Hydramine and Restless leg syndrome - a phase IV clinical study of FDA data
Summary:
Restless leg syndrome is found among people who take Hydramine, especially for people who are female, 60+ old, have been taking the drug for < 1 month.
The phase IV clinical study analyzes which people take Hydramine and have Restless leg syndrome. It is created by eHealthMe based on reports of 85,683 people who have side effects when taking Hydramine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
85,683 people reported to have side effects when taking Hydramine.
Among them, 206 people (0.24%) have Restless leg syndrome.
What is Hydramine?
Hydramine has active ingredients of diphenhydramine hydrochloride. eHealthMe is studying from 72,101 Hydramine users for its effectiveness, alternative drugs and more.
What is Restless leg syndrome?
Restless leg syndrome (a powerful urge to move your legs) is found to be associated with 2,312 drugs and 1,739 conditions by eHealthMe.
Number of Hydramine and Restless leg syndrome reports submitted per year:

Time on Hydramine when people have Restless leg syndrome *:
Gender of people who have Restless leg syndrome when taking Hydramine*:
Age of people who have Restless leg syndrome when taking Hydramine *:
Common drugs people take besides Hydramine *:
Common side effects people have besides Restless leg syndrome *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Hydramine and have Restless leg syndrome?
Check whether Restless leg syndrome is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Restless leg syndrome and when was it recovered:
Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:
Alternative drugs to, pros and cons of Hydramine:
- Hydramine (72,101 reports)
Common Hydramine side effects:
- Abdominal discomfort: 680 reports
- Abdominal distension: 580 reports
- Abdominal pain: 1,623 reports
- Abdominal pain upper: 1,025 reports
- Abnormal behavior: 138 reports
- Accidental overdose (therapeutic agent): 237 reports
- Acne (skin problems that cause pimples): 241 reports
- Acute kidney failure: 706 reports
- Adverse event: 106 reports
- Aggression: 159 reports
- Agitation (state of anxiety or nervous excitement): 745 reports
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 837 reports
- Alanine aminotransferase increased: 486 reports
- Anaemia (lack of blood): 1,385 reports
- Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 600 reports
- Anger: 128 reports
- Angioedema (rapid swelling of the dermis): 221 reports
- Anhedonia (inability to experience pleasure from activities usually found enjoyable): 167 reports
- Ankle fracture: 122 reports
- Anticholinergic syndrome (absolute or relative reduction in cholinergic activity in the central nervous system): 107 reports
- Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 1,034 reports
- Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 163 reports
- Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system): 201 reports
- Arrhythmias (irregular heartbeat): 1,191 reports
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 1,024 reports
- Arthropathy: 672 reports
- Ascites (accumulation of fluid in the abdominal cavity): 190 reports
- Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 151 reports
- Aspartate aminotransferase increased: 370 reports
- Asthma: 878 reports
- Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 661 reports
- Back pain: 2,146 reports
- Bacteraemia (presence of bacteria in the blood): 112 reports
- Bacterial infection: 190 reports
- Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills): 126 reports
- Bleeding disorders: 103 reports
- Blood alkaline phosphatase increased: 145 reports
- Blood bilirubin increased: 234 reports
- Blood creatinine increased: 429 reports
- Blood glucose decreased: 131 reports
- Blood glucose increased: 619 reports
- Blood lactate dehydrogenase increased: 113 reports
- Blood magnesium decreased: 118 reports
- Blood potassium decreased: 270 reports
- Blood pressure diastolic increased: 391 reports
- Blood pressure fluctuation: 2,997 reports
- Blood pressure management: 185 reports
- Blood pressure systolic increased: 1,536 reports
- Blood urea increased: 171 reports
- Body temperature increased: 513 reports
- Bone density decreased: 132 reports
- Bone disorder: 185 reports
- Bone pain: 361 reports
- Bradycardia (abnormally slow heart action): 371 reports
- Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 163 reports
- Breathing difficulty: 3,605 reports
- Breathing - slowed or stopped: 644 reports
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1,632 reports
- Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 561 reports
- Canker sores (painful, open sore in the mouth): 174 reports
- Cardiac arrest: 1,105 reports
- Cardiac disorder: 408 reports
- Cardiac failure congestive: 325 reports
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 867 reports
- Celiac disease - sprue (a disease of the small intestine): 320 reports
- Cellulitis (infection under the skin): 701 reports
- Chest pain: 2,392 reports
- Chills (felling of cold): 1,463 reports
- Chronic kidney disease: 487 reports
- Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection): 102 reports
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 277 reports
- Colitis (inflammation of colon): 293 reports
- Completed suicide (act of taking one's own life): 3,493 reports
- Confusional state: 751 reports
- Conjunctivitis (pink eye): 196 reports
- Consciousness - decreased: 350 reports
- Constipation: 1,410 reports
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 214 reports
- Cough: 3,070 reports
- Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 215 reports
- Crying: 110 reports
- Cyst (a closed sac): 108 reports
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 188 reports
- Death: 2,463 reports
- Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 308 reports
- Dehydration (dryness resulting from the removal of water): 954 reports
- Delirium (wild excitement): 309 reports
- Depressed level of consciousness: 264 reports
- Depression: 1,110 reports
- Diabetes: 427 reports
- Diarrhea: 3,078 reports
- Disease progression: 354 reports
- Disseminated intravascular coagulation (systemic activation of blood coagulation): 116 reports
- Dizziness: 2,687 reports
- Drowsiness: 2,241 reports
- Drug abuse and dependence: 2,708 reports
- Drug effect decreased: 227 reports
- Drug hypersensitivity: 1,522 reports
- Drug ineffective: 4,367 reports
- Drug toxicity: 400 reports
- Dry eyes (lack of adequate tears): 262 reports
- Dry mouth: 588 reports
- Dry skin: 279 reports
- Dyskinesia (abnormality or impairment of voluntary movement): 112 reports
- Dyspnea exertional: 385 reports
- Ear pain: 349 reports
- Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear): 148 reports
- Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 171 reports
- Electrocardiogram qt prolonged: 381 reports
- Emotional distress: 309 reports
- Eye infection: 202 reports
- Eye pain: 232 reports
- Face oedema (swelling of face): 118 reports
- Facial paralysis (loss of function of face muscle): 102 reports
- Fainting (loss of consciousness and postural tone): 559 reports
- Fall: 1,806 reports
- Fatigue (feeling of tiredness): 6,255 reports
- Febrile neutropenia (fever with reduced white blood cells): 1,000 reports
- Feeling hot: 550 reports
- Femur fracture: 164 reports
- Fever: 3,624 reports
- Fibromyalgia (a long-term condition which causes pain all over the body): 397 reports
- Fluid retention (an abnormal accumulation of fluid in the blood): 488 reports
- Food allergy: 360 reports
- Foot deformity (functional disability of foot): 206 reports
- Fungal infection: 449 reports
- Gait disturbance: 855 reports
- Gallstones (stone formation by bile component): 222 reports
- Gastric ulcer (stomach ulcer): 374 reports
- Gastritis (inflammation of stomach): 196 reports
- Gastroenteritis (inflammation of stomach and intestine): 167 reports
- Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection): 269 reports
- Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 531 reports
- General physical health deterioration (weak health status): 286 reports
- Glaucoma (increased fluid pressure in the eye with vision loss): 136 reports
- Haematemesis (vomiting of blood): 119 reports
- Haematochezia (passage of stools containing blood): 378 reports
- Haematocrit decreased: 376 reports
- Haematoma (collection of blood outside the blood vessels): 137 reports
- Haematuria (presence of blood in urine): 161 reports
- Haemoglobin decreased: 942 reports
- Hair loss: 891 reports
- Hallucinations (sensations that appear real but are created by your mind): 327 reports
- Headache (pain in head): 5,635 reports
- Head injury: 1,034 reports
- Hearing loss: 126 reports
- Heart attack: 466 reports
- Heart palpitations (feelings or sensations that your heart is pounding or racing): 970 reports
- Heart rate decreased: 1,739 reports
- Heart rate increased: 1,910 reports
- Heart rate irregular: 990 reports
- Hepatic enzyme increased: 724 reports
- Hepatic failure (liver failure): 139 reports
- Hepatotoxicity (chemical-driven liver damage): 145 reports
- Hereditary angioedema (recurrent episodes of severe swelling): 348 reports
- Herpes zoster: 1,096 reports
- Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 143 reports
- High blood cholesterol: 608 reports
- High blood pressure: 5,695 reports
- Hip fracture: 147 reports
- Hoarseness or changing voice: 351 reports
- Hyperglycemia (high blood sugar): 227 reports
- Hyperhidrosis (abnormally increased sweating): 1,402 reports
- Hypersensitivity: 1,590 reports
- Hypoaesthesia (reduced sense of touch or sensation): 1,326 reports
- Hypoglycemia (low blood sugar): 228 reports
- Hypokalemia (low potassium): 320 reports
- Hypotension (abnormally low blood pressure): 3,191 reports
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 223 reports
- Idiopathic pulmonary fibrosis (chronic lung disease): 188 reports
- Ill-defined disorder: 567 reports
- Immunodeficiency: 389 reports
- Impaired healing: 368 reports
- Indigestion: 485 reports
- Infection: 1,548 reports
- Inflammation: 511 reports
- Influenza like illness: 799 reports
- Infusion related reaction: 5,015 reports
- Injury: 269 reports
- Insomnia (sleeplessness): 1,391 reports
- Intentional overdose: 354 reports
- Interstitial lung disease: 224 reports
- Intervertebral disc degeneration (spinal disc degeneration): 143 reports
- Intervertebral disc protrusion (spinal disc protrusion): 246 reports
- Intestinal obstruction: 276 reports
- Irritability: 256 reports
- Irritable bowel syndrome: 109 reports
- Itching: 2,530 reports
- Joint injury: 254 reports
- Joint pain: 4,721 reports
- Joint swelling: 1,941 reports
- Kidney stones: 428 reports
- Lacrimation increased: 238 reports
- Leukopenia (less number of white blood cells in blood): 416 reports
- Ligament sprain (ligament stretched): 167 reports
- Localised infection (infection at the single location): 522 reports
- Loss of consciousness: 716 reports
- Lower respiratory tract infection: 660 reports
- Lung disorder (lung disease): 408 reports
- Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 108 reports
- Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 289 reports
- Malaise (a feeling of general discomfort or uneasiness): 2,795 reports
- Malignant neoplasm progression (cancer tumour came back): 239 reports
- Maternal exposure during pregnancy (use of substance during pregnancy): 306 reports
- Memory loss: 549 reports
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 380 reports
- Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 206 reports
- Migraine (headache): 964 reports
- Mobility decreased (ability to move is reduced): 374 reports
- Monocyte count increased: 143 reports
- Mood swings (an extreme or rapid change in mood): 148 reports
- Mouth ulcers: 216 reports
- Movement - uncontrolled or slow: 102 reports
- Movement - uncoordinated: 118 reports
- Multi-organ failure (multisystem organ failure): 132 reports
- Multiple drug overdose: 187 reports
- Multiple myeloma (cancer of the plasma cells): 127 reports
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 190 reports
- Muscle aches (muscle pain): 796 reports
- Muscle spasms (muscle contraction): 860 reports
- Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 144 reports
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 548 reports
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1,168 reports
- Mydriasis (a dilation of the pupil): 217 reports
- Nasopharyngitis (inflammation of the nasopharynx): 3,198 reports
- Nausea (feeling of having an urge to vomit): 5,088 reports
- Nausea and vomiting: 2,743 reports
- Neck pain: 518 reports
- Neoplasm malignant (cancer tumour): 220 reports
- Nephrogenic anaemia (anaemia due to kidney disease): 109 reports
- Nervousness: 261 reports
- Neuralgia (pain in one or more nerves): 379 reports
- Neuropathy peripheral (surface nerve damage): 595 reports
- Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 340 reports
- Night sweats (sweating in night): 190 reports
- Non-accidental overdose: 101 reports
- Nosebleed (bleeding from nose): 455 reports
- Oedema (fluid collection in tissue): 258 reports
- Oedema peripheral (superficial swelling): 879 reports
- Oral candidiasis (fungal infection of mouth): 167 reports
- Oropharyngeal pain: 1,001 reports
- Osteoarthritis (a joint disease caused by cartilage loss in a joint): 500 reports
- Osteopenia (a condition where bone mineral density is lower than normal): 145 reports
- Osteoporosis (bones weak and more likely to break): 440 reports
- Otitis (ear infection): 851 reports
- Overdose: 1,298 reports
- Oxygen saturation decreased: 1,922 reports
- Pain: 5,088 reports
- Pain in extremity: 2,188 reports
- Pain in jaw: 172 reports
- Pancreatitis (inflammation of pancreas): 288 reports
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 358 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 675 reports
- Peripheral coldness: 115 reports
- Peripheral swelling: 1,571 reports
- Photophobia (extreme sensitivity to light): 124 reports
- Pleural effusion (water on the lungs): 496 reports
- Pneumonia: 3,573 reports
- Poisoning: 320 reports
- Poor venous access: 518 reports
- Post-traumatic stress disorder: 149 reports
- Productive cough: 990 reports
- Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells): 125 reports
- Protein - urine: 116 reports
- Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 114 reports
- Psoriasis (immune-mediated disease that affects the skin): 272 reports
- Psychological trauma: 122 reports
- Pulmonary congestion (congestion in the lungs): 225 reports
- Pulmonary embolism (blockage of the main artery of the lung): 420 reports
- Pulmonary oedema (fluid accumulation in the lungs): 563 reports
- Rales (an abnormal respiratory sound characterized by fine crackles): 134 reports
- Rash erythematous (redness of the skin): 676 reports
- Rashes (redness): 5,569 reports
- Rash macular (small, flat red spots): 145 reports
- Rash maculo-papular (red area on the skin that is covered with small confluent bumps): 127 reports
- Rectal haemorrhage (bleeding from anus): 257 reports
- Red blood cell count decreased: 276 reports
- Renal disorder (kidney disease): 218 reports
- Renal failure acute (rapid kidney dysfunction): 251 reports
- Renal impairment (severely reduced kidney function): 287 reports
- Renal injury (kidney injury): 150 reports
- Renal tubular necrosis (death of kidney tubules): 128 reports
- Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 496 reports
- Respiratory depression (respiration has a rate below 12 breaths): 132 reports
- Respiratory disorder (respiratory disease): 229 reports
- Respiratory distress (difficulty in breathing): 297 reports
- Respiratory rate increased (excess breathing rate/min): 456 reports
- Respiratory tract congestion (blockage on respiratory system): 125 reports
- Restless leg syndrome (a powerful urge to move your legs): 206 reports
- Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 204 reports
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 2,952 reports
- Road traffic accident: 287 reports
- Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 126 reports
- Scab (a hard coating on the skin formed during the wound healing): 110 reports
- Sedation: 146 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 885 reports
- Septic shock (shock due to blood infection): 270 reports
- Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 156 reports
- Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 111 reports
- Sinusitis (inflammation of sinus): 4,178 reports
- Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 231 reports
- Skin blushing/flushing (a sudden reddening of the face, neck): 1,241 reports
- Skin - clammy: 124 reports
- Skin discoloration: 333 reports
- Skin fissures (a crack in the skin): 106 reports
- Skin reaction: 112 reports
- Skin ulcer: 275 reports
- Sleep apnea syndrome: 305 reports
- Sleep disorder: 277 reports
- Speech disorder: 182 reports
- Speech impairment (adult) (inability to speak (adult)): 352 reports
- Stable angina (a constant chest pain): 205 reports
- Staphylococcal infection (an infection with staphylococcus bacteria): 368 reports
- Stomatitis (inflammation of mucous membrane of mouth): 511 reports
- Stress and anxiety: 2,169 reports
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 368 reports
- Suicidal ideation: 370 reports
- Suicide attempt: 402 reports
- Swallowing difficulty: 738 reports
- Swelling: 955 reports
- Swelling face: 322 reports
- Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 166 reports
- Tachypnea: 173 reports
- Taste - impaired: 227 reports
- The flu (the flu is caused by an influenza virus): 1,561 reports
- Therapeutic response decreased (less preventive response): 420 reports
- Throat irritation: 987 reports
- Thrombocytopenia (decrease of platelets in blood): 1,296 reports
- Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot): 105 reports
- Tinnitus (a ringing in the ears): 181 reports
- Toothaches (tooth pain): 214 reports
- Tooth disorder (tooth disease): 422 reports
- Transaminases increased: 168 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 843 reports
- Tumor: 261 reports
- Type 2 diabetes: 184 reports
- Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 163 reports
- Upper limb fracture: 160 reports
- Upper respiratory tract infection: 1,323 reports
- Urinary tract infection: 2,505 reports
- Urination - painful: 203 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 1,469 reports
- Uveitis (inflammation of the uvea): 159 reports
- Vasculitis (inflammation of a blood vessel or blood vessels): 263 reports
- Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 159 reports
- Viral infection: 448 reports
- Vision blurred: 443 reports
- Visual impairment: 356 reports
- Weakness: 2,567 reports
- Weight decreased: 2,799 reports
- Weight fluctuation: 182 reports
- Weight increased: 4,249 reports
- White blood cell count decreased: 905 reports
- White blood cell count increased: 377 reports
- Wound: 330 reports
Browse all side effects of Hydramine:
a b c d e f g h i j k l m n o p q r s t u v w x y zRestless leg syndrome treatments and more:
- Restless leg syndrome (41,962 reports)
COVID vaccines that are related to Restless leg syndrome:
- Restless leg syndrome in Moderna COVID Vaccine
- Restless leg syndrome in Pfizer BioNTech Covid Vaccine
- Restless leg syndrome in Johnson and Johnson Covid Vaccine
Common drugs associated with Restless leg syndrome:
- Abilify: 423 reports
- Acetaminophen: 153 reports
- Acetylsalicylic acid: 221 reports
- Aciphex: 105 reports
- Actemra: 124 reports
- Actonel: 106 reports
- Adderall: 252 reports
- Advair diskus 100/50: 132 reports
- Advair hfa: 109 reports
- Advil: 120 reports
- Albuterol: 340 reports
- Albuterol sulfate: 102 reports
- Alendronate sodium: 277 reports
- Aleve: 108 reports
- Allegra: 182 reports
- Allopurinol: 205 reports
- Alprazolam: 219 reports
- Ambien: 476 reports
- Amlodipine: 283 reports
- Amoxicillin: 151 reports
- Ampyra: 148 reports
- Aredia: 183 reports
- Aripiprazole: 157 reports
- Aspirin: 900 reports
- Atenolol: 281 reports
- Ativan: 327 reports
- Atrovent: 113 reports
- Aubagio: 107 reports
- Avonex: 268 reports
- Baclofen: 246 reports
- Benadryl: 280 reports
- Calcium: 263 reports
- Carvedilol: 127 reports
- Celebrex: 340 reports
- Celexa: 214 reports
- Chantix: 180 reports
- Claritin: 178 reports
- Clonazepam: 679 reports
- Clonidine: 124 reports
- Clopra: 842 reports
- Codeine: 121 reports
- Colace: 159 reports
- Coumadin: 359 reports
- Cozaar: 119 reports
- Crestor: 321 reports
- Crysvita: 243 reports
- Cymbalta: 754 reports
- Decadron: 101 reports
- Depakote: 154 reports
- Diazepam: 307 reports
- Dilaudid: 103 reports
- Diovan: 171 reports
- Diphen: 149 reports
- Doxycycline: 143 reports
- Duragesic: 152 reports
- Duragesic-100: 104 reports
- Effexor: 485 reports
- Effexor xr: 155 reports
- Elavil: 102 reports
- Eliquis: 112 reports
- Enbrel: 301 reports
- Escitalopram: 198 reports
- Fentanyl: 182 reports
- Fish oil: 247 reports
- Flexeril: 194 reports
- Flomax: 111 reports
- Flonase: 217 reports
- Fluoxetine: 355 reports
- Folic acid: 153 reports
- Forteo: 217 reports
- Fosamax: 892 reports
- Furosemide: 423 reports
- Gabapentin: 882 reports
- Geodon: 116 reports
- Gilenya: 266 reports
- Humalog: 131 reports
- Humira: 424 reports
- Hydramine: 206 reports
- Hydrochlorothiazide: 383 reports
- Hydrocodone bitartrate and acetaminophen: 111 reports
- Ibu: 470 reports
- Ibuprofen: 427 reports
- Klonopin: 384 reports
- Klor-con: 106 reports
- Lamictal: 213 reports
- Lamotrigine: 143 reports
- Lansoprazole: 137 reports
- Lantus: 171 reports
- Lasix: 450 reports
- Latuda: 145 reports
- Levaquin: 166 reports
- Levothyroxine sodium: 214 reports
- Lexapro: 387 reports
- Lipitor: 574 reports
- Lisinopril: 571 reports
- Lopurin: 205 reports
- Loratadine: 135 reports
- Loraz: 497 reports
- Lorazepam: 446 reports
- Lortab: 196 reports
- Losartan: 203 reports
- Lunesta: 105 reports
- Lyrica: 829 reports
- Magnesium: 271 reports
- Melatonin: 223 reports
- Meloxicam: 166 reports
- Metformin: 510 reports
- Methotrexate: 384 reports
- Metoclopramide: 840 reports
- Metoclopramide hydrochloride: 178 reports
- Metoprolol tartrate: 150 reports
- Miralax: 125 reports
- Mirapex: 495 reports
- Mirtazapine: 548 reports
- Modafinil: 143 reports
- Morphine: 331 reports
- Motrin: 102 reports
- Multivitamin: 177 reports
- Naproxen: 101 reports
- Nasonex: 113 reports
- Neupro: 213 reports
- Neurontin: 477 reports
- Nexium: 458 reports
- Norco: 147 reports
- Norvasc: 224 reports
- Nuvigil: 158 reports
- Olanzapine: 144 reports
- Omeprazole: 712 reports
- Ondansetron: 145 reports
- Opsumit: 121 reports
- Oxycodone: 253 reports
- Oxycontin: 286 reports
- Pantoprazole: 299 reports
- Paracetamol: 137 reports
- Paroxetine: 220 reports
- Paxil: 267 reports
- Pepcid: 139 reports
- Percocet: 311 reports
- Phenergan: 126 reports
- Plaquenil: 146 reports
- Plavix: 210 reports
- Potassium: 113 reports
- Prednisone: 595 reports
- Pregabalin: 133 reports
- Premarin: 207 reports
- Prevacid: 214 reports
- Prilosec: 387 reports
- Profen: 427 reports
- Promethazine: 108 reports
- Protonix: 272 reports
- Provigil: 134 reports
- Prozac: 329 reports
- Pulmicort: 119 reports
- Quetiapine fumarate: 115 reports
- Ramipril: 164 reports
- Ranitidine: 183 reports
- Reglan: 362 reports
- Remicade: 108 reports
- Requip: 803 reports
- Restoril: 102 reports
- Revlimid: 195 reports
- Risperdal: 212 reports
- Ritalin: 122 reports
- Saphris: 108 reports
- Seroquel: 678 reports
- Sertraline: 425 reports
- Simvastatin: 356 reports
- Sinemet: 170 reports
- Singulair: 327 reports
- Spiriva: 232 reports
- Spironolactone: 182 reports
- Suboxone: 117 reports
- Symbicort: 158 reports
- Synthroid: 574 reports
- Tecfidera: 114 reports
- Temaz: 141 reports
- Temazepam: 141 reports
- Topamax: 182 reports
- Topiramate: 102 reports
- Toprol-xl: 115 reports
- Tramadol: 591 reports
- Tylenol: 417 reports
- Tysabri: 196 reports
- Ultram: 125 reports
- Valium: 197 reports
- Vicodin: 248 reports
- Vioxx: 314 reports
- Vitamin b12: 285 reports
- Vitamin c: 186 reports
- Vitamin d: 515 reports
- Vitamin d3: 249 reports
- Vitamins: 252 reports
- Vivitrol: 111 reports
- Wellbutrin: 403 reports
- Xanax: 478 reports
- Xeljanz: 103 reports
- Xtandi: 198 reports
- Xyrem: 831 reports
- Zantac: 208 reports
- Zetia: 121 reports
- Zide: 384 reports
- Zocor: 235 reports
- Zofran: 237 reports
- Zoloft: 437 reports
- Zolpidem: 230 reports
- Zometa: 268 reports
- Zopiclone: 193 reports
- Zyprexa: 158 reports
- Zyrtec: 237 reports
All the drugs that are associated with Restless leg syndrome:
- Restless leg syndrome (2,312 drugs)
Common conditions associated with Restless leg syndrome:
- Acid reflux: 450 reports
- Acupuncture and pain: 549 reports
- Adult hypothyroidism: 246 reports
- Alternative medicine - pain relief: 976 reports
- Antidepressant therapy: 1,489 reports
- Anxiety: 707 reports
- Anxiety aggravated: 707 reports
- Anxiety and stress: 707 reports
- Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 707 reports
- Apprehension: 707 reports
- Arthritis: 232 reports
- Arthritis - rheumatoid: 661 reports
- Asthma: 305 reports
- Back pain: 234 reports
- Back pain - nonspecific: 234 reports
- Bipolar: 496 reports
- Bi-polar: 496 reports
- Bipolar 1: 108 reports
- Bipolar disorder: 496 reports
- Blood cholesterol abnormal: 618 reports
- Blood cholesterol increased: 618 reports
- Blood pressure abnormal: 187 reports
- Blood pressure - high: 777 reports
- Blood pressure increased: 701 reports
- Blood triglycerides abnormal: 618 reports
- Blood triglycerides increased: 618 reports
- Bronchial asthma: 298 reports
- Cancer - prostate: 192 reports
- Cannot sleep: 485 reports
- Can't sleep: 456 reports
- Cardiac disorder: 124 reports
- Cataplexy: 315 reports
- Cessation of smoking: 146 reports
- Chronic asthma: 298 reports
- Chronic obstructive airway disease: 108 reports
- Chronic obstructive pulmonary disease: 108 reports
- Copd: 108 reports
- Crohns: 178 reports
- Crohn's disease: 178 reports
- Crohns disease: 178 reports
- Crohn's disease aggravated: 178 reports
- Daytime sleep disorder: 660 reports
- Depression: 1,489 reports
- Depression aggravated: 1,489 reports
- Depression - major: 229 reports
- Diabetes: 254 reports
- Diabetes mellitus: 255 reports
- Diabetes mellitus management: 270 reports
- Diabetes - type 2: 150 reports
- Diabetic type 2: 150 reports
- Dm: 254 reports
- Drug dependence: 143 reports
- Dyslipidemia: 660 reports
- Dyspepsia: 140 reports
- Dyssomnia: 456 reports
- Excessive sleepiness: 400 reports
- Exercise-induced asthma: 298 reports
- Familial primary pulmonary hypertension: 257 reports
- Feeling uptight: 707 reports
- Fibromyalgia: 341 reports
- Fibromyalgia syndrome: 341 reports
- Fibromyositis: 341 reports
- Fibrositis: 341 reports
- Gastroesophageal reflux disease: 450 reports
- Gastro-oesophageal reflux disease: 420 reports
- Gastrooesophageal reflux disease: 450 reports
- Gerd: 420 reports
- Gerds: 420 reports
- Glucose test: 204 reports
- Granulomatous ileocolitis: 178 reports
- Hbp: 701 reports
- Headache: 107 reports
- Headaches: 113 reports
- Heartburn: 424 reports
- Heartburn - chronic: 450 reports
- Hepatitis c: 119 reports
- High blood cholesterol: 618 reports
- High blood cholesterol and triglycerides: 618 reports
- High blood pressure: 701 reports
- High cholesterol: 618 reports
- Htn: 701 reports
- Hypercholesterolaemia: 618 reports
- Hypercholesterolemia: 618 reports
- Hyperlipidemia: 660 reports
- Hyperlipoproteinemia: 618 reports
- Hypertension: 703 reports
- Hypertension aggravated: 703 reports
- Hypothyroid: 240 reports
- Hypothyroidism: 240 reports
- Hypothyroids: 240 reports
- Hypothyroidy: 240 reports
- Inability to sleep: 456 reports
- Indigestion: 140 reports
- Inflammatory bowel disease - crohn's disease: 178 reports
- Insomnia: 456 reports
- Insomnia concerns: 485 reports
- Insomnia exacerbated: 456 reports
- Insomnolence: 456 reports
- Jitters: 707 reports
- Joint inflammation: 222 reports
- Ldl/hdl ratio increased: 618 reports
- Lipid disorders: 660 reports
- Lipid test: 618 reports
- Lipoprotein test: 618 reports
- Lower cholesterol: 472 reports
- Low thyroid: 240 reports
- Major depression: 245 reports
- Major depressive disorder: 230 reports
- Migraine: 235 reports
- Migraines: 235 reports
- Ms: 1,014 reports
- Ms hug: 1,014 reports
- Multiple myeloma: 200 reports
- Multiple sclerosis: 1,014 reports
- Muscle spasm: 234 reports
- Muscle spasms: 234 reports
- Myofascial pain syndrome: 341 reports
- Myxedema: 246 reports
- Narcolepsy: 660 reports
- Nausea: 181 reports
- Nerve pain: 191 reports
- Neuralgia: 191 reports
- Neuropathy peripheral: 163 reports
- Niddm: 150 reports
- Nocturnal myoclonus: 1,066 reports
- Non-cardiac chest pain: 420 reports
- Osteopenia: 295 reports
- Osteoporosis: 948 reports
- Pain: 909 reports
- Pain management: 907 reports
- Pain relief: 907 reports
- Panic attack: 122 reports
- Panic attacks: 122 reports
- Panic disorder: 131 reports
- Paralysis agitans: 355 reports
- Parkinson: 115 reports
- Parkinsonism: 355 reports
- Parkinsons: 115 reports
- Parkinson's disease: 356 reports
- Parkinson's disease aggravated: 356 reports
- Periodic limb movement disorder: 1,066 reports
- Plaque psoriasis: 153 reports
- Plasma cell myeloma: 200 reports
- Plmd: 1,066 reports
- Postherpetic neuralgia: 191 reports
- Post traumatic stress disorder: 128 reports
- Post-traumatic stress disorder: 107 reports
- Primary pulmonary hypertension: 257 reports
- Prostate cancer: 192 reports
- Psoriasis: 153 reports
- Psoriasis aggravated: 153 reports
- Psoriatic arthropathy: 139 reports
- Psoriatic arthropathy aggravated: 139 reports
- Psychotic disorder: 117 reports
- Ptsd: 128 reports
- Pulmonary arterial hypertension: 257 reports
- Pulmonary hypertension: 103 reports
- Pyrosis: 420 reports
- Quit smoking: 146 reports
- Ra: 661 reports
- Reduce cholesterol: 571 reports
- Reflux: 450 reports
- Reflux esophagitis: 420 reports
- Regional enteritis: 178 reports
- Restless leg: 1,513 reports
- Restless legs: 1,450 reports
- Restless legs syndrome: 1,450 reports
- Restless leg syndrome: 1,450 reports
- Rheumatoid arthritis: 661 reports
- Rls: 1,513 reports
- Schizophrenia: 193 reports
- Sleep aid: 456 reports
- Sleep disorder: 400 reports
- Sleep disorder due to a general medical condition: 400 reports
- Sleep disorder due to general medical condition, insomnia type: 400 reports
- Sleep disorder therapy: 400 reports
- Sleeping: 485 reports
- Sleeping difficulty: 456 reports
- Sleep issues: 456 reports
- Sleeplessness: 485 reports
- Sleep - too much: 400 reports
- Smoker: 146 reports
- Smoking and smokeless tobacco: 146 reports
- Smoking cessation: 146 reports
- Smoking cessation therapy: 146 reports
- Stomach upset: 140 reports
- Stop smoking: 146 reports
- Stress: 707 reports
- Stress and anxiety: 707 reports
- Tension: 707 reports
- Thin bones: 908 reports
- Thyroid: 119 reports
- Thyroid diseases: 153 reports
- Thyroid disorder: 153 reports
- Thyroide: 149 reports
- Thyroid function test abnormal: 149 reports
- Tobacco abuse: 146 reports
- Tobacco user: 146 reports
- Type 2 diabetes: 150 reports
- Type 2 diabetes mellitus: 150 reports
- Underactive thyroid: 240 reports
- Under active thyroids: 240 reports
- Unipolar depression: 229 reports
- Wakefulness: 456 reports
All the conditions that are associated with Restless leg syndrome:
- Restless leg syndrome (1,739 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Contrave and Paroxetine drug interaction - now
- Lexapro and Skin Striae - 2 seconds ago
- Tizanidine Hydrochloride and Skin Ulcer - 4 seconds ago
- Zanaflex and Skin Injury - 6 seconds ago
- Zanaflex and Skin Swelling - 6 seconds ago
- Rabeprazole Sodium and Ankle Fracture - 25 seconds ago
- Sugammadex Sodium and Post-Traumatic Stress Disorder - 35 seconds ago
- Sugammadex Sodium and Post Traumatic Stress Disorder - 35 seconds ago
- Depression in Hydrodiuril, how severe and when it was recovered? - 39 seconds ago
- Fluconazole and Carcinoid Tumor Of The Small Bowel - 56 seconds ago