Humira and Microcytic anaemia - a phase IV clinical study of FDA data


We study 735,454 people who have side effects when taking Humira. Microcytic anaemia is found, especially among people who are male, 60+ old, have been taking the drug for 1 - 6 months, also take Fish oil and have Pain.

The phase IV clinical study analyzes which people take Humira and have Microcytic anaemia. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2023

735,454 people reported to have side effects when taking Humira.
Among them, 77 people (0.01%) have Microcytic anaemia.

What is Humira?

Humira has active ingredients of adalimumab. It is used in rheumatoid arthritis. Currently, eHealthMe is studying from 738,352 Humira users.

What is Microcytic anaemia?

Microcytic anaemia (a generic term for any type of anaemia characterized by small red blood cells) is found to be associated with 1,004 drugs and 480 conditions by eHealthMe. Currently, we are studying 3,008 people who have Microcytic anaemia.

Number of Humira and Microcytic anaemia reports submitted per year:

Could Humira cause Microcytic anaemia?

Time on Humira when people have Microcytic anaemia *:

  • < 1 month: 22.22 %
  • 1 - 6 months: 29.63 %
  • 6 - 12 months: 22.22 %
  • 1 - 2 years: 18.52 %
  • 2 - 5 years: 7.41 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Microcytic anaemia when taking Humira *:

  • female: 46.75 %
  • male: 53.25 %

Age of people who have Microcytic anaemia when taking Humira *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 22.39 %
  • 20-29: 7.46 %
  • 30-39: 11.94 %
  • 40-49: 11.94 %
  • 50-59: 16.42 %
  • 60+: 29.85 %

Common drugs people take besides Humira *:

  1. Fish Oil: 11 people, 14.29%
  2. Flonase: 10 people, 12.99%
  3. Tamsulosin: 10 people, 12.99%
  4. Hydrocodone: 10 people, 12.99%
  5. Lyrica: 10 people, 12.99%
  6. Amlodipine: 10 people, 12.99%
  7. Vitamin D3: 9 people, 11.69%
  8. Ativan: 9 people, 11.69%
  9. Methotrexate: 7 people, 9.09%
  10. Prednisone: 7 people, 9.09%

Common side effects people have besides Microcytic anaemia *:

  1. Fever: 17 people, 22.08%
  2. Diarrhea: 16 people, 20.78%
  3. Abdominal Pain: 15 people, 19.48%
  4. Iron Deficiency: 15 people, 19.48%
  5. Fatigue (feeling of tiredness): 14 people, 18.18%
  6. C-Reactive Protein Increased: 13 people, 16.88%
  7. Weakness: 13 people, 16.88%
  8. Joint Pain: 13 people, 16.88%
  9. Pain: 13 people, 16.88%
  10. Enlarged Prostate: 13 people, 16.88%

Common conditions people have *:

  1. Pain: 15 people, 19.48%
  2. Arthritis (form of joint disorder that involves inflammation of one or more joints): 13 people, 16.88%
  3. Ankylosing Spondylitis (type of arthritis affecting the spine): 12 people, 15.58%
  4. High Blood Pressure: 11 people, 14.29%
  5. Inflammation: 10 people, 12.99%
  6. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 10 people, 12.99%
  7. Neuralgia (pain in one or more nerves): 10 people, 12.99%
  8. Glaucoma (increased fluid pressure in the eye with vision loss): 10 people, 12.99%
  9. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 12.99%
  10. Constipation: 10 people, 12.99%

* Approximation only. Some reports may have incomplete information.

Do you take Humira and have Microcytic anaemia?

Check whether Microcytic anaemia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Humira side effects by duration, gender and age:

Microcytic anaemia treatments and more:

Common drugs associated with Microcytic anaemia:

All the drugs that are associated with Microcytic anaemia:

Common conditions associated with Microcytic anaemia:

All the conditions that are associated with Microcytic anaemia:

How the study uses the data?

The study uses data from the FDA. It is based on adalimumab (the active ingredients of Humira) and Humira (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: