Humira and Macrocytosis - a phase IV clinical study of FDA data


Macrocytosis is found among people who take Humira, especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Humira and have Macrocytosis. It is created by eHealthMe based on reports of 647,817 people who have side effects when taking Humira from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 06, 2023

647,817 people reported to have side effects when taking Humira.
Among them, 53 people (0.01%) have Macrocytosis.

What is Humira?

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 650,617 Humira users for its effectiveness, alternative drugs and more.

What is Macrocytosis?

Macrocytosis (enlargement of red blood cells with near-constant haemoglobin concentration) is found to be associated with 996 drugs and 537 conditions by eHealthMe.

Number of Humira and Macrocytosis reports submitted per year:

Could Humira cause Macrocytosis?

Time on Humira when people have Macrocytosis *:

  • < 1 month: 18.75 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 18.75 %
  • 1 - 2 years: 6.25 %
  • 2 - 5 years: 31.25 %
  • 5 - 10 years: 18.75 %
  • 10+ years: 6.25 %

Gender of people who have Macrocytosis when taking Humira *:

  • female: 66 %
  • male: 34 %

Age of people who have Macrocytosis when taking Humira *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 20.0 %
  • 40-49: 3.33 %
  • 50-59: 46.67 %
  • 60+: 30.0 %

Common drugs people take besides Humira *:

  1. Calcium: 10 people, 18.87%
  2. Plaquenil: 9 people, 16.98%
  3. Methotrexate: 9 people, 16.98%
  4. Cimzia: 8 people, 15.09%
  5. Valtrex: 7 people, 13.21%
  6. Arava: 7 people, 13.21%
  7. Folic Acid: 7 people, 13.21%
  8. Pantoprazole: 6 people, 11.32%
  9. Enbrel: 5 people, 9.43%
  10. Cozaar: 4 people, 7.55%

Common side effects people have besides Macrocytosis *:

  1. Joint Pain: 14 people, 26.42%
  2. Nausea (feeling of having an urge to vomit): 11 people, 20.75%
  3. Neck Pain: 10 people, 18.87%
  4. Diarrhea: 10 people, 18.87%
  5. Abdominal Pain Upper: 10 people, 18.87%
  6. Nausea And Vomiting: 10 people, 18.87%
  7. Drug Ineffective: 8 people, 15.09%
  8. Hair Loss: 8 people, 15.09%
  9. Hypoaesthesia (reduced sense of touch or sensation): 8 people, 15.09%
  10. Haematocrit Decreased: 8 people, 15.09%

Common conditions people have *:

  1. Pain: 8 people, 15.09%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 7.55%
  3. Psoriasis (immune-mediated disease that affects the skin): 4 people, 7.55%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.66%
  5. High Blood Cholesterol: 3 people, 5.66%
  6. Appendicitis Perforated (perforated appendicitis is a condition in which an inflamed appendix bursts): 3 people, 5.66%
  7. Colitis (inflammation of colon): 2 people, 3.77%
  8. Depression: 2 people, 3.77%
  9. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 3.77%
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 3.77%

* Approximation only. Some reports may have incomplete information.

Do you take Humira and have Macrocytosis?

Check whether Macrocytosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Macrocytosis and when was it recovered:

Expand to all the drugs that have ingredients of adalimumab:

Alternative drugs to, pros and cons of Humira:

Common Humira side effects:

Browse all side effects of Humira:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Macrocytosis treatments and more:

COVID vaccines that are related to Macrocytosis:

Common drugs associated with Macrocytosis:

All the drugs that are associated with Macrocytosis:

Common conditions associated with Macrocytosis:

All the conditions that are associated with Macrocytosis:

How the study uses the data?

The study uses data from the FDA. It is based on adalimumab (the active ingredients of Humira) and Humira (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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