Humira and Heart valve calcification - a phase IV clinical study of FDA data

Summary:

Heart valve calcification is found among people who take Humira, especially for people who are male, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Humira and have Heart valve calcification. It is created by eHealthMe based on reports of 647,817 people who have side effects when taking Humira from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Nov, 28, 2022

647,817 people reported to have side effects when taking Humira.
Among them, 16 people (0.0%) have Heart valve calcification.


What is Humira?

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 650,575 Humira users for its effectiveness, alternative drugs and more.

What is Heart valve calcification?

Heart valve calcification (deposits of calcium (calcification) in parts of the valve) is found to be associated with 212 drugs and 102 conditions by eHealthMe.

Number of Humira and Heart valve calcification reports submitted per year:

Could Humira cause Heart valve calcification?

Time on Humira when people have Heart valve calcification *:

  • < 1 month: 37.5 %
  • 1 - 6 months: 12.5 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 25.0 %
  • 5 - 10 years: 12.5 %
  • 10+ years: 12.5 %

Gender of people who have Heart valve calcification when taking Humira *:

  • female: 37.5 %
  • male: 62.5 %

Age of people who have Heart valve calcification when taking Humira *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 25 %
  • 60+: 75 %

Common drugs people take besides Humira *:

  1. Nexium: 2 people, 12.50%
  2. Bee Pollen: 2 people, 12.50%
  3. Hydrochlorothiazide: 2 people, 12.50%
  4. Voltaren: 1 person, 6.25%
  5. Imdur: 1 person, 6.25%
  6. Ambien: 1 person, 6.25%
  7. Ativan: 1 person, 6.25%
  8. Azathioprine: 1 person, 6.25%
  9. Azathioprine Sodium: 1 person, 6.25%
  10. Baby Aspirin: 1 person, 6.25%

Common side effects people have besides Heart valve calcification *:

  1. Unresponsive To Stimuli: 4 people, 25.00%
  2. Fall: 3 people, 18.75%
  3. Hypotension (abnormally low blood pressure): 2 people, 12.50%
  4. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 12.50%
  5. Bacteraemia (presence of bacteria in the blood): 2 people, 12.50%
  6. Blindness: 2 people, 12.50%
  7. Breathing - Slowed Or Stopped: 2 people, 12.50%
  8. Breathing Difficulty: 2 people, 12.50%
  9. Cardiac Murmur (an heart sound in valve abnormality): 2 people, 12.50%
  10. Chest Pain: 2 people, 12.50%

Common conditions people have *:

  1. Psoriasis (immune-mediated disease that affects the skin): 4 people, 25.00%
  2. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 18.75%
  3. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 18.75%
  4. High Blood Pressure: 3 people, 18.75%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 18.75%
  6. Migraine (headache): 1 person, 6.25%
  7. Cardiac Disorder: 1 person, 6.25%
  8. Cataract (clouding of the lens inside the eye): 1 person, 6.25%
  9. Depression: 1 person, 6.25%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Humira and have Heart valve calcification?

Check whether Heart valve calcification is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related publications that referenced our studies

Related studies

How severe was Heart valve calcification and when was it recovered:

Expand to all the drugs that have ingredients of adalimumab:

Alternative drugs to, pros and cons of Humira:

Common Humira side effects:

Browse all side effects of Humira:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Heart valve calcification treatments and more:

COVID vaccines that are related to Heart valve calcification:

All the drugs that are associated with Heart valve calcification:

All the conditions that are associated with Heart valve calcification:

How the study uses the data?

The study uses data from the FDA. It is based on adalimumab (the active ingredients of Humira) and Humira (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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