Isosorbide mononitrate and Aortic dilatation - a phase IV clinical study of FDA data


Aortic dilatation is found among people who take Isosorbide mononitrate, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Isosorbide mononitrate and have Aortic dilatation. It is created by eHealthMe based on reports of 23,163 people who have side effects when taking Isosorbide mononitrate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 14, 2022

23,163 people reported to have side effects when taking Isosorbide mononitrate.
Among them, 6 people (0.03%) have Aortic dilatation.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 22,094 Isosorbide mononitrate users for its effectiveness, alternative drugs and more.

What is Aortic dilatation?

Aortic dilatation is found to be associated with 665 drugs and 364 conditions by eHealthMe.

Number of Isosorbide mononitrate and Aortic dilatation reports submitted per year:

Could Isosorbide mononitrate cause Aortic dilatation?

Time on Isosorbide mononitrate when people have Aortic dilatation *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Aortic dilatation when taking Isosorbide mononitrate *:

  • female: 83.33 %
  • male: 16.67 %

Age of people who have Aortic dilatation when taking Isosorbide mononitrate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Isosorbide mononitrate *:

  1. Irbesartan: 2 people, 33.33%
  2. Hydrochlorothiazide: 2 people, 33.33%
  3. Aspirin: 2 people, 33.33%
  4. Acetylsalicylate Lysine: 2 people, 33.33%
  5. Pantoprazole: 1 person, 16.67%
  6. Omeprazole: 1 person, 16.67%
  7. Metformin Hydrochloride: 1 person, 16.67%
  8. Irbesartan Hydrochlorothiazide: 1 person, 16.67%
  9. Fluoxetine Hydrochloride: 1 person, 16.67%
  10. Felodipine: 1 person, 16.67%

Common side effects people have besides Aortic dilatation *:

  1. Chest Pain: 3 people, 50.00%
  2. Dilatation Ventricular: 3 people, 50.00%
  3. Aortic Valve Disease: 3 people, 50.00%
  4. Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 2 people, 33.33%
  5. Ventricular Hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do): 2 people, 33.33%
  6. Breathing Difficulty: 2 people, 33.33%
  7. Hypotension (abnormally low blood pressure): 2 people, 33.33%
  8. Bradycardia (abnormally slow heart action): 2 people, 33.33%
  9. Blood Sodium Decreased: 2 people, 33.33%
  10. Normochromic Normocytic Anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits): 2 people, 33.33%

Common conditions people have *:

  1. Diabetes: 2 people, 33.33%
  2. Type 2 Diabetes: 1 person, 16.67%
  3. Platelet Aggregation Abnormal: 1 person, 16.67%
  4. Lipids Abnormal: 1 person, 16.67%
  5. Electrocardiogram Qt Prolonged: 1 person, 16.67%
  6. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 16.67%
  7. Breast Cancer: 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Isosorbide mononitrate and have Aortic dilatation?

Check whether Aortic dilatation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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Browse all side effects of Isosorbide mononitrate:

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Aortic dilatation treatments and more:

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Common drugs associated with Aortic dilatation:

All the drugs that are associated with Aortic dilatation:

Common conditions associated with Aortic dilatation:

All the conditions that are associated with Aortic dilatation:

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide mononitrate (the active ingredients of Isosorbide mononitrate) and Isosorbide mononitrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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