Indapamide and Renal tubular necrosis - a phase IV clinical study of FDA data


Renal tubular necrosis is found among people who take Indapamide, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Indapamide and have Renal tubular necrosis. It is created by eHealthMe based on reports of 18,261 people who have side effects when taking Indapamide from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

18,261 people reported to have side effects when taking Indapamide.
Among them, 15 people (0.08%) have Renal tubular necrosis.

What is Indapamide?

Indapamide has active ingredients of indapamide. It is often used in high blood pressure. eHealthMe is studying from 18,714 Indapamide users for its effectiveness, alternative drugs and more.

What is Renal tubular necrosis?

Renal tubular necrosis (death of kidney tubules) is found to be associated with 1,604 drugs and 906 conditions by eHealthMe.

Number of Indapamide and Renal tubular necrosis reports submitted per year:

Could Indapamide cause Renal tubular necrosis?

Time on Indapamide when people have Renal tubular necrosis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Renal tubular necrosis when taking Indapamide *:

  • female: 60 %
  • male: 40 %

Age of people who have Renal tubular necrosis when taking Indapamide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 6.67 %
  • 40-49: 0.0 %
  • 50-59: 6.67 %
  • 60+: 86.67 %

Common drugs people take besides Indapamide *:

  1. Actonel: 5 people, 33.33%
  2. Plavix: 4 people, 26.67%
  3. Atripla: 4 people, 26.67%
  4. Tarka: 4 people, 26.67%
  5. Amlodipine: 3 people, 20.00%
  6. Hyzaar: 3 people, 20.00%
  7. Ezetimibe: 2 people, 13.33%
  8. Lasix: 2 people, 13.33%
  9. Losartan Potassium And Hydrochlorothiazide: 2 people, 13.33%
  10. Nateglinide: 2 people, 13.33%

Common side effects people have besides Renal tubular necrosis *:

  1. Renal Failure Acute (rapid kidney dysfunction): 7 people, 46.67%
  2. Interstitial Nephritis (inflammation of the kidney): 6 people, 40.00%
  3. Renal Tubular Disorder (disease of kidney tubules): 3 people, 20.00%
  4. Nausea (feeling of having an urge to vomit): 3 people, 20.00%
  5. Pneumonia: 3 people, 20.00%
  6. Acute Kidney Failure: 3 people, 20.00%
  7. Urinary Tract Infection: 3 people, 20.00%
  8. Nausea And Vomiting: 2 people, 13.33%
  9. Duodenal Perforation (complication of duodenal ulcer): 2 people, 13.33%
  10. Eosinophil Count Increased: 2 people, 13.33%

Common conditions people have *:

  1. Hiv Infection: 4 people, 26.67%
  2. Lung Adenocarcinoma (a form of non-small cell lung cancer): 2 people, 13.33%
  3. High Blood Cholesterol: 2 people, 13.33%
  4. Diabetes: 2 people, 13.33%
  5. Joint Swelling: 1 person, 6.67%
  6. Indigestion: 1 person, 6.67%
  7. Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 6.67%
  8. Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 6.67%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
  10. Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Indapamide and have Renal tubular necrosis?

Check whether Renal tubular necrosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

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Common Indapamide side effects:

Browse all side effects of Indapamide:

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Renal tubular necrosis treatments and more:

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Common drugs associated with Renal tubular necrosis:

All the drugs that are associated with Renal tubular necrosis:

Common conditions associated with Renal tubular necrosis:

All the conditions that are associated with Renal tubular necrosis:

How the study uses the data?

The study uses data from the FDA. It is based on indapamide (the active ingredients of Indapamide) and Indapamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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