Hydroxyzine and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Hydroxyzine, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Hydroxyzine and have Dupuytren's contracture. It is created by eHealthMe based on reports of 40,735 people who have side effects when taking Hydroxyzine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 17, 2022

40,735 people reported to have side effects when taking Hydroxyzine.
Among them, 21 people (0.05%) have Dupuytren's contracture.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 36,931 Hydroxyzine users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 445 drugs and 208 conditions by eHealthMe.

Number of Hydroxyzine and Dupuytren's contracture reports submitted per year:

Could Hydroxyzine cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking Hydroxyzine *:

  • female: 88.24 %
  • male: 11.76 %

Age of people who have Dupuytren's contracture when taking Hydroxyzine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 12.5 %
  • 50-59: 0.0 %
  • 60+: 87.5 %

Common drugs people take besides Hydroxyzine *:

  1. Metformin: 19 people, 90.48%
  2. Synthroid: 17 people, 80.95%
  3. Vitamin B6: 16 people, 76.19%
  4. Januvia: 16 people, 76.19%
  5. Demerol: 14 people, 66.67%
  6. Crestor: 11 people, 52.38%
  7. Janumet: 11 people, 52.38%
  8. Plaquenil: 10 people, 47.62%
  9. Tylenol: 10 people, 47.62%
  10. Rituxan: 8 people, 38.10%

Common side effects people have besides Dupuytren's contracture *:

  1. Dizziness: 19 people, 90.48%
  2. Chest Pain: 19 people, 90.48%
  3. Joint Pain: 19 people, 90.48%
  4. Cough: 19 people, 90.48%
  5. Nausea (feeling of having an urge to vomit): 19 people, 90.48%
  6. Asthma: 19 people, 90.48%
  7. Blood Pressure Diastolic Abnormal: 17 people, 80.95%
  8. Blood Pressure Fluctuation: 17 people, 80.95%
  9. Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 17 people, 80.95%
  10. Aortic Stenosis (obstruction to the outflow of blood from the left ventricle into the aorta): 17 people, 80.95%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 19 people, 90.48%
  2. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 17 people, 80.95%
  3. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 16 people, 76.19%
  4. Myositis (inflammation of the muscles): 16 people, 76.19%
  5. Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 16 people, 76.19%
  6. Vasculitis (inflammation of a blood vessel or blood vessels): 15 people, 71.43%
  7. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 9.52%
  8. Psoriasis (immune-mediated disease that affects the skin): 2 people, 9.52%
  9. Hypersensitivity: 2 people, 9.52%
  10. Headache (pain in head): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyzine and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of hydroxyzine hydrochloride:

Alternative drugs to, pros and cons of Hydroxyzine:

Common Hydroxyzine side effects:

Browse all side effects of Hydroxyzine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

Common conditions associated with Dupuytren's contracture:

  • Ra: 104 reports

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyzine hydrochloride (the active ingredients of Hydroxyzine) and Hydroxyzine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: