Glipizide and Z-e syndrome - a phase IV clinical study of FDA data


We study 61,856 people who have side effects when taking Glipizide. Z-e syndrome is found, especially among people who are male, 60+ old, also take Lotronex.

The phase IV clinical study analyzes which people take Glipizide and have Z-e syndrome. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 03, 2023

61,856 people reported to have side effects when taking Glipizide.
Among them, 2 people (0.0%) have Z-e syndrome.

What is Glipizide?

Glipizide has active ingredients of glipizide. It is used in diabetes. Currently, eHealthMe is studying from 63,007 Glipizide users.

What is Z-e syndrome?

Z-e syndrome (increased production of the hormone gastrin from a small tumour of pancreas) is found to be associated with 145 drugs and 173 conditions by eHealthMe. Currently, we are studying 1,239 people who have Z-e syndrome.

Number of Glipizide and Z-e syndrome reports submitted per year:

Could Glipizide cause Z-e syndrome?

Gender of people who have Z-e syndrome when taking Glipizide *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Z-e syndrome when taking Glipizide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Glipizide *:

  1. Rosiglitazone: 2 people, 100.00%
  2. Lotronex: 2 people, 100.00%

Common side effects people have besides Z-e syndrome *:

  1. Weight Decreased: 2 people, 100.00%
  2. Swallowing Difficulty: 2 people, 100.00%
  3. Diarrhea Aggravated: 2 people, 100.00%
  4. Oesophagitis (inflammation of oesophagus): 1 person, 50.00%
  5. Oesophageal Erosions (wear and tear of oesophagus mucous membrane and tissue): 1 person, 50.00%
  6. Muscle Cramps (painful sensations caused by muscle contraction): 1 person, 50.00%
  7. Markedly Reduced Food Intake: 1 person, 50.00%
  8. Flatulence (flatus expelled through the anus): 1 person, 50.00%
  9. Distress: 1 person, 50.00%

* Approximation only. Some reports may have incomplete information.

Do you take Glipizide and have Z-e syndrome?

Check whether Z-e syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Glipizide side effects by duration, gender and age:

Z-e syndrome treatments and more:

All the drugs that are associated with Z-e syndrome:

All the conditions that are associated with Z-e syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on glipizide (the active ingredients of Glipizide) and Glipizide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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