Humira and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Humira, especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Humira and have Dupuytren's contracture. It is created by eHealthMe based on reports of 606,284 people who have side effects when taking Humira from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On May, 12, 2022

606,284 people reported to have side effects when taking Humira.
Among them, 63 people (0.01%) have Dupuytren's contracture.

What is Humira?

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 608,965 Humira users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 443 drugs and 204 conditions by eHealthMe.

Number of Humira and Dupuytren's contracture reports submitted per year:

Could Humira cause Dupuytren's contracture?

Time on Humira when people have Dupuytren's contracture *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 5.26 %
  • 6 - 12 months: 15.79 %
  • 1 - 2 years: 21.05 %
  • 2 - 5 years: 42.11 %
  • 5 - 10 years: 15.79 %
  • 10+ years: 0.0 %

Gender of people who have Dupuytren's contracture when taking Humira *:

  • female: 42.86 %
  • male: 57.14 %

Age of people who have Dupuytren's contracture when taking Humira *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 12.5 %
  • 50-59: 34.38 %
  • 60+: 53.12 %

Common drugs people take besides Humira *:

  1. Enbrel: 7 people, 11.11%
  2. Synthroid: 6 people, 9.52%
  3. Methotrexate: 5 people, 7.94%
  4. Vitamin D3: 5 people, 7.94%
  5. Zyrtec: 4 people, 6.35%
  6. Vitamin D: 4 people, 6.35%
  7. Amlodipine: 4 people, 6.35%
  8. Percocet: 4 people, 6.35%
  9. Zantac: 4 people, 6.35%
  10. Xeljanz: 3 people, 4.76%

Common side effects people have besides Dupuytren's contracture *:

  1. Joint Pain: 13 people, 20.63%
  2. Drug Ineffective: 9 people, 14.29%
  3. Depression: 6 people, 9.52%
  4. Hypoaesthesia (reduced sense of touch or sensation): 6 people, 9.52%
  5. Joint Stiffness: 5 people, 7.94%
  6. Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 5 people, 7.94%
  7. Nasopharyngitis (inflammation of the nasopharynx): 5 people, 7.94%
  8. Post Procedural Complication: 5 people, 7.94%
  9. High Blood Pressure: 5 people, 7.94%
  10. Pain In Extremity: 5 people, 7.94%

Common conditions people have *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 16 people, 25.40%
  2. Psoriasis (immune-mediated disease that affects the skin): 14 people, 22.22%
  3. High Blood Pressure: 10 people, 15.87%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.35%
  5. Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 4.76%
  6. Pain: 3 people, 4.76%
  7. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 4.76%
  8. Diabetes: 3 people, 4.76%
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 4.76%
  10. Hypersensitivity: 3 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Humira and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Humira:

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of adalimumab:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on adalimumab (the active ingredients of Humira) and Humira (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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