Lortab and Initial insomnia - a phase IV clinical study of FDA data


Initial insomnia is found among people who take Lortab, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months.

The phase IV clinical study analyzes which people take Lortab and have Initial insomnia. It is created by eHealthMe based on reports of 29,018 people who have side effects when taking Lortab from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

29,018 people reported to have side effects when taking Lortab.
Among them, 27 people (0.09%) have Initial insomnia.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 30,751 Lortab users for its effectiveness, alternative drugs and more.

What is Initial insomnia?

Initial insomnia (feeling of inadequate or poor-quality sleep) is found to be associated with 1,181 drugs and 650 conditions by eHealthMe.

Number of Lortab and Initial insomnia reports submitted per year:

Could Lortab cause Initial insomnia?

Time on Lortab when people have Initial insomnia *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Initial insomnia when taking Lortab *:

  • female: 69.23 %
  • male: 30.77 %

Age of people who have Initial insomnia when taking Lortab *:

  • 0-1: 0.0 %
  • 2-9: 4.35 %
  • 10-19: 0.0 %
  • 20-29: 8.7 %
  • 30-39: 13.04 %
  • 40-49: 17.39 %
  • 50-59: 26.09 %
  • 60+: 30.43 %

Common drugs people take besides Lortab *:

  1. Lunesta: 8 people, 29.63%
  2. Neurontin: 7 people, 25.93%
  3. Lyrica: 4 people, 14.81%
  4. Paxil: 4 people, 14.81%
  5. Celebrex: 4 people, 14.81%
  6. Robaxin: 3 people, 11.11%
  7. Gabapentin: 3 people, 11.11%
  8. Flexeril: 3 people, 11.11%
  9. Skelaxin: 3 people, 11.11%
  10. Synthroid: 3 people, 11.11%

Common side effects people have besides Initial insomnia *:

  1. Dizziness: 9 people, 33.33%
  2. Nausea (feeling of having an urge to vomit): 8 people, 29.63%
  3. Weight Decreased: 8 people, 29.63%
  4. Chest Pain: 8 people, 29.63%
  5. Breathing Difficulty: 8 people, 29.63%
  6. Diarrhea: 6 people, 22.22%
  7. Fatigue (feeling of tiredness): 6 people, 22.22%
  8. Insomnia (sleeplessness): 5 people, 18.52%
  9. Weakness: 5 people, 18.52%
  10. Headache (pain in head): 5 people, 18.52%

Common conditions people have *:

  1. Insomnia (sleeplessness): 8 people, 29.63%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 14.81%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.41%
  4. Thyroid Diseases: 2 people, 7.41%
  5. Quit Smoking: 2 people, 7.41%
  6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 7.41%
  7. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 3.70%
  8. Abdominal Pain Upper: 1 person, 3.70%
  9. Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 3.70%
  10. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Lortab and have Initial insomnia?

Check whether Initial insomnia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Initial insomnia and when was it recovered:

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Alternative drugs to, pros and cons of Lortab:

Common Lortab side effects:

Browse all side effects of Lortab:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Initial insomnia treatments and more:

COVID vaccines that are related to Initial insomnia:

Common drugs associated with Initial insomnia:

All the drugs that are associated with Initial insomnia:

Common conditions associated with Initial insomnia:

All the conditions that are associated with Initial insomnia:

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Lortab) and Lortab (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: