Isosorbide mononitrate and Muscle function loss - a phase IV clinical study of FDA data


Muscle function loss is found among people who take Isosorbide mononitrate, especially for people who are male, 60+ old.

The phase IV clinical study analyzes which people take Isosorbide mononitrate and have Muscle function loss. It is created by eHealthMe based on reports of 23,163 people who have side effects when taking Isosorbide mononitrate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

23,163 people reported to have side effects when taking Isosorbide mononitrate.
Among them, 11 people (0.05%) have Muscle function loss.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 23,547 Isosorbide mononitrate users for its effectiveness, alternative drugs and more.

What is Muscle function loss?

Muscle function loss is found to be associated with 1,964 drugs and 1,398 conditions by eHealthMe.

Number of Isosorbide mononitrate and Muscle function loss reports submitted per year:

Could Isosorbide mononitrate cause Muscle function loss?

Gender of people who have Muscle function loss when taking Isosorbide mononitrate *:

  • female: 50 %
  • male: 50 %

Age of people who have Muscle function loss when taking Isosorbide mononitrate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 12.5 %
  • 60+: 87.5 %

Common drugs people take besides Isosorbide mononitrate *:

  1. Furosemide: 4 people, 36.36%
  2. Vitamins: 2 people, 18.18%
  3. Ubidecarenone: 2 people, 18.18%
  4. Sinemet: 2 people, 18.18%
  5. Aspirin: 2 people, 18.18%
  6. Rivastigmine: 2 people, 18.18%
  7. Bisoprolol Fumarate: 2 people, 18.18%
  8. Ramipril: 2 people, 18.18%
  9. Phosphatidyl Serine: 2 people, 18.18%
  10. Omega-3 Marine Triglycerides: 2 people, 18.18%

Common side effects people have besides Muscle function loss *:

  1. Drug Ineffective: 3 people, 27.27%
  2. Drowsiness: 3 people, 27.27%
  3. Rashes (redness): 3 people, 27.27%
  4. Hemiplegia (paralysis of one side of the body): 2 people, 18.18%
  5. Breathing Difficulty: 2 people, 18.18%
  6. Hypersensitivity: 2 people, 18.18%
  7. Dizziness: 2 people, 18.18%
  8. Neurological Eyelid Disorder (disease of eyelid due to nervous system): 2 people, 18.18%
  9. Confusional State: 2 people, 18.18%
  10. Oesophageal Hypomotility (low movement of oesophagus): 2 people, 18.18%

Common conditions people have *:

  1. Parkinson's Disease: 2 people, 18.18%
  2. Urinary Tract Infection: 1 person, 9.09%
  3. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 9.09%
  4. Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 9.09%
  5. Psoriasis (immune-mediated disease that affects the skin): 1 person, 9.09%
  6. Lupus Myocarditis (a chronic inflammatory autoimmune disorder that may affect heart muscle): 1 person, 9.09%
  7. Left Ventricular Failure (left ventricle fails to contract forcefully): 1 person, 9.09%
  8. Hypertriglyceridaemia (excess of triglycerides in the blood): 1 person, 9.09%
  9. High Blood Cholesterol: 1 person, 9.09%
  10. Hepatitis C: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Isosorbide mononitrate and have Muscle function loss?

Check whether Muscle function loss is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Muscle function loss and when was it recovered:

Expand to all the drugs that have ingredients of isosorbide mononitrate:

Alternative drugs to, pros and cons of Isosorbide mononitrate:

Common Isosorbide mononitrate side effects:

Browse all side effects of Isosorbide mononitrate:

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Muscle function loss treatments and more:

COVID vaccines that are related to Muscle function loss:

Common drugs associated with Muscle function loss:

All the drugs that are associated with Muscle function loss:

Common conditions associated with Muscle function loss:

All the conditions that are associated with Muscle function loss:

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide mononitrate (the active ingredients of Isosorbide mononitrate) and Isosorbide mononitrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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