Intron a and Skin discoloration - a phase IV clinical study of FDA data


Skin discoloration is found among people who take Intron a, especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Intron a and have Skin discoloration. It is created by eHealthMe based on reports of 9,274 people who have side effects when taking Intron a from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 22, 2022

9,274 people reported to have side effects when taking Intron a.
Among them, 38 people (0.41%) have Skin discoloration.

What is Intron a?

Intron a has active ingredients of interferon alfa-2b. eHealthMe is studying from 9,291 Intron a users for its effectiveness, alternative drugs and more.

What is Skin discoloration?

Skin discoloration is found to be associated with 2,130 drugs and 1,309 conditions by eHealthMe.

Number of Intron a and Skin discoloration reports submitted per year:

Could Intron a cause Skin discoloration?

Time on Intron a when people have Skin discoloration *:

  • < 1 month: 20 %
  • 1 - 6 months: 60 %
  • 6 - 12 months: 20 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Skin discoloration when taking Intron a *:

  • female: 54.05 %
  • male: 45.95 %

Age of people who have Skin discoloration when taking Intron a *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 7.14 %
  • 40-49: 39.29 %
  • 50-59: 32.14 %
  • 60+: 21.43 %

Common drugs people take besides Intron a *:

  1. Rebetol: 14 people, 36.84%
  2. Ribavirin: 7 people, 18.42%
  3. Soma: 2 people, 5.26%
  4. Zerit: 1 person, 2.63%
  5. Glucophage: 1 person, 2.63%
  6. Hydroxyzine: 1 person, 2.63%
  7. Hydrochlorothiazide: 1 person, 2.63%
  8. Heparin: 1 person, 2.63%
  9. Fluorouracil: 1 person, 2.63%
  10. Micardis: 1 person, 2.63%

Common side effects people have besides Skin discoloration *:

  1. Fatigue (feeling of tiredness): 8 people, 21.05%
  2. Weight Decreased: 7 people, 18.42%
  3. Weakness: 6 people, 15.79%
  4. Dry Skin: 5 people, 13.16%
  5. Depression: 4 people, 10.53%
  6. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 10.53%
  7. Peripheral Coldness: 4 people, 10.53%
  8. Dizziness: 4 people, 10.53%
  9. Memory Loss: 3 people, 7.89%
  10. Hair Loss: 3 people, 7.89%

Common conditions people have *:

  1. Hepatitis C: 5 people, 13.16%
  2. Plasmacytoma (neoplasm of plasma cells (usually in bone marrow)): 1 person, 2.63%
  3. Malignant Melanoma Stage Iv (the cancer has spread to other places in the body, such as the lung, liver, brain, bone, soft tissue, or gastrointestinal (gi) tract. cancer may have spread to places in the skin far away from where it first started): 1 person, 2.63%
  4. Back Pain: 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Intron a and have Skin discoloration?

Check whether Skin discoloration is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Skin discoloration and when was it recovered:

Expand to all the drugs that have ingredients of interferon alfa-2b:

Alternative drugs to, pros and cons of Intron a:

Common Intron a side effects:

Browse all side effects of Intron a:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Skin discoloration treatments and more:

COVID vaccines that are related to Skin discoloration:

Common drugs associated with Skin discoloration:

All the drugs that are associated with Skin discoloration:

Common conditions associated with Skin discoloration:

All the conditions that are associated with Skin discoloration:

How the study uses the data?

The study uses data from the FDA. It is based on interferon alfa-2b (the active ingredients of Intron a) and Intron a (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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