Exforge hct and Osteoporosis - a phase IV clinical study of FDA data

Summary:

We study 3,834 people who have side effects when taking Exforge hct. Osteoporosis is found, especially among people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take Clonazepam and have Multiple allergies.

The phase IV clinical study analyzes which people take Exforge hct and have Osteoporosis. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

What are phase IV trials?

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2023

3,834 people reported to have side effects when taking Exforge hct.
Among them, 21 people (0.55%) have Osteoporosis.

What is Exforge hct?

Exforge hct has active ingredients of amlodipine; hydrochlorothiazide; valsartan. It is used in high blood pressure. Currently, eHealthMe is studying from 3,935 Exforge hct users.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 2,690 drugs and 1,873 conditions by eHealthMe. Currently, we are studying 282,455 people who have Osteoporosis.

Number of Exforge hct and Osteoporosis reports submitted per year:

Time on Exforge hct when people have Osteoporosis *:

Gender of people who have Osteoporosis when taking Exforge hct *:

female: 90 %
male: 10 %

Age of people who have Osteoporosis when taking Exforge hct *:

Common drugs people take besides Exforge hct *:

Common side effects people have besides Osteoporosis *:

Dizziness: 11 people, 52.38%
Stress And Anxiety: 9 people, 42.86%
Cardiac Disorder: 9 people, 42.86%
Depression: 8 people, 38.10%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 7 people, 33.33%
Foot Fracture: 7 people, 33.33%
Rickets (softening of bones): 7 people, 33.33%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 7 people, 33.33%
Migraine (headache): 7 people, 33.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 33.33%

Common conditions people have *:

Multiple Allergies (allergy to multiple agents): 7 people, 33.33%
Diabetes: 5 people, 23.81%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 23.81%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 5 people, 23.81%
Asthma: 3 people, 14.29%
Chest Pain: 3 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 14.29%
Hypertensive Heart Disease: 3 people, 14.29%
Indigestion: 1 person, 4.76%
High Blood Cholesterol: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Exforge hct and have Osteoporosis?

Check whether Osteoporosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .

Related studies

How severe was Osteoporosis and when was it recovered:

Osteoporosis in Exforge hct

Expand to all the drugs that have ingredients of amlodipine; hydrochlorothiazide; valsartan:

Osteoporosis and drugs with ingredients of amlodipine; hydrochlorothiazide; valsartan

Alternative drugs to, pros and cons of Exforge hct:

Exforge hct (3,935 reports)

Browse all side effects of Exforge hct:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Osteoporosis treatments and more:

Osteoporosis (282,455 reports)

Common drugs associated with Osteoporosis:

All the drugs that are associated with Osteoporosis:

Osteoporosis (2,690 drugs)

Common conditions associated with Osteoporosis:

Hiv infection: 14,475 reports
Rheumatoid arthritis: 5,192 reports
High blood pressure: 2,420 reports
Gastroesophageal reflux disease: 2,144 reports
Pain: 2,132 reports

All the conditions that are associated with Osteoporosis:

Osteoporosis (1,873 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine; hydrochlorothiazide; valsartan (the active ingredients of Exforge hct) and Exforge hct (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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