Lamictal and Restless leg syndrome - a phase IV clinical study of FDA data

• Lamictal (74,513 reports)

• Abasia (inability to walk): 201 reports
• Abdominal discomfort: 491 reports
• Abdominal distension: 309 reports
• Abdominal pain: 736 reports
• Abdominal pain upper: 675 reports
• Abnormal behavior: 724 reports
• Abnormal dreams: 287 reports
• Abortion induced (medically referred abortion): 153 reports
• Abortion spontaneous (naturally occurring miscarriage): 502 reports
• Accidental overdose (therapeutic agent): 205 reports
• Acne (skin problems that cause pimples): 258 reports
• Activities of daily living impaired: 207 reports
• Acute kidney failure: 373 reports
• Adverse drug reaction: 392 reports
• Adverse event: 449 reports
• Affective disorder (mental disorder): 147 reports
• Affect lability (emotional incontinence): 113 reports
• Aggression: 866 reports
• Agitation (state of anxiety or nervous excitement): 1,401 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 402 reports
• Akathisia (a movement disorder characterized by a feeling of inner restlessness): 183 reports
• Alanine aminotransferase increased: 575 reports
• Alcoholism (problems with alcohol): 162 reports
• Altered state of consciousness (altered state of mind): 260 reports
• Anaemia (lack of blood): 572 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 202 reports
• Anger: 633 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 111 reports
• Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 213 reports
• Apathy: 159 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 870 reports
• Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 344 reports
• Arrhythmias (irregular heartbeat): 539 reports
• Arthritis (form of joint disorder that involves inflammation of one or more joints): 233 reports
• Arthropathy: 124 reports
• Aspartate aminotransferase increased: 513 reports
• Asthma: 262 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 156 reports
• Atrial septal defect (an abnormal opening between the left and right atria of the heart): 148 reports
• Aura: 185 reports
• Back pain: 874 reports
• Balance disorder: 905 reports
• Bipolar disorder (mood disorder): 572 reports
• Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode): 155 reports
• Birth control: 300 reports
• Blindness: 232 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 682 reports
• Blood alkaline phosphatase increased: 231 reports
• Blood bilirubin increased: 149 reports
• Blood creatine phosphokinase increased: 301 reports
• Blood creatinine increased: 220 reports
• Blood glucose decreased: 107 reports
• Blood glucose increased: 328 reports
• Blood lactate dehydrogenase increased: 265 reports
• Blood potassium decreased: 123 reports
• Blood sodium decreased: 121 reports
• Body temperature increased: 123 reports
• Bone disorder: 118 reports
• Bone pain: 184 reports
• Bradycardia (abnormally slow heart action): 177 reports
• Breast cancer: 102 reports
• Breathing difficulty: 1,561 reports
• Breathing - slowed or stopped: 104 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 322 reports
• Burning sensation: 322 reports
• Cardiac arrest: 243 reports
• Cardiac disorder: 166 reports
• Cardiac failure congestive: 130 reports
• Cataract (clouding of the lens inside the eye): 180 reports
• Cellulitis (infection under the skin): 168 reports
• Cheilitis (infection of lips): 170 reports
• Chest pain: 1,020 reports
• Chills (felling of cold): 543 reports
• Cholecystitis chronic (long lasting infection of gallbladder): 104 reports
• Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 166 reports
• Chronic kidney disease: 132 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 117 reports
• Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 481 reports
• Completed suicide (act of taking one's own life): 313 reports
• Complex partial seizures (epileptic seizure): 176 reports
• Condition: 1,002 reports
• Confusion: 529 reports
• Confusional state: 1,222 reports
• Conjunctival hyperaemia (congestion of conjunctival vessels): 187 reports
• Conjunctivitis (pink eye): 311 reports
• Consciousness - decreased: 490 reports
• Constipation: 801 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3,212 reports
• Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly): 142 reports
• Cough: 714 reports
• C-reactive protein increased: 421 reports
• Crying: 555 reports
• Death: 693 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 185 reports
• Dehydration (dryness resulting from the removal of water): 570 reports
• Delirium (wild excitement): 200 reports
• Delusion (a false belief or opinion): 191 reports
• Dementia (madness): 111 reports
• Dental caries: 125 reports
• Depressed level of consciousness: 427 reports
• Depressed mood: 369 reports
• Depression: 2,810 reports
• Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 339 reports
• Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid): 123 reports
• Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss): 159 reports
• Diabetes: 549 reports
• Diabetes mellitus inadequate control: 130 reports
• Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 141 reports
• Diarrhea: 1,505 reports
• Diplopia (double vision): 575 reports
• Disability: 187 reports
• Discomfort: 163 reports
• Disseminated intravascular coagulation (systemic activation of blood coagulation): 233 reports
• Disturbance in attention: 818 reports
• Dizziness: 3,448 reports
• Drooling (drop saliva uncontrollably from the mouth): 103 reports
• Drowsiness: 2,331 reports
• Drug abuse and dependence: 225 reports
• Drug administration error: 385 reports
• Drug dependence: 200 reports
• Drug effect decreased: 278 reports
• Drug eruption (adverse drug reaction of the skin): 761 reports
• Drug exposure during pregnancy: 1,489 reports
• Drug hypersensitivity: 945 reports
• Drug ineffective: 4,078 reports
• Drug intolerance (drug sensitivity): 269 reports
• Drug level decreased: 217 reports
• Drug level increased: 173 reports
• Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash): 322 reports
• Drug screen false positive: 107 reports
• Drug screen positive: 162 reports
• Drug toxicity: 194 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 437 reports
• Dry eyes (lack of adequate tears): 210 reports
• Dry mouth: 525 reports
• Dry skin: 300 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 539 reports
• Dysstasia (difficulty in standing): 148 reports
• Ear pain: 150 reports
• Eating disorder: 238 reports
• Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 223 reports
• Electrocardiogram qt prolonged: 175 reports
• Emotional disorder: 270 reports
• Emotional distress: 411 reports
• Encephalopathy (functioning of the brain is affected by some agent or condition): 198 reports
• Eosinophil count increased: 133 reports
• Eosinophilia (eosinophil count in the peripheral blood exceeds): 220 reports
• Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1,172 reports
• Erection problems: 240 reports
• Erythema multiforme (a type of hypersensitivity reaction): 2,456 reports
• Erythema of eyelid (redness of the eyelid): 133 reports
• Euphoric mood (excessively happy but may become angry or irritable): 133 reports
• Extrapyramidal disorder (involuntary muscle spasms in the face and neck): 174 reports
• Eye discharge: 153 reports
• Eye disorder: 200 reports
• Eye irritation: 108 reports
• Eyelid oedema (eyelids are swollen and contain excessive fluid): 110 reports
• Eye movements - uncontrollable: 107 reports
• Eye pain: 233 reports
• Eye pruritus (eye itching): 106 reports
• Eye swelling: 154 reports
• Face oedema (swelling of face): 376 reports
• Fainting (loss of consciousness and postural tone): 358 reports
• Fall: 1,955 reports
• Fatigue (feeling of tiredness): 3,421 reports
• Fear: 247 reports
• Feeling cold: 108 reports
• Feeling drunk: 122 reports
• Feeling hot: 240 reports
• Feeling jittery: 121 reports
• Fever: 3,590 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 172 reports
• Flatulence (flatus expelled through the anus): 149 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 600 reports
• Foot fracture: 124 reports
• Fungal infection: 126 reports
• Gait disturbance: 1,033 reports
• Gallbladder disorder: 130 reports
• Gallstones (stone formation by bile component): 153 reports
• Gamma-glutamyltransferase increased: 326 reports
• Gastric disorder (disease of stomach): 120 reports
• Gastric ulcer (stomach ulcer): 152 reports
• Gastritis (inflammation of stomach): 118 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 494 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 233 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 123 reports
• Generalised erythema (redness of the skin all over the body): 307 reports
• General physical health deterioration (weak health status): 340 reports
• Grand mal convulsion (a type of generalized seizure that affects the entire brain): 602 reports
• Haematocrit decreased: 128 reports
• Haemoglobin decreased: 280 reports
• Haemorrhage (bleeding): 225 reports
• Hair loss: 948 reports
• Hallucination, auditory (perceiving sounds without auditory stimulus): 247 reports
• Hallucinations (sensations that appear real but are created by your mind): 636 reports
• Hallucination, visual (seeing things that aren't there): 152 reports
• Headache (pain in head): 3,227 reports
• Head injury: 897 reports
• Hearing loss: 117 reports
• Heart attack: 272 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 476 reports
• Heart rate increased: 360 reports
• Heavy or prolong menstrual bleeding: 127 reports
• Hemiparesis (weakness on one side of the body): 111 reports
• Hepatic enzyme increased: 440 reports
• Hepatic failure (liver failure): 227 reports
• Hepatic steatosis (fatty liver disease): 140 reports
• Hepatitis (inflammation of the liver): 181 reports
• Hepatocellular injury (liver injury): 167 reports
• Hepatomegaly (abnormal enlargement of the liver): 131 reports
• Herpes zoster: 133 reports
• High blood cholesterol: 511 reports
• High blood pressure: 1,150 reports
• Hoarseness or changing voice: 177 reports
• Hospitalisation: 386 reports
• Hot flush (sudden feelings of heat): 250 reports
• Hyperglycemia (high blood sugar): 139 reports
• Hyperhidrosis (abnormally increased sweating): 646 reports
• Hyperlipidaemia (presence of excess lipids in the blood): 127 reports
• Hypersensitivity: 838 reports
• Hypoaesthesia (reduced sense of touch or sensation): 749 reports
• Hypoglycemia (low blood sugar): 175 reports
• Hypokalemia (low potassium): 193 reports
• Hypokinesia (decreased bodily movement): 102 reports
• Hypomania (a mild form of mania, marked by elation and hyperactivity): 206 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 356 reports
• Hypophagia (reduced food intake): 133 reports
• Hypotension (abnormally low blood pressure): 786 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 205 reports
• Hypotonia (low muscle tone): 109 reports
• Ill-defined disorder: 439 reports
• Impaired driving ability: 144 reports
• Impaired healing: 119 reports
• Impaired work ability: 171 reports
• Incontinence (lack of moderation or self-control): 113 reports
• Indigestion: 320 reports
• Infarction (obstruction of the blood supply to an organ or region of tissue): 163 reports
• Infection: 339 reports
• Inflammation: 228 reports
• Influenza like illness: 465 reports
• Injection site erythema (redness at injection site): 133 reports
• Injection site pain: 334 reports
• Injury: 440 reports
• Insomnia (sleeplessness): 2,361 reports
• Intentional overdose: 415 reports
• Intentional self-injury: 241 reports
• Interstitial lung disease: 123 reports
• Intervertebral disc protrusion (spinal disc protrusion): 149 reports
• Intestinal obstruction: 139 reports
• Irritability: 900 reports
• Irritable bowel syndrome: 106 reports
• Itching: 1,987 reports
• Jaundice - yellow skin (a yellowish pigmentation of the skin): 195 reports
• Joint injury: 112 reports
• Joint pain: 1,159 reports
• Joint swelling: 249 reports
• Kidney stones: 219 reports
• Lacrimation increased: 105 reports
• Leukocytosis (increased white blood cells): 112 reports
• Leukopenia (less number of white blood cells in blood): 298 reports
• Libido decreased (loss of interest in sex): 115 reports
• Lip erosion (peeling off of lip): 253 reports
• Lip swelling: 262 reports
• Live birth: 271 reports
• Liver disorder (liver diseases): 291 reports
• Local swelling (swelling at the site of some application of substance or injury): 144 reports
• Logorrhea: 120 reports
• Loss of consciousness: 1,052 reports
• Lower limb fracture: 101 reports
• Low tissue oxygen: 128 reports
• Lung disorder (lung disease): 134 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 993 reports
• Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 102 reports
• Malaise (a feeling of general discomfort or uneasiness): 1,927 reports
• Mania (a state of abnormally elevated or irritable mood): 871 reports
• Maternal drugs affecting foetus (chemical affecting the baby before birth taken by mother): 221 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 375 reports
• Memory loss: 2,070 reports
• Menstruation irregular: 117 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 488 reports
• Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 313 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 171 reports
• Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night): 106 reports
• Migraine (headache): 646 reports
• Mobility decreased (ability to move is reduced): 151 reports
• Mood swings (an extreme or rapid change in mood): 724 reports
• Mouth ulcers: 412 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 178 reports
• Movement - uncontrolled or slow: 205 reports
• Movement - uncoordinated: 342 reports
• Mucosal erosion (peeling off of mucous membrane): 103 reports
• Mucous membrane disorder (disease of mucous membrane): 142 reports
• Multi-organ failure (multisystem organ failure): 180 reports
• Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 132 reports
• Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 194 reports
• Muscle aches (muscle pain): 722 reports
• Muscle function loss: 102 reports
• Muscle rigidity (muscle stiffness): 106 reports
• Muscle spasms (muscle contraction): 694 reports
• Muscle tightness: 129 reports
• Muscle twitching: 328 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 172 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 405 reports
• Mydriasis (a dilation of the pupil): 105 reports
• Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 142 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 178 reports
• Nasopharyngitis (inflammation of the nasopharynx): 475 reports
• Nausea (feeling of having an urge to vomit): 3,548 reports
• Nausea and vomiting: 2,241 reports
• Neck pain: 377 reports
• Nervousness: 408 reports
• Nervous system disorder (a general class of medical conditions affecting the nervous system): 146 reports
• Neuralgia (pain in one or more nerves): 102 reports
• Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 159 reports
• Neuropathy peripheral (surface nerve damage): 386 reports
• Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 122 reports
• Nightmares (unpleasant dreams): 315 reports
• Night sweats (sweating in night): 179 reports
• Nosebleed (bleeding from nose): 247 reports
• Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 227 reports
• Ocular hyperaemia (an abnormally large amount of blood in eye): 335 reports
• Oedema (fluid collection in tissue): 357 reports
• Oedema peripheral (superficial swelling): 627 reports
• Oral disorder (mouth disease): 105 reports
• Oral mucosa erosion (erosion of mouth mucous membrane): 249 reports
• Oral pain: 242 reports
• Oropharyngeal pain: 500 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 252 reports
• Osteopenia (a condition where bone mineral density is lower than normal): 101 reports
• Osteoporosis (bones weak and more likely to break): 170 reports
• Overdose: 1,266 reports
• Oxygen saturation decreased: 140 reports
• Pain: 1,942 reports
• Pain in extremity: 842 reports
• Paleness (unusual lightness of skin colour): 142 reports
• Pancreatitis (inflammation of pancreas): 315 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 231 reports
• Panic disorder: 485 reports
• Papule: 104 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 759 reports
• Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 260 reports
• Parkinson's disease: 181 reports
• Partial seizures (seizures which affect only a part of the brain at onset): 217 reports
• Peripheral swelling: 218 reports
• Personality change: 136 reports
• Petit mal epilepsy (absence seizure): 366 reports
• Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal): 149 reports
• Pharyngitis (inflammation of the pharynx, causing a sore throat): 106 reports
• Pharyngolaryngeal pain: 144 reports
• Photophobia (extreme sensitivity to light): 221 reports
• Photosensitivity reaction: 145 reports
• Pigmentation disorder (disturbances of human skin colour): 103 reports
• Pleural effusion (water on the lungs): 195 reports
• Pneumonia: 774 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 161 reports
• Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 179 reports
• Poor quality sleep: 173 reports
• Post-traumatic stress disorder: 103 reports
• Pre-existing condition improved: 196 reports
• Premature baby: 312 reports
• Premature labor: 134 reports
• Prescribed overdose: 154 reports
• Pruritus generalised (generalized itching): 178 reports
• Psoriasis (immune-mediated disease that affects the skin): 176 reports
• Psychomotor hyperactivity (feelings of extreme restlessness): 214 reports
• Psychotic disorder: 451 reports
• Pulmonary embolism (blockage of the main artery of the lung): 314 reports
• Purpura (purplish discoloration of the skin): 123 reports
• Rash erythematous (redness of the skin): 546 reports
• Rashes (redness): 7,465 reports
• Rash macular (small, flat red spots): 330 reports
• Rash maculo-papular (red area on the skin that is covered with small confluent bumps): 576 reports
• Rash papular (redness with papule): 313 reports
• Rash pruritic (redness with itching): 433 reports
• Rash pustular (redness with pustules): 116 reports
• Rash vesicular (rash with a small bubble): 116 reports
• Rectal haemorrhage (bleeding from anus): 129 reports
• Red blood cell count decreased: 130 reports
• Renal disorder (kidney disease): 158 reports
• Renal failure acute (rapid kidney dysfunction): 222 reports
• Renal impairment (severely reduced kidney function): 218 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 239 reports
• Respiratory disorder (respiratory disease): 148 reports
• Respiratory distress (difficulty in breathing): 171 reports
• Restless leg syndrome (a powerful urge to move your legs): 213 reports
• Retching (strong involuntary effort to vomit): 158 reports
• Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 261 reports
• Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 146 reports
• Rib fracture: 137 reports
• Road traffic accident: 392 reports
• Salivary hypersecretion (excess saliva secretion): 125 reports
• Scab (a hard coating on the skin formed during the wound healing): 163 reports
• Scar: 207 reports
• Sedation: 431 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2,326 reports
• Sensory disturbance (sense disturbance): 106 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 311 reports
• Sinusitis (inflammation of sinus): 406 reports
• Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 103 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 292 reports
• Skin burning sensation: 127 reports
• Skin discoloration: 301 reports
• Skin discoloration - bluish (bluish colour of skin): 107 reports
• Skin disorder (skin disease): 445 reports
• Skin erosion (a discontinuity of the skin): 124 reports
• Skin exfoliation (removal of the oldest dead skin cells): 518 reports
• Skin ulcer: 120 reports
• Sleep apnea syndrome: 284 reports
• Sleep disorder: 447 reports
• Sleep walking (walking during sleep): 114 reports
• Speech disorder: 578 reports
• Speech impairment (adult) (inability to speak (adult)): 741 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 196 reports
• Staring (a prolonged gaze or fixed look): 113 reports
• Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 400 reports
• Stomatitis (inflammation of mucous membrane of mouth): 431 reports
• Stress and anxiety: 3,140 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 361 reports
• Suicidal behavior: 104 reports
• Suicidal ideation: 1,615 reports
• Suicide attempt: 1,025 reports
• Surgery: 190 reports
• Swallowing difficulty: 719 reports
• Swelling: 347 reports
• Swelling face: 375 reports
• Swollen tongue (swelling of tongue): 270 reports
• Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 141 reports
• Tachyphrenia (abnormally rapid mental activity): 113 reports
• Tardive dyskinesia (a disorder that involves involuntary movements): 310 reports
• Taste - impaired: 324 reports
• Tenderness (pain or discomfort when an affected area is touched): 101 reports
• The flu (the flu is caused by an influenza virus): 318 reports
• Therapeutic response decreased (less preventive response): 215 reports
• Therapeutic response unexpected: 382 reports
• Thirst: 127 reports
• Throat tightness: 134 reports
• Thrombocytopenia (decrease of platelets in blood): 814 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 137 reports
• Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 117 reports
• Tinnitus (a ringing in the ears): 273 reports
• Tongue disorder (disease of tongue): 111 reports
• Tooth disorder (tooth disease): 113 reports
• Toxic skin eruption (skin breakdown due to toxic substance): 285 reports
• Transaminases increased: 122 reports
• Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 149 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 1,915 reports
• Type 2 diabetes: 401 reports
• Unintended pregnancy (unwanted pregnancies as well as those that are mistimed): 103 reports
• Upper limb fracture: 155 reports
• Upper respiratory tract infection: 261 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 224 reports
• Urinary retention (the inability to completely or partially empty the bladder): 238 reports
• Urinary tract infection: 755 reports
• Urination - painful: 169 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 813 reports
• Vaginal bleeding: 182 reports
• Vaginal bleeding between periods: 200 reports
• Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital)): 130 reports
• Viral infection: 216 reports
• Vision blurred: 1,096 reports
• Visual acuity reduced (reduced clearness of vision): 274 reports
• Visual disturbance: 154 reports
• Visual impairment: 529 reports
• Weakness: 1,922 reports
• Weight decreased: 1,211 reports
• Weight increased: 1,728 reports
• Weight loss: 264 reports
• Wheezing (a high-pitched whistling sound made while you breath): 172 reports
• White blood cell count decreased: 482 reports
• White blood cell count increased: 365 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 368 reports

• Restless leg syndrome (41,962 reports)

• Abilify: 423 reports
• Acetaminophen: 153 reports
• Acetylsalicylic acid: 221 reports
• Aciphex: 105 reports
• Actemra: 124 reports
• Actonel: 106 reports
• Adderall: 252 reports
• Advair diskus 100/50: 132 reports
• Advair hfa: 109 reports
• Advil: 120 reports
• Albuterol: 340 reports
• Albuterol sulfate: 102 reports
• Alendronate sodium: 277 reports
• Aleve: 108 reports
• Allegra: 182 reports
• Allopurinol: 205 reports
• Alprazolam: 219 reports
• Ambien: 476 reports
• Amlodipine: 283 reports
• Amoxicillin: 151 reports
• Ampyra: 148 reports
• Aredia: 183 reports
• Aripiprazole: 157 reports
• Aspirin: 900 reports
• Atenolol: 281 reports
• Ativan: 327 reports
• Atrovent: 113 reports
• Avonex: 268 reports
• Baclofen: 246 reports
• Benadryl: 280 reports
• Calcium: 263 reports
• Carvedilol: 127 reports
• Celebrex: 340 reports
• Celexa: 214 reports
• Chantix: 180 reports
• Claritin: 178 reports
• Clonazepam: 679 reports
• Clonidine: 124 reports
• Clopra: 842 reports
• Codeine: 121 reports
• Colace: 159 reports
• Coumadin: 359 reports
• Cozaar: 119 reports
• Crestor: 321 reports
• Crysvita: 169 reports
• Cymbalta: 754 reports
• Decadron: 101 reports
• Depakote: 154 reports
• Diazepam: 307 reports
• Dilaudid: 103 reports
• Diovan: 171 reports
• Diphen: 149 reports
• Doxycycline: 143 reports
• Duragesic: 152 reports
• Duragesic-100: 104 reports
• Effexor: 485 reports
• Effexor xr: 155 reports
• Elavil: 102 reports
• Eliquis: 112 reports
• Enbrel: 301 reports
• Escitalopram: 198 reports
• Fentanyl: 182 reports
• Fish oil: 247 reports
• Flexeril: 194 reports
• Flomax: 111 reports
• Flonase: 217 reports
• Fluoxetine: 355 reports
• Folic acid: 153 reports
• Forteo: 217 reports
• Fosamax: 892 reports
• Furosemide: 423 reports
• Gabapentin: 882 reports
• Geodon: 116 reports
• Gilenya: 266 reports
• Humalog: 131 reports
• Humira: 424 reports
• Hydramine: 149 reports
• Hydrochlorothiazide: 383 reports
• Hydrocodone bitartrate and acetaminophen: 111 reports
• Ibu: 428 reports
• Ibuprofen: 427 reports
• Klonopin: 384 reports
• Klor-con: 106 reports
• Lamictal: 213 reports
• Lamotrigine: 143 reports
• Lansoprazole: 137 reports
• Lantus: 171 reports
• Lasix: 450 reports
• Latuda: 145 reports
• Levaquin: 166 reports
• Levothyroxine sodium: 214 reports
• Lexapro: 387 reports
• Lipitor: 574 reports
• Lisinopril: 571 reports
• Lopurin: 205 reports
• Loratadine: 135 reports
• Loraz: 497 reports
• Lorazepam: 446 reports
• Lortab: 196 reports
• Losartan: 203 reports
• Lunesta: 105 reports
• Lyrica: 829 reports
• Magnesium: 271 reports
• Melatonin: 223 reports
• Meloxicam: 166 reports
• Metformin: 510 reports
• Methotrexate: 384 reports
• Metoclopramide: 840 reports
• Metoclopramide hydrochloride: 178 reports
• Metoprolol tartrate: 150 reports
• Miralax: 125 reports
• Mirapex: 495 reports
• Mirtazapine: 548 reports
• Modafinil: 143 reports
• Morphine: 310 reports
• Motrin: 102 reports
• Multivitamin: 177 reports
• Naproxen: 101 reports
• Nasonex: 113 reports
• Neupro: 213 reports
• Neurontin: 477 reports
• Nexium: 458 reports
• Norco: 147 reports
• Norvasc: 224 reports
• Nuvigil: 158 reports
• Olanzapine: 144 reports
• Omeprazole: 712 reports
• Ondansetron: 145 reports
• Opsumit: 121 reports
• Oxycodone: 253 reports
• Oxycontin: 286 reports
• Pantoprazole: 299 reports
• Paracetamol: 137 reports
• Paroxetine: 220 reports
• Paxil: 267 reports
• Pepcid: 139 reports
• Percocet: 311 reports
• Phenergan: 126 reports
• Plaquenil: 146 reports
• Plavix: 210 reports
• Potassium: 113 reports
• Prednisone: 595 reports
• Pregabalin: 133 reports
• Premarin: 207 reports
• Prevacid: 214 reports
• Prilosec: 387 reports
• Profen: 427 reports
• Promethazine: 108 reports
• Protonix: 272 reports
• Provigil: 134 reports
• Prozac: 329 reports
• Pulmicort: 119 reports
• Quetiapine fumarate: 115 reports
• Ramipril: 164 reports
• Ranitidine: 183 reports
• Reglan: 362 reports
• Remicade: 108 reports
• Requip: 803 reports
• Restoril: 102 reports
• Revlimid: 175 reports
• Risperdal: 212 reports
• Ritalin: 122 reports
• Saphris: 108 reports
• Seroquel: 678 reports
• Sertraline: 425 reports
• Simvastatin: 356 reports
• Sinemet: 170 reports
• Singulair: 327 reports
• Spiriva: 232 reports
• Spironolactone: 182 reports
• Suboxone: 117 reports
• Symbicort: 158 reports
• Synthroid: 574 reports
• Tecfidera: 114 reports
• Temaz: 141 reports
• Temazepam: 141 reports
• Topamax: 182 reports
• Topiramate: 102 reports
• Toprol-xl: 115 reports
• Tramadol: 591 reports
• Tylenol: 417 reports
• Tysabri: 196 reports
• Ultram: 125 reports
• Valium: 197 reports
• Vicodin: 248 reports
• Vioxx: 314 reports
• Vitamin b12: 285 reports
• Vitamin c: 186 reports
• Vitamin d: 515 reports
• Vitamin d3: 249 reports
• Vitamins: 252 reports
• Vivitrol: 111 reports
• Wellbutrin: 403 reports
• Xanax: 478 reports
• Xeljanz: 103 reports
• Xtandi: 198 reports
• Xyrem: 748 reports
• Zantac: 208 reports
• Zetia: 121 reports
• Zide: 384 reports
• Zocor: 235 reports
• Zofran: 237 reports
• Zoloft: 437 reports
• Zolpidem: 230 reports
• Zometa: 268 reports
• Zopiclone: 193 reports
• Zyprexa: 158 reports
• Zyrtec: 237 reports

All the drugs that are associated with Restless leg syndrome:

• Restless leg syndrome (2,304 drugs)

• Acid reflux: 420 reports
• Acupuncture and pain: 549 reports
• Adult hypothyroidism: 240 reports
• Alternative medicine - pain relief: 907 reports
• Antidepressant therapy: 1,489 reports
• Anxiety: 707 reports
• Anxiety aggravated: 707 reports
• Anxiety and stress: 707 reports
• Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 707 reports
• Apprehension: 707 reports
• Arthritis: 222 reports
• Arthritis - rheumatoid: 661 reports
• Asthma: 305 reports
• Back pain: 234 reports
• Back pain - nonspecific: 234 reports
• Bipolar: 496 reports
• Bi-polar: 496 reports
• Bipolar 1: 108 reports
• Bipolar disorder: 496 reports
• Blood cholesterol abnormal: 618 reports
• Blood cholesterol increased: 618 reports
• Blood pressure abnormal: 187 reports
• Blood pressure - high: 701 reports
• Blood pressure increased: 701 reports
• Blood triglycerides abnormal: 618 reports
• Blood triglycerides increased: 618 reports
• Bronchial asthma: 298 reports
• Cancer - prostate: 192 reports
• Cannot sleep: 456 reports
• Can't sleep: 456 reports
• Cardiac disorder: 124 reports
• Cataplexy: 315 reports
• Cessation of smoking: 146 reports
• Chronic asthma: 298 reports
• Chronic obstructive airway disease: 108 reports
• Chronic obstructive pulmonary disease: 108 reports
• Copd: 108 reports
• Crohns: 178 reports
• Crohn's disease: 178 reports
• Crohns disease: 178 reports
• Crohn's disease aggravated: 178 reports
• Daytime sleep disorder: 660 reports
• Depression: 1,489 reports
• Depression aggravated: 1,489 reports
• Depression - major: 229 reports
• Diabetes: 254 reports
• Diabetes mellitus: 255 reports
• Diabetes mellitus management: 254 reports
• Diabetes - type 2: 150 reports
• Diabetic type 2: 150 reports
• Dm: 254 reports
• Drug dependence: 143 reports
• Dyslipidemia: 618 reports
• Dyspepsia: 140 reports
• Dyssomnia: 456 reports
• Excessive sleepiness: 400 reports
• Exercise-induced asthma: 298 reports
• Familial primary pulmonary hypertension: 257 reports
• Feeling uptight: 707 reports
• Fibromyalgia: 341 reports
• Fibromyalgia syndrome: 341 reports
• Fibromyositis: 341 reports
• Fibrositis: 341 reports
• Gastroesophageal reflux disease: 450 reports
• Gastro-oesophageal reflux disease: 420 reports
• Gastrooesophageal reflux disease: 420 reports
• Gerd: 420 reports
• Gerds: 420 reports
• Glucose test: 204 reports
• Granulomatous ileocolitis: 178 reports
• Hbp: 701 reports
• Headache: 107 reports
• Headaches: 107 reports
• Heartburn: 424 reports
• Heartburn - chronic: 450 reports
• Hepatitis c: 119 reports
• High blood cholesterol: 618 reports
• High blood cholesterol and triglycerides: 618 reports
• High blood pressure: 701 reports
• High cholesterol: 618 reports
• Htn: 701 reports
• Hypercholesterolaemia: 618 reports
• Hypercholesterolemia: 618 reports
• Hyperlipidemia: 618 reports
• Hyperlipoproteinemia: 618 reports
• Hypertension: 703 reports
• Hypertension aggravated: 703 reports
• Hypothyroid: 240 reports
• Hypothyroidism: 240 reports
• Hypothyroids: 240 reports
• Hypothyroidy: 240 reports
• Inability to sleep: 456 reports
• Indigestion: 140 reports
• Inflammatory bowel disease - crohn's disease: 178 reports
• Insomnia: 456 reports
• Insomnia concerns: 456 reports
• Insomnia exacerbated: 456 reports
• Insomnolence: 456 reports
• Jitters: 707 reports
• Joint inflammation: 222 reports
• Ldl/hdl ratio increased: 618 reports
• Lipid disorders: 618 reports
• Lipid test: 618 reports
• Lipoprotein test: 618 reports
• Lower cholesterol: 472 reports
• Low thyroid: 240 reports
• Major depression: 229 reports
• Major depressive disorder: 230 reports
• Migraine: 235 reports
• Migraines: 235 reports
• Ms: 1,014 reports
• Ms hug: 1,014 reports
• Multiple myeloma: 200 reports
• Multiple sclerosis: 1,014 reports
• Muscle spasm: 234 reports
• Muscle spasms: 234 reports
• Myofascial pain syndrome: 341 reports
• Myxedema: 246 reports
• Narcolepsy: 660 reports
• Nausea: 181 reports
• Nerve pain: 191 reports
• Neuralgia: 191 reports
• Neuropathy peripheral: 163 reports
• Niddm: 150 reports
• Nocturnal myoclonus: 1,066 reports
• Non-cardiac chest pain: 420 reports
• Osteopenia: 295 reports
• Osteoporosis: 948 reports
• Pain: 909 reports
• Pain management: 907 reports
• Pain relief: 907 reports
• Panic attack: 122 reports
• Panic attacks: 122 reports
• Panic disorder: 122 reports
• Paralysis agitans: 355 reports
• Parkinson: 115 reports
• Parkinsonism: 355 reports
• Parkinsons: 115 reports
• Parkinson's disease: 356 reports
• Parkinson's disease aggravated: 356 reports
• Periodic limb movement disorder: 1,066 reports
• Plaque psoriasis: 153 reports
• Plasma cell myeloma: 200 reports
• Plmd: 1,066 reports
• Postherpetic neuralgia: 191 reports
• Post traumatic stress disorder: 128 reports
• Post-traumatic stress disorder: 107 reports
• Primary pulmonary hypertension: 257 reports
• Prostate cancer: 192 reports
• Psoriasis: 153 reports
• Psoriasis aggravated: 153 reports
• Psoriatic arthropathy: 139 reports
• Psoriatic arthropathy aggravated: 139 reports
• Psychotic disorder: 117 reports
• Ptsd: 128 reports
• Pulmonary arterial hypertension: 257 reports
• Pulmonary hypertension: 103 reports
• Pyrosis: 420 reports
• Quit smoking: 146 reports
• Ra: 661 reports
• Reduce cholesterol: 571 reports
• Reflux: 450 reports
• Reflux esophagitis: 420 reports
• Regional enteritis: 178 reports
• Restless leg: 1,513 reports
• Restless legs: 1,450 reports
• Restless legs syndrome: 1,450 reports
• Restless leg syndrome: 1,450 reports
• Rheumatoid arthritis: 661 reports
• Rls: 1,513 reports
• Schizophrenia: 193 reports
• Sleep aid: 456 reports
• Sleep disorder: 400 reports
• Sleep disorder due to a general medical condition: 400 reports
• Sleep disorder due to general medical condition, insomnia type: 400 reports
• Sleep disorder therapy: 400 reports
• Sleeping: 456 reports
• Sleeping difficulty: 456 reports
• Sleep issues: 456 reports
• Sleeplessness: 456 reports
• Sleep - too much: 400 reports
• Smoker: 146 reports
• Smoking and smokeless tobacco: 146 reports
• Smoking cessation: 146 reports
• Smoking cessation therapy: 146 reports
• Stomach upset: 140 reports
• Stop smoking: 146 reports
• Stress: 707 reports
• Stress and anxiety: 707 reports
• Tension: 707 reports
• Thin bones: 908 reports
• Thyroid: 119 reports
• Thyroid diseases: 149 reports
• Thyroid disorder: 153 reports
• Thyroide: 149 reports
• Thyroid function test abnormal: 149 reports
• Tobacco abuse: 146 reports
• Tobacco user: 146 reports
• Type 2 diabetes: 150 reports
• Type 2 diabetes mellitus: 150 reports
• Underactive thyroid: 240 reports
• Under active thyroids: 240 reports
• Unipolar depression: 229 reports
• Wakefulness: 456 reports

All the conditions that are associated with Restless leg syndrome:

• Restless leg syndrome (1,736 conditions)

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