Glivec and Brain herniation - a phase IV clinical study of FDA data

Summary:

We study 17,769 people who have side effects when taking Glivec. Brain herniation is found, especially among people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take Diclofenac sodium and have Chronic myeloid leukaemia.

The phase IV clinical study analyzes which people take Glivec and have Brain herniation. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 25, 2023

17,769 people reported to have side effects when taking Glivec.
Among them, 8 people (0.05%) have Brain herniation.

What is Glivec?

Glivec has active ingredients of imatinib mesylate. Currently, eHealthMe is studying from 17,777 Glivec users.

What is Brain herniation?

Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull) is found to be associated with 1,365 drugs and 933 conditions by eHealthMe. Currently, we are studying 3,579 people who have Brain herniation.

Number of Glivec and Brain herniation reports submitted per year:

Time on Glivec when people have Brain herniation *:

Gender of people who have Brain herniation when taking Glivec *:

female: 62.5 %
male: 37.5 %

Age of people who have Brain herniation when taking Glivec *:

Common drugs people take besides Glivec *:

Symbicort: 1 person, 12.50%
Pl: 1 person, 12.50%
Methylprednisolone: 1 person, 12.50%
Methotrexate: 1 person, 12.50%
Diclofenac Sodium: 1 person, 12.50%

Common side effects people have besides Brain herniation *:

Subdural Haematoma (blood collects between the skull and the surface of the brain): 3 people, 37.50%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 3 people, 37.50%
Thrombocytopenia (decrease of platelets in blood): 2 people, 25.00%
Anaemia (lack of blood): 2 people, 25.00%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 2 people, 25.00%
Cerebral Haematoma (collection of blood in brain): 2 people, 25.00%
Viith Nerve Paralysis: 1 person, 12.50%
Chest Pain: 1 person, 12.50%
Electrocardiogram St Segment Depression: 1 person, 12.50%
Disturbance In Attention: 1 person, 12.50%

Common conditions people have *:

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 6 people, 75.00%
Thyroid Diseases: 1 person, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 12.50%
Gastrointestinal Stromal Tumor: 1 person, 12.50%
Dizziness: 1 person, 12.50%
Blast Crisis In Myelogenous Leukaemia: 1 person, 12.50%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 12.50%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Glivec and have Brain herniation?

Check whether Brain herniation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

O'rafferty C, McElligott F, Storey L, O'marcaigh A, Smith O, "Pneumatosis intestinalis and imatinib mesylate", Annals of hematology, 2014 Oct .

Related studies

Glivec side effects by duration, gender and age:

Glivec side effects (17,777 reports)

Brain herniation treatments and more:

Brain herniation (3,579 reports)

Common drugs associated with Brain herniation:

All the drugs that are associated with Brain herniation:

Brain herniation (1,365 drugs)

Common conditions associated with Brain herniation:

Atrial fibrillation/flutter: 255 reports
Stroke: 119 reports
High blood pressure: 106 reports

All the conditions that are associated with Brain herniation:

Brain herniation (933 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on imatinib mesylate (the active ingredients of Glivec) and Glivec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.