Estrace and Eyelid twitch - a phase IV clinical study of FDA data


Eyelid twitch is found among people who take Estrace, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Estrace and have Eyelid twitch. It is created by eHealthMe based on reports of 15,335 people who have side effects when taking Estrace from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 24, 2023

15,335 people reported to have side effects when taking Estrace.
Among them, 8 people (0.05%) have Eyelid twitch.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 15,740 Estrace users for its effectiveness, alternative drugs and more.

What is Eyelid twitch?

Eyelid twitch (spontaneous and uncontrolled spasms of the muscles) is found to be associated with 1,471 drugs and 909 conditions by eHealthMe.

Number of Estrace and Eyelid twitch reports submitted per year:

Could Estrace cause Eyelid twitch?

Gender of people who have Eyelid twitch when taking Estrace *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Eyelid twitch when taking Estrace *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 14.29 %
  • 50-59: 42.86 %
  • 60+: 42.86 %

Common drugs people take besides Estrace *:

  1. Prilosec: 3 people, 37.50%
  2. Botox: 3 people, 37.50%
  3. Zanaflex: 2 people, 25.00%
  4. Amitiza: 2 people, 25.00%
  5. Boniva: 2 people, 25.00%
  6. Gilenya: 2 people, 25.00%
  7. Metoprolol Tartrate: 2 people, 25.00%
  8. Mirapex: 2 people, 25.00%
  9. Nuvigil: 2 people, 25.00%
  10. Percocet: 2 people, 25.00%

Common side effects people have besides Eyelid twitch *:

  1. Headache (pain in head): 4 people, 50.00%
  2. Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 25.00%
  3. General Physical Health Deterioration (weak health status): 2 people, 25.00%
  4. Cough: 2 people, 25.00%
  5. Pachymeningitis (inflammation of the dura mater or outer membrane of the brain): 2 people, 25.00%
  6. Leukopenia (less number of white blood cells in blood): 2 people, 25.00%
  7. Hyperreflexia (overactive or over responsive reflexes): 2 people, 25.00%
  8. Nuclear Magnetic Resonance Imaging Brain Abnormal: 2 people, 25.00%
  9. Neuralgia (pain in one or more nerves): 2 people, 25.00%
  10. Gait Disturbance: 2 people, 25.00%

Common conditions people have *:

  1. Pain: 3 people, 37.50%
  2. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 25.00%
  3. Stress And Anxiety: 1 person, 12.50%
  4. Skin Wrinkling (wrinkle on skin): 1 person, 12.50%
  5. Osteoporosis (bones weak and more likely to break): 1 person, 12.50%
  6. Headache (pain in head): 1 person, 12.50%
  7. Dry Eyes (lack of adequate tears): 1 person, 12.50%
  8. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Estrace and have Eyelid twitch?

Check whether Eyelid twitch is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Eyelid twitch and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Alternative drugs to, pros and cons of Estrace:

Common Estrace side effects:

Browse all side effects of Estrace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Eyelid twitch treatments and more:

COVID vaccines that are related to Eyelid twitch:

Common drugs associated with Eyelid twitch:

All the drugs that are associated with Eyelid twitch:

Common conditions associated with Eyelid twitch:

All the conditions that are associated with Eyelid twitch:

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrace) and Estrace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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