Keppra and Ankylosing spondylitis - a phase IV clinical study of FDA data

Summary:

Ankylosing spondylitis is found among people who take Keppra, especially for people who are male, 40-49 old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Keppra and have Ankylosing spondylitis. It is created by eHealthMe based on reports of 63,513 people who have side effects when taking Keppra from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Dec, 08, 2022

63,513 people reported to have side effects when taking Keppra.
Among them, 13 people (0.02%) have Ankylosing spondylitis.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 66,560 Keppra users for its effectiveness, alternative drugs and more.

What is Ankylosing spondylitis?

Ankylosing spondylitis (type of arthritis affecting the spine) is found to be associated with 1,394 drugs and 866 conditions by eHealthMe.

Number of Keppra and Ankylosing spondylitis reports submitted per year:

Could Keppra cause Ankylosing spondylitis?

Time on Keppra when people have Ankylosing spondylitis *:

Gender of people who have Ankylosing spondylitis when taking Keppra *:

female: 23.08 %
male: 76.92 %

Age of people who have Ankylosing spondylitis when taking Keppra *:

Common drugs people take besides Keppra *:

Common side effects people have besides Ankylosing spondylitis *:

Fall: 9 people, 69.23%
Fatigue (feeling of tiredness): 9 people, 69.23%
Spinal Osteoarthritis (joint cartilage loss in spine): 9 people, 69.23%
Depression: 9 people, 69.23%
Confusional State: 8 people, 61.54%
Dizziness: 7 people, 53.85%
Tremor (trembling or shaking movements in one or more parts of your body): 7 people, 53.85%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 53.85%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 7 people, 53.85%
High Blood Pressure: 7 people, 53.85%

Common conditions people have *:

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 46.15%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 46.15%
Pulmonary Congestion (congestion in the lungs): 2 people, 15.38%
Pain: 2 people, 15.38%
Nausea And Vomiting: 2 people, 15.38%
Nausea (feeling of having an urge to vomit): 2 people, 15.38%
Insomnia (sleeplessness): 2 people, 15.38%
High Blood Pressure: 2 people, 15.38%
Headache (pain in head): 2 people, 15.38%
Endocarditis Bacterial (an inflammation of the inner layer of the heart by bacterial infection): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Keppra and have Ankylosing spondylitis?

Check whether Ankylosing spondylitis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
Hung YM, Cheng CC, Wann SR, Lin SL, "Ankylosing spondylitis associated with pulmonary arterial hypertension", Internal Medicine, 2016 Jan .
Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .

Related studies

How severe was Ankylosing spondylitis and when was it recovered:

Ankylosing spondylitis in Keppra

Expand to all the drugs that have ingredients of levetiracetam:

Ankylosing spondylitis and drugs with ingredients of levetiracetam (20 reports)

Alternative drugs to, pros and cons of Keppra:

Keppra (66,560 reports)

Common Keppra side effects:

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6,563 reports
Fatigue (feeling of tiredness): 3,947 reports
Drug ineffective: 3,428 reports
Drowsiness: 2,702 reports
Headache (pain in head): 2,524 reports
Dizziness: 2,508 reports
Weakness: 2,353 reports

Browse all side effects of Keppra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Ankylosing spondylitis treatments and more:

Ankylosing spondylitis (105,477 reports)

COVID vaccines that are related to Ankylosing spondylitis:

Common drugs associated with Ankylosing spondylitis:

All the drugs that are associated with Ankylosing spondylitis:

Ankylosing spondylitis (1,394 drugs)

Common conditions associated with Ankylosing spondylitis:

Rheumatoid arthritis: 1,115 reports
Pain: 647 reports
Crohn's disease: 539 reports
High blood pressure: 504 reports

All the conditions that are associated with Ankylosing spondylitis:

Ankylosing spondylitis (866 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levetiracetam (the active ingredients of Keppra) and Keppra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.