Estrace and Cardiac flutter - a phase IV clinical study of FDA data


Cardiac flutter is found among people who take Estrace, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Estrace and have Cardiac flutter. It is created by eHealthMe based on reports of 14,822 people who have side effects when taking Estrace from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 11, 2022

14,822 people reported to have side effects when taking Estrace.
Among them, 11 people (0.07%) have Cardiac flutter.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 15,216 Estrace users for its effectiveness, alternative drugs and more.

What is Cardiac flutter?

Cardiac flutter (abnormal heart rhythm) is found to be associated with 1,117 drugs and 604 conditions by eHealthMe.

Number of Estrace and Cardiac flutter reports submitted per year:

Could Estrace cause Cardiac flutter?

Gender of people who have Cardiac flutter when taking Estrace *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Cardiac flutter when taking Estrace *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 14.29 %
  • 40-49: 14.29 %
  • 50-59: 14.29 %
  • 60+: 57.14 %

Common drugs people take besides Estrace *:

  1. Nexium: 3 people, 27.27%
  2. Atenolol: 2 people, 18.18%
  3. Chantix: 2 people, 18.18%
  4. Synthroid: 2 people, 18.18%
  5. Zantac: 1 person, 9.09%
  6. Dulera: 1 person, 9.09%
  7. Ginkgo Biloba: 1 person, 9.09%
  8. Fosamax: 1 person, 9.09%
  9. Forteo: 1 person, 9.09%
  10. Excedrin: 1 person, 9.09%

Common side effects people have besides Cardiac flutter *:

  1. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 36.36%
  2. Abdominal Pain Upper: 3 people, 27.27%
  3. Extrasystoles: 3 people, 27.27%
  4. Breathing Difficulty: 3 people, 27.27%
  5. Indigestion: 2 people, 18.18%
  6. Headache (pain in head): 2 people, 18.18%
  7. Nausea (feeling of having an urge to vomit): 2 people, 18.18%
  8. Emotional Disorder: 2 people, 18.18%
  9. Arrhythmias (irregular heartbeat): 2 people, 18.18%
  10. Chest Pain: 2 people, 18.18%

Common conditions people have *:

  1. Urinary Tract Infection: 1 person, 9.09%
  2. Thyroid Diseases: 1 person, 9.09%
  3. Skin Haemorrhage (bleeding into skin): 1 person, 9.09%
  4. Rash Pruritic (redness with itching): 1 person, 9.09%
  5. Osteoporosis (bones weak and more likely to break): 1 person, 9.09%
  6. Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 9.09%
  7. Menstruation Irregular: 1 person, 9.09%
  8. Memory Loss: 1 person, 9.09%
  9. Heart Disease: 1 person, 9.09%
  10. Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Estrace and have Cardiac flutter?

Check whether Cardiac flutter is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Estrace:

Cardiac flutter treatments and more:

COVID vaccines that are related to Cardiac flutter:

How severe was Cardiac flutter and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Common drugs associated with Cardiac flutter:

All the drugs that are associated with Cardiac flutter:

Common conditions associated with Cardiac flutter:

All the conditions that are associated with Cardiac flutter:

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrace) and Estrace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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