Humulin r and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is reported only by a few people who take Humulin R.

The phase IV clinical study analyzes which people take Humulin r and have Dupuytren's contracture. It is created by eHealthMe based on reports of 20,849 people who have side effects while taking Humulin r from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 17, 2022

20,849 people reported to have side effects when taking Humulin r.
Among them, 2 people (0.01%) have Dupuytren's contracture.

What is Humulin r?

Humulin r has active ingredients of insulin recombinant human. It is often used in type 1 diabetes. eHealthMe is studying from 19,918 Humulin r users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 445 drugs and 208 conditions by eHealthMe.

Number of Humulin r and Dupuytren's contracture reports submitted per year:

Could Humulin r cause Dupuytren's contracture?

Time on Humulin r when people have Dupuytren's contracture *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Dupuytren's contracture when taking Humulin r *:

  • female: 50 %
  • male: 50 %

Age of people who have Dupuytren's contracture when taking Humulin r *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 50 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 50 %

Common drugs people take besides Humulin r *:

  1. Tamiflu: 1 person, 50.00%
  2. Paracetamol: 1 person, 50.00%
  3. Pantethine: 1 person, 50.00%
  4. Nesina: 1 person, 50.00%
  5. Levemir: 1 person, 50.00%
  6. Lantus: 1 person, 50.00%
  7. Humulin N: 1 person, 50.00%
  8. Humalog: 1 person, 50.00%
  9. Heparin: 1 person, 50.00%
  10. Aricept: 1 person, 50.00%

Common side effects people have besides Dupuytren's contracture *:

  1. Vulvar Erosion (breaks down of vulvar skin): 1 person, 50.00%
  2. Visual Field Defect: 1 person, 50.00%
  3. Itching: 1 person, 50.00%
  4. Hepatic Function Abnormal: 1 person, 50.00%
  5. Haemorrhoidal Haemorrhage (bleeding from the haemorrhoids): 1 person, 50.00%
  6. General Physical Health Deterioration (weak health status): 1 person, 50.00%
  7. Fever: 1 person, 50.00%
  8. Face Oedema (swelling of face): 1 person, 50.00%
  9. Eyelid Oedema (eyelids are swollen and contain excessive fluid): 1 person, 50.00%
  10. Eye Haemorrhage (bleeding in the eye): 1 person, 50.00%

Common conditions people have *:

  1. Stable Angina (a constant chest pain): 1 person, 50.00%
  2. Skin Ulcer: 1 person, 50.00%
  3. Constipation: 1 person, 50.00%
  4. Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 1 person, 50.00%
  5. Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 1 person, 50.00%
  6. Eye Inflammation: 1 person, 50.00%
  7. Fever: 1 person, 50.00%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 50.00%
  9. Haemorrhoids (a swollen vein or group of veins in the region of the anus): 1 person, 50.00%
  10. High Blood Cholesterol: 1 person, 50.00%

* Approximation only. Some reports may have incomplete information.

Do you take Humulin r and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of insulin recombinant human:

Alternative drugs to, pros and cons of Humulin r:

Common Humulin r side effects:

Browse all side effects of Humulin r:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

Common conditions associated with Dupuytren's contracture:

  • Ra: 104 reports

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on insulin recombinant human (the active ingredients of Humulin r) and Humulin r (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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