Flonase and Oedema mouth - a phase IV clinical study of FDA data

Summary:

We study 69,507 people who have side effects when taking Flonase. Oedema mouth is found, especially among people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take Xanax and have Asthma.

The phase IV clinical study analyzes which people take Flonase and have Oedema mouth. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 30, 2023

69,507 people reported to have side effects when taking Flonase.
Among them, 28 people (0.04%) have Oedema mouth.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is used in allergies. Currently, eHealthMe is studying from 71,554 Flonase users.

What is Oedema mouth?

Oedema mouth (swelling of mouth) is found to be associated with 1,271 drugs and 748 conditions by eHealthMe. Currently, we are studying 5,060 people who have Oedema mouth.

Number of Flonase and Oedema mouth reports submitted per year:

Time on Flonase when people have Oedema mouth *:

Gender of people who have Oedema mouth when taking Flonase *:

female: 78.57 %
male: 21.43 %

Age of people who have Oedema mouth when taking Flonase *:

Common drugs people take besides Flonase *:

Common side effects people have besides Oedema mouth *:

Fatigue (feeling of tiredness): 12 people, 42.86%
Pain In Jaw: 11 people, 39.29%
Diarrhea: 11 people, 39.29%
Toothaches (tooth pain): 11 people, 39.29%
Periodontal Disease (disease that attacks the gum and bone and around the teeth): 10 people, 35.71%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 10 people, 35.71%
Breast Cancer Recurrent: 10 people, 35.71%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 10 people, 35.71%
Pathological Fracture (broken bone caused by disease): 10 people, 35.71%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 10 people, 35.71%

Common conditions people have *:

Asthma: 10 people, 35.71%
High Blood Pressure: 8 people, 28.57%
Pain: 4 people, 14.29%
Oral Candidiasis (fungal infection of mouth): 4 people, 14.29%
Nervousness: 4 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 14.29%
Muscle Spasms (muscle contraction): 4 people, 14.29%
Insulin-Requiring Type Ii Diabetes Mellitus: 4 people, 14.29%
Ill-Defined Disorder: 4 people, 14.29%
Type 1 Diabetes: 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

Do you take Flonase and have Oedema mouth?

Check whether Oedema mouth is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Lehrer, S., & Rheinstein, P. H. , "Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database", Journal of Alzheimer's disease reports, (Preprint), 1-5., 2018 Jan .

Related studies

Flonase side effects by duration, gender and age:

Flonase side effects (71,554 reports)

Oedema mouth treatments and more:

Oedema mouth (5,060 reports)

Common drugs associated with Oedema mouth:

All the drugs that are associated with Oedema mouth:

Oedema mouth (1,271 drugs)

Common conditions associated with Oedema mouth:

High blood pressure: 374 reports
Osteoporosis: 353 reports
Pain: 171 reports
Rheumatoid arthritis: 161 reports
High blood cholesterol: 158 reports

All the conditions that are associated with Oedema mouth:

Oedema mouth (748 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluticasone propionate (the active ingredients of Flonase) and Flonase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.