Keppra and Ankylosing spondylitis - a phase IV clinical study of FDA data


Ankylosing spondylitis is found among people who take Keppra, especially for people who are male, 40-49 old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Keppra and have Ankylosing spondylitis. It is created by eHealthMe based on reports of 63,513 people who have side effects when taking Keppra from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Dec, 08, 2022

63,513 people reported to have side effects when taking Keppra.
Among them, 13 people (0.02%) have Ankylosing spondylitis.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 66,560 Keppra users for its effectiveness, alternative drugs and more.

What is Ankylosing spondylitis?

Ankylosing spondylitis (type of arthritis affecting the spine) is found to be associated with 1,394 drugs and 866 conditions by eHealthMe.

Number of Keppra and Ankylosing spondylitis reports submitted per year:

Could Keppra cause Ankylosing spondylitis?

Time on Keppra when people have Ankylosing spondylitis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 14.29 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 85.71 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Ankylosing spondylitis when taking Keppra *:

  • female: 23.08 %
  • male: 76.92 %

Age of people who have Ankylosing spondylitis when taking Keppra *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 50 %
  • 50-59: 25 %
  • 60+: 25 %

Common drugs people take besides Keppra *:

  1. Xyrem: 6 people, 46.15%
  2. Toviaz: 6 people, 46.15%
  3. Codeine: 4 people, 30.77%
  4. Nuedexta: 4 people, 30.77%
  5. Humira: 3 people, 23.08%
  6. Microzide: 2 people, 15.38%
  7. Lamictal: 2 people, 15.38%
  8. Morphine: 2 people, 15.38%
  9. Miralax: 2 people, 15.38%
  10. Zonegran: 2 people, 15.38%

Common side effects people have besides Ankylosing spondylitis *:

  1. Fall: 9 people, 69.23%
  2. Fatigue (feeling of tiredness): 9 people, 69.23%
  3. Spinal Osteoarthritis (joint cartilage loss in spine): 9 people, 69.23%
  4. Depression: 9 people, 69.23%
  5. Confusional State: 8 people, 61.54%
  6. Dizziness: 7 people, 53.85%
  7. Tremor (trembling or shaking movements in one or more parts of your body): 7 people, 53.85%
  8. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 53.85%
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 7 people, 53.85%
  10. High Blood Pressure: 7 people, 53.85%

Common conditions people have *:

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 46.15%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 46.15%
  3. Pulmonary Congestion (congestion in the lungs): 2 people, 15.38%
  4. Pain: 2 people, 15.38%
  5. Nausea And Vomiting: 2 people, 15.38%
  6. Nausea (feeling of having an urge to vomit): 2 people, 15.38%
  7. Insomnia (sleeplessness): 2 people, 15.38%
  8. High Blood Pressure: 2 people, 15.38%
  9. Headache (pain in head): 2 people, 15.38%
  10. Endocarditis Bacterial (an inflammation of the inner layer of the heart by bacterial infection): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Keppra and have Ankylosing spondylitis?

Check whether Ankylosing spondylitis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Ankylosing spondylitis and when was it recovered:

Expand to all the drugs that have ingredients of levetiracetam:

Alternative drugs to, pros and cons of Keppra:

Common Keppra side effects:

Browse all side effects of Keppra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Ankylosing spondylitis treatments and more:

COVID vaccines that are related to Ankylosing spondylitis:

Common drugs associated with Ankylosing spondylitis:

All the drugs that are associated with Ankylosing spondylitis:

Common conditions associated with Ankylosing spondylitis:

All the conditions that are associated with Ankylosing spondylitis:

How the study uses the data?

The study uses data from the FDA. It is based on levetiracetam (the active ingredients of Keppra) and Keppra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: