Leflunomide and Scratch - a phase IV clinical study of FDA data


Scratch is found among people who take Leflunomide, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Leflunomide and have Scratch. It is created by eHealthMe based on reports of 67,544 people who have side effects when taking Leflunomide from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 13, 2022

67,544 people reported to have side effects when taking Leflunomide.
Among them, 45 people (0.07%) have Scratch.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 67,901 Leflunomide users for its effectiveness, alternative drugs and more.

What is Scratch?

Scratch is found to be associated with 1,236 drugs and 695 conditions by eHealthMe.

Number of Leflunomide and Scratch reports submitted per year:

Could Leflunomide cause Scratch?

Gender of people who have Scratch when taking Leflunomide *:

  • female: 72.09 %
  • male: 27.91 %

Age of people who have Scratch when taking Leflunomide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 2.63 %
  • 40-49: 18.42 %
  • 50-59: 23.68 %
  • 60+: 55.26 %

Common drugs people take besides Leflunomide *:

  1. Humira: 19 people, 42.22%
  2. Cosentyx: 13 people, 28.89%
  3. Xeljanz: 10 people, 22.22%
  4. Stelara: 9 people, 20.00%
  5. Plaquenil: 7 people, 15.56%
  6. Calcium: 7 people, 15.56%
  7. Elavil: 6 people, 13.33%
  8. Calcipotriene And Betamethasone Dipropionate: 5 people, 11.11%
  9. Methotrexate: 5 people, 11.11%
  10. Armour Thyroid: 4 people, 8.89%

Common side effects people have besides Scratch *:

  1. Joint Pain: 25 people, 55.56%
  2. Itching: 19 people, 42.22%
  3. Fatigue (feeling of tiredness): 15 people, 33.33%
  4. Pain: 14 people, 31.11%
  5. Pain In Extremity: 14 people, 31.11%
  6. Diarrhea: 14 people, 31.11%
  7. Malaise (a feeling of general discomfort or uneasiness): 14 people, 31.11%
  8. Psoriasis (immune-mediated disease that affects the skin): 12 people, 26.67%
  9. Headache (pain in head): 10 people, 22.22%
  10. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 10 people, 22.22%

Common conditions people have *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 14 people, 31.11%
  2. Psoriasis (immune-mediated disease that affects the skin): 10 people, 22.22%
  3. Gastric Disorder (disease of stomach): 4 people, 8.89%
  4. Metastatic Carcinoid Tumor: 3 people, 6.67%
  5. Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 3 people, 6.67%
  6. Depression: 2 people, 4.44%
  7. Stress And Anxiety: 1 person, 2.22%
  8. Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 1 person, 2.22%
  9. Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 2.22%
  10. Pain: 1 person, 2.22%

* Approximation only. Some reports may have incomplete information.

Do you take Leflunomide and have Scratch?

Check whether Scratch is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Scratch and when was it recovered:

Expand to all the drugs that have ingredients of leflunomide:

Alternative drugs to, pros and cons of Leflunomide:

Common Leflunomide side effects:

Browse all side effects of Leflunomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Scratch treatments and more:

COVID vaccines that are related to Scratch:

Common drugs associated with Scratch:

All the drugs that are associated with Scratch:

Common conditions associated with Scratch:

All the conditions that are associated with Scratch:

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Leflunomide) and Leflunomide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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