Hydrochlorothiazide and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Hydrochlorothiazide, especially for people who are male, 60+ old.

The phase IV clinical study analyzes which people take Hydrochlorothiazide and have Dupuytren's contracture. It is created by eHealthMe based on reports of 156,575 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 17, 2022

156,575 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 12 people (0.01%) have Dupuytren's contracture.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 148,540 Hydrochlorothiazide users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 445 drugs and 208 conditions by eHealthMe.

Number of Hydrochlorothiazide and Dupuytren's contracture reports submitted per year:

Could Hydrochlorothiazide cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking Hydrochlorothiazide *:

  • female: 50 %
  • male: 50 %

Age of people who have Dupuytren's contracture when taking Hydrochlorothiazide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 22.22 %
  • 50-59: 22.22 %
  • 60+: 55.56 %

Common drugs people take besides Hydrochlorothiazide *:

  1. Lopressor: 5 people, 41.67%
  2. Zometa: 3 people, 25.00%
  3. Desyrel: 3 people, 25.00%
  4. Lisinopril: 3 people, 25.00%
  5. Levaquin: 3 people, 25.00%
  6. Leuprolide Acetate: 3 people, 25.00%
  7. Klor-Con: 3 people, 25.00%
  8. Mitoxantrone: 3 people, 25.00%
  9. Motrin: 3 people, 25.00%
  10. Neupogen: 3 people, 25.00%

Common side effects people have besides Dupuytren's contracture *:

  1. Gait Disturbance: 7 people, 58.33%
  2. Breathing Difficulty: 6 people, 50.00%
  3. Nausea (feeling of having an urge to vomit): 5 people, 41.67%
  4. Stress And Anxiety: 5 people, 41.67%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 41.67%
  6. Pleural Effusion (water on the lungs): 4 people, 33.33%
  7. Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 33.33%
  8. Gingival Bleeding (bleeding gums): 3 people, 25.00%
  9. Face Injury: 3 people, 25.00%
  10. Faecal Incontinence (a lack of control over passing stool): 3 people, 25.00%

Common conditions people have *:

  1. Vitamin B Complex Deficiency: 2 people, 16.67%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
  3. Prostate Cancer: 2 people, 16.67%
  4. Hypersensitivity: 2 people, 16.67%
  5. Headache (pain in head): 2 people, 16.67%
  6. Diabetes: 2 people, 16.67%
  7. Bone Density Decreased: 2 people, 16.67%
  8. Type 2 Diabetes: 1 person, 8.33%
  9. Metastases To Bone (cancer spreads to bone): 1 person, 8.33%
  10. Immunodeficiency Common Variable: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of hydrochlorothiazide:

Alternative drugs to, pros and cons of Hydrochlorothiazide:

Common Hydrochlorothiazide side effects:

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

Common conditions associated with Dupuytren's contracture:

  • Ra: 104 reports

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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