Invega sustenna and Anhedonia - a phase IV clinical study of FDA data


Anhedonia is found among people who take Invega sustenna, especially for people who are male, 20-29 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Invega sustenna and have Anhedonia. It is created by eHealthMe based on reports of 18,578 people who have side effects when taking Invega sustenna from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jul, 19, 2022

18,578 people reported to have side effects when taking Invega sustenna.
Among them, 44 people (0.24%) have Anhedonia.

What is Invega sustenna?

Invega sustenna has active ingredients of paliperidone palmitate. It is often used in schizoaffective disorder. eHealthMe is studying from 18,669 Invega sustenna users for its effectiveness, alternative drugs and more.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,995 drugs and 1,167 conditions by eHealthMe.

Number of Invega sustenna and Anhedonia reports submitted per year:

Could Invega sustenna cause Anhedonia?

Time on Invega sustenna when people have Anhedonia *:

  • < 1 month: 56.25 %
  • 1 - 6 months: 31.25 %
  • 6 - 12 months: 12.5 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Anhedonia when taking Invega sustenna *:

  • female: 22.22 %
  • male: 77.78 %

Age of people who have Anhedonia when taking Invega sustenna *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 13.04 %
  • 20-29: 65.22 %
  • 30-39: 13.04 %
  • 40-49: 4.35 %
  • 50-59: 0.0 %
  • 60+: 4.35 %

Common drugs people take besides Invega sustenna *:

  1. Risperdal: 4 people, 9.09%
  2. Wellbutrin: 4 people, 9.09%
  3. Abilify: 3 people, 6.82%
  4. Adderall: 3 people, 6.82%
  5. Prozac: 3 people, 6.82%
  6. Marijuana: 2 people, 4.55%
  7. Fluoxetine: 2 people, 4.55%
  8. Naloxone: 2 people, 4.55%
  9. Hydroxyzine: 2 people, 4.55%
  10. Benadryl: 2 people, 4.55%

Common side effects people have besides Anhedonia *:

  1. Feeling Abnormal: 17 people, 38.64%
  2. Apathy: 15 people, 34.09%
  3. Weight Increased: 13 people, 29.55%
  4. Depression: 12 people, 27.27%
  5. Stress And Anxiety: 11 people, 25.00%
  6. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 10 people, 22.73%
  7. Suicidal Ideation: 10 people, 22.73%
  8. Thinking Abnormal: 8 people, 18.18%
  9. Erection Problems: 7 people, 15.91%
  10. Insomnia (sleeplessness): 6 people, 13.64%

Common conditions people have *:

  1. Bipolar Disorder (mood disorder): 9 people, 20.45%
  2. Psychotic Disorder: 4 people, 9.09%
  3. Depression: 4 people, 9.09%
  4. Sleep Disorder: 3 people, 6.82%
  5. Stress And Anxiety: 2 people, 4.55%
  6. Alcoholism (problems with alcohol): 2 people, 4.55%
  7. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 2 people, 4.55%
  8. Delusion (a false belief or opinion): 2 people, 4.55%
  9. Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 2 people, 4.55%
  10. Movement - Uncontrolled Or Slow: 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Invega sustenna and have Anhedonia?

Check whether Anhedonia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Invega sustenna:

Anhedonia treatments and more:

COVID vaccines that are related to Anhedonia:

How severe was Anhedonia and when was it recovered:

Expand to all the drugs that have ingredients of paliperidone palmitate:

Common drugs associated with Anhedonia:

All the drugs that are associated with Anhedonia:

Common conditions associated with Anhedonia:

All the conditions that are associated with Anhedonia:

How the study uses the data?

The study uses data from the FDA. It is based on paliperidone palmitate (the active ingredients of Invega sustenna) and Invega sustenna (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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