Hydrea and Choledocholithiasis - a phase IV clinical study of FDA data


We study 8,676 people who have side effects when taking Hydrea. Choledocholithiasis is found, especially among people who are female, 60+ old, also take Forteo and have Primary myelofibrosis.

The phase IV clinical study analyzes which people take Hydrea and have Choledocholithiasis. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2023

8,676 people reported to have side effects when taking Hydrea.
Among them, 13 people (0.15%) have Choledocholithiasis.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is used in polycythemia vera. Currently, eHealthMe is studying from 8,830 Hydrea users.

What is Choledocholithiasis?

Choledocholithiasis (stones in the common bile duct) is found to be associated with 1,481 drugs and 919 conditions by eHealthMe. Currently, we are studying 4,398 people who have Choledocholithiasis.

Number of Hydrea and Choledocholithiasis reports submitted per year:

Could Hydrea cause Choledocholithiasis?

Gender of people who have Choledocholithiasis when taking Hydrea *:

  • female: 66.67 %
  • male: 33.33 %

Age of people who have Choledocholithiasis when taking Hydrea *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 16.67 %
  • 50-59: 0.0 %
  • 60+: 83.33 %

Common drugs people take besides Hydrea *:

  1. Prolia: 4 people, 30.77%
  2. Fosamax: 4 people, 30.77%
  3. Forteo: 4 people, 30.77%
  4. Lasix: 3 people, 23.08%
  5. Jakafi: 3 people, 23.08%
  6. Exjade: 1 person, 7.69%

Common side effects people have besides Choledocholithiasis *:

  1. Abdominal Pain: 8 people, 61.54%
  2. Weakness: 8 people, 61.54%
  3. Thrombocytopenia (decrease of platelets in blood): 8 people, 61.54%
  4. Diarrhea: 8 people, 61.54%
  5. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 8 people, 61.54%
  6. Haemoglobin Decreased: 8 people, 61.54%
  7. Fatigue (feeling of tiredness): 8 people, 61.54%
  8. Splenomegaly (enlargement of spleen): 6 people, 46.15%
  9. White Blood Cell Count Increased: 4 people, 30.77%
  10. Gallbladder Disorder: 4 people, 30.77%

Common conditions people have *:

  1. Primary Myelofibrosis (primary disorder of the bone marrow): 9 people, 69.23%
  2. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 30.77%
  3. Iron Overload: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrea and have Choledocholithiasis?

Check whether Choledocholithiasis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Hydrea side effects by duration, gender and age:

Choledocholithiasis treatments and more:

Common drugs associated with Choledocholithiasis:

All the drugs that are associated with Choledocholithiasis:

Common conditions associated with Choledocholithiasis:

All the conditions that are associated with Choledocholithiasis:

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyurea (the active ingredients of Hydrea) and Hydrea (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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