Glucophage and Nephrotic syndrome - a phase IV clinical study of FDA data


Nephrotic syndrome is found among people who take Glucophage, especially for people who are male, 60+ old.

The phase IV clinical study analyzes which people take Glucophage and have Nephrotic syndrome. It is created by eHealthMe based on reports of 58,116 people who have side effects when taking Glucophage from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

58,116 people reported to have side effects when taking Glucophage.
Among them, 25 people (0.04%) have Nephrotic syndrome.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 59,105 Glucophage users for its effectiveness, alternative drugs and more.

What is Nephrotic syndrome?

Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema) is found to be associated with 1,362 drugs and 973 conditions by eHealthMe.

Number of Glucophage and Nephrotic syndrome reports submitted per year:

Could Glucophage cause Nephrotic syndrome?

Gender of people who have Nephrotic syndrome when taking Glucophage *:

  • female: 45.83 %
  • male: 54.17 %

Age of people who have Nephrotic syndrome when taking Glucophage *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 28.57 %
  • 50-59: 33.33 %
  • 60+: 38.1 %

Common drugs people take besides Glucophage *:

  1. Lasix: 7 people, 28.00%
  2. Amaryl: 5 people, 20.00%
  3. Prilosec: 4 people, 16.00%
  4. Allegra: 4 people, 16.00%
  5. Ambien: 4 people, 16.00%
  6. Zocor: 4 people, 16.00%
  7. Copegus: 3 people, 12.00%
  8. Lipitor: 3 people, 12.00%
  9. Cardizem: 3 people, 12.00%
  10. Neupogen: 3 people, 12.00%

Common side effects people have besides Nephrotic syndrome *:

  1. Cardiac Failure Congestive: 8 people, 32.00%
  2. Weakness: 7 people, 28.00%
  3. Hypotension (abnormally low blood pressure): 6 people, 24.00%
  4. Weight Increased: 5 people, 20.00%
  5. Ascites (accumulation of fluid in the abdominal cavity): 5 people, 20.00%
  6. Cellulitis (infection under the skin): 4 people, 16.00%
  7. Fatigue (feeling of tiredness): 4 people, 16.00%
  8. Hyperkalemia (damage to or disease of the kidney): 4 people, 16.00%
  9. Hepatomegaly (abnormal enlargement of the liver): 4 people, 16.00%
  10. Henoch-Schonlein Purpura (inflammation of the blood vessels in the skin and other body organs): 3 people, 12.00%

Common conditions people have *:

  1. Hepatitis C: 3 people, 12.00%
  2. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 12.00%
  3. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 8.00%
  4. Platelet Aggregation Inhibition: 1 person, 4.00%
  5. Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 4.00%
  6. High Blood Pressure: 1 person, 4.00%
  7. High Blood Cholesterol: 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Glucophage and have Nephrotic syndrome?

Check whether Nephrotic syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Nephrotic syndrome and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Alternative drugs to, pros and cons of Glucophage:

Common Glucophage side effects:

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Nephrotic syndrome treatments and more:

COVID vaccines that are related to Nephrotic syndrome:

Common drugs associated with Nephrotic syndrome:

All the drugs that are associated with Nephrotic syndrome:

Common conditions associated with Nephrotic syndrome:

All the conditions that are associated with Nephrotic syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Glucophage) and Glucophage (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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