Indomethacin and Clostridium difficile colitis - a phase IV clinical study of FDA data


Clostridium difficile colitis is found among people who take Indomethacin, especially for people who are male, 40-49 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Indomethacin and have Clostridium difficile colitis. It is created by eHealthMe based on reports of 13,667 people who have side effects when taking Indomethacin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 22, 2022

13,667 people reported to have side effects when taking Indomethacin.
Among them, 31 people (0.23%) have Clostridium difficile colitis.

What is Indomethacin?

Indomethacin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 14,307 Indomethacin users for its effectiveness, alternative drugs and more.

What is Clostridium difficile colitis?

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection) is found to be associated with 1,939 drugs and 1,597 conditions by eHealthMe.

Number of Indomethacin and Clostridium difficile colitis reports submitted per year:

Could Indomethacin cause Clostridium difficile colitis?

Time on Indomethacin when people have Clostridium difficile colitis *:

  • < 1 month: 25 %
  • 1 - 6 months: 75 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Clostridium difficile colitis when taking Indomethacin *:

  • female: 40.74 %
  • male: 59.26 %

Age of people who have Clostridium difficile colitis when taking Indomethacin *:

  • 0-1: 0.0 %
  • 2-9: 25 %
  • 10-19: 5 %
  • 20-29: 5 %
  • 30-39: 5 %
  • 40-49: 30 %
  • 50-59: 10 %
  • 60+: 20 %

Common drugs people take besides Indomethacin *:

  1. Acetaminophen: 7 people, 22.58%
  2. Ativan: 7 people, 22.58%
  3. Nitroglycerin: 7 people, 22.58%
  4. Omeprazole: 7 people, 22.58%
  5. Lorazepam: 7 people, 22.58%
  6. Folic Acid: 7 people, 22.58%
  7. Septocaine: 6 people, 19.35%
  8. Remeron: 6 people, 19.35%
  9. Reglan: 6 people, 19.35%
  10. Protonix: 6 people, 19.35%

Common side effects people have besides Clostridium difficile colitis *:

  1. High Blood Pressure: 16 people, 51.61%
  2. Osteopenia (a condition where bone mineral density is lower than normal): 16 people, 51.61%
  3. Herpes Zoster: 12 people, 38.71%
  4. Thrombocytopenia (decrease of platelets in blood): 12 people, 38.71%
  5. Cellulitis Staphylococcal (a type of bacteria originated skin soft tissue infection): 12 people, 38.71%
  6. Growth Retardation (delayed growth): 10 people, 32.26%
  7. Breathing Difficulty: 10 people, 32.26%
  8. Dizziness: 10 people, 32.26%
  9. Dental Plaque (film of mucus and bacteria deposited on the teeth that encourages the development of dental caries): 10 people, 32.26%
  10. Fever: 10 people, 32.26%

Common conditions people have *:

  1. Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 12 people, 38.71%
  2. Bone Marrow Conditioning Regimen: 7 people, 22.58%
  3. Multiple Myeloma (cancer of the plasma cells): 6 people, 19.35%
  4. Pain: 5 people, 16.13%
  5. Oral Herpes (viral infection of mouth): 4 people, 12.90%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.90%
  7. Diarrhea: 4 people, 12.90%
  8. Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 3 people, 9.68%
  9. Sleep Disorder: 2 people, 6.45%
  10. Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Indomethacin and have Clostridium difficile colitis?

Check whether Clostridium difficile colitis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Clostridium difficile colitis and when was it recovered:

Expand to all the drugs that have ingredients of indomethacin:

Alternative drugs to, pros and cons of Indomethacin:

Common Indomethacin side effects:

Browse all side effects of Indomethacin:

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Clostridium difficile colitis treatments and more:

COVID vaccines that are related to Clostridium difficile colitis:

Common drugs associated with Clostridium difficile colitis:

All the drugs that are associated with Clostridium difficile colitis:

Common conditions associated with Clostridium difficile colitis:

All the conditions that are associated with Clostridium difficile colitis:

How the study uses the data?

The study uses data from the FDA. It is based on indomethacin (the active ingredients of Indomethacin) and Indomethacin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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