Imuran and Pathological fracture - a phase IV clinical study of FDA data

Summary:

Pathological fracture is found among people who take Imuran, especially for people who are female, 40-49 old.

The phase IV clinical study analyzes which people take Imuran and have Pathological fracture. It is created by eHealthMe based on reports of 26,904 people who have side effects when taking Imuran from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.



On May, 14, 2022

26,904 people reported to have side effects when taking Imuran.
Among them, 24 people (0.09%) have Pathological fracture.


What is Imuran?

Imuran has active ingredients of azathioprine. It is often used in crohn's disease. eHealthMe is studying from 27,576 Imuran users for its effectiveness, alternative drugs and more.

What is Pathological fracture?

Pathological fracture (broken bone caused by disease) is found to be associated with 1,093 drugs and 456 conditions by eHealthMe.

Number of Imuran and Pathological fracture reports submitted per year:

Could Imuran cause Pathological fracture?

Gender of people who have Pathological fracture when taking Imuran *:

  • female: 91.67 %
  • male: 8.33 %

Age of people who have Pathological fracture when taking Imuran *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 5.56 %
  • 20-29: 5.56 %
  • 30-39: 0.0 %
  • 40-49: 72.22 %
  • 50-59: 5.56 %
  • 60+: 11.11 %

Common drugs people take besides Imuran *:

  1. Zometa: 18 people, 75.00%
  2. Aredia: 18 people, 75.00%
  3. Lortab: 16 people, 66.67%
  4. Diflucan: 16 people, 66.67%
  5. Amoxicillin: 16 people, 66.67%
  6. Nexium: 15 people, 62.50%
  7. Bactrim Ds: 15 people, 62.50%
  8. Clonidine: 15 people, 62.50%
  9. Restoril: 14 people, 58.33%
  10. Dexamethasone: 14 people, 58.33%

Common side effects people have besides Pathological fracture *:

  1. Osteonecrosis Of Jaw (death of bone of jaw): 18 people, 75.00%
  2. Atelectasis (partial or complete collapse of the lung): 18 people, 75.00%
  3. Hypokalemia (low potassium): 18 people, 75.00%
  4. Mucosal Inflammation (infection of mucous membrane): 18 people, 75.00%
  5. Pain: 18 people, 75.00%
  6. Pleural Effusion (water on the lungs): 18 people, 75.00%
  7. Hyperkalemia (damage to or disease of the kidney): 17 people, 70.83%
  8. Inflammation: 17 people, 70.83%
  9. Chest Pain: 17 people, 70.83%
  10. Pneumonia: 17 people, 70.83%

Common conditions people have *:

  1. High Blood Pressure: 15 people, 62.50%
  2. Multiple Myeloma (cancer of the plasma cells): 14 people, 58.33%
  3. Anaemia (lack of blood): 7 people, 29.17%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 29.17%
  5. Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 7 people, 29.17%
  6. Osteoporosis (bones weak and more likely to break): 4 people, 16.67%
  7. Metastases To Bone (cancer spreads to bone): 2 people, 8.33%
  8. Breast Cancer: 1 person, 4.17%
  9. Diabetes: 1 person, 4.17%
  10. Gastric Disorder (disease of stomach): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Imuran and have Pathological fracture?

Check whether Pathological fracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Imuran:

Pathological fracture treatments and more:

COVID vaccines that are related to Pathological fracture:

How severe was Pathological fracture and when was it recovered:

Expand to all the drugs that have ingredients of azathioprine:

Common drugs associated with Pathological fracture:

All the drugs that are associated with Pathological fracture:

Common conditions associated with Pathological fracture:

All the conditions that are associated with Pathological fracture:

How the study uses the data?

The study uses data from the FDA. It is based on azathioprine (the active ingredients of Imuran) and Imuran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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