FDA data
Summary:
Atrioventricular block is found among people who take Estrace, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years.
The phase IV clinical study analyzes which people take Estrace and have Atrioventricular block. It is created by eHealthMe based on reports of 15,335 people who have side effects when taking Estrace from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
15,335 people reported to have side effects when taking Estrace.
Among them, 9 people (0.06%) have Atrioventricular block.
What is Estrace?
Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 15,740 Estrace users for its effectiveness, alternative drugs and more.
What is Atrioventricular block?
Atrioventricular block (heart block) is found to be associated with 1,564 drugs and 785 conditions by eHealthMe.
Number of Estrace and Atrioventricular block reports submitted per year:

Time on Estrace when people have Atrioventricular block *:
- < 1 month: 0.0 %
- 1 - 6 months: 0.0 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 0.0 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 66.67 %
- 10+ years: 33.33 %
Gender of people who have Atrioventricular block when taking Estrace *:
- female: 100 %
- male: 0.0 %
Age of people who have Atrioventricular block when taking Estrace *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 0.0 %
- 40-49: 11.11 %
- 50-59: 11.11 %
- 60+: 77.78 %
Common drugs people take besides Estrace *:
- Synthroid: 4 people, 44.44%
- Sular: 4 people, 44.44%
- Tenormin: 3 people, 33.33%
- Xalatan: 2 people, 22.22%
- Atenolol: 2 people, 22.22%
- Coumadin: 2 people, 22.22%
- Fosamax: 2 people, 22.22%
- Lovastatin: 2 people, 22.22%
- Lozol: 2 people, 22.22%
- Metoprolol Tartrate: 2 people, 22.22%
Common side effects people have besides Atrioventricular block *:
- Depressed Level Of Consciousness: 4 people, 44.44%
- Hypotension (abnormally low blood pressure): 4 people, 44.44%
- Blood Creatinine Increased: 2 people, 22.22%
- Chest Pain: 2 people, 22.22%
- Vulvovaginal Mycotic Infection (vulvovaginal fungal infection): 2 people, 22.22%
- Head Injury: 2 people, 22.22%
- Cardiac Arrest: 2 people, 22.22%
- Loss Of Consciousness: 2 people, 22.22%
- Anuria (failure of the kidneys to produce urine): 2 people, 22.22%
- Urinary Tract Infection: 2 people, 22.22%
Common conditions people have *:
- Vulvovaginal Pain: 2 people, 22.22%
* Approximation only. Some reports may have incomplete information.
Do you take Estrace and have Atrioventricular block?
Check whether Atrioventricular block is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Atrioventricular block and when was it recovered:
Expand to all the drugs that have ingredients of estradiol:
Alternative drugs to, pros and cons of Estrace:
- Estrace (15,740 reports)
Common Estrace side effects:
- Breast cancer: 1,923 reports
- Fatigue (feeling of tiredness): 941 reports
- Drug ineffective: 937 reports
- Pain: 806 reports
- Headache (pain in head): 720 reports
- Diarrhea: 690 reports
- Joint pain: 622 reports
- High blood pressure: 612 reports
Browse all side effects of Estrace:
a b c d e f g h i j k l m n o p q r s t u v w x y zAtrioventricular block treatments and more:
- Atrioventricular block (8,284 reports)
COVID vaccines that are related to Atrioventricular block:
- Atrioventricular block in Moderna COVID Vaccine
- Atrioventricular block in Pfizer BioNTech Covid Vaccine
- Atrioventricular block in Johnson and Johnson Covid Vaccine
Common drugs associated with Atrioventricular block:
- Aspirin: 635 reports
- Furosemide: 532 reports
- Metformin: 432 reports
- Digoxin: 401 reports
- Lasix: 396 reports
- Lisinopril: 310 reports
- Simvastatin: 306 reports
- Norvasc: 290 reports
- Amlodipine: 289 reports
- Avandia: 285 reports
All the drugs that are associated with Atrioventricular block:
- Atrioventricular block (1,564 drugs)
Common conditions associated with Atrioventricular block:
- High blood pressure: 873 reports
- Diabetes: 395 reports
- Atrial fibrillation/flutter: 379 reports
- High blood cholesterol: 227 reports
- Type 2 diabetes: 208 reports
- Depression: 207 reports
All the conditions that are associated with Atrioventricular block:
- Atrioventricular block (785 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrace) and Estrace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Clarithromycin and Rashes - 4 seconds ago
- Haloperidol and Mental Disorder - 6 seconds ago
- Percocet and End-Tidal Co2 Decreased - 10 seconds ago
- Vitamin B12 and Essential Thrombocythaemia - 10 seconds ago
- Haloperidol and Torsade De Pointes - 12 seconds ago
- Amoxil and Urticaria Chronic - 14 seconds ago
- Haloperidol and Mental Impairment - 15 seconds ago
- Isosorbide Dinitrate and Diabetes - 19 seconds ago
- Haloperidol and Grand Mal Convulsion - 19 seconds ago
- Colcrys and Nightmares - 23 seconds ago