Losartan and Contact lens intolerance - a phase IV clinical study of FDA data

• Losartan (146,350 reports)

• Abasia (inability to walk): 421 reports
• Abdominal discomfort: 2,157 reports
• Abdominal distension: 1,286 reports
• Abdominal pain: 2,436 reports
• Abdominal pain lower: 170 reports
• Abdominal pain upper: 2,770 reports
• Abnormal behavior: 234 reports
• Abnormal dreams: 214 reports
• Abscess (pus): 131 reports
• Accidental overdose (therapeutic agent): 119 reports
• Acidosis (build-up of carbon dioxide in the blood): 109 reports
• Acne (skin problems that cause pimples): 287 reports
• Activities of daily living impaired: 209 reports
• Acute kidney failure: 3,515 reports
• Acute myocardial infarction (acute heart attack): 580 reports
• Acute respiratory failure: 261 reports
• Acute upper airway obstruction (blockage occurs in the upper airway): 348 reports
• Adverse drug reaction: 563 reports
• Adverse event: 477 reports
• Ageusia (loss of taste functions of the tongue): 423 reports
• Aggression: 224 reports
• Agitation (state of anxiety or nervous excitement): 776 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 610 reports
• Alanine aminotransferase increased: 519 reports
• Altered state of consciousness (altered state of mind): 128 reports
• Anaemia (lack of blood): 2,606 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 361 reports
• Anger: 221 reports
• Angina unstable (chest pain due to ischemia of the heart muscle- unstable): 156 reports
• Angioedema (rapid swelling of the dermis): 524 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 413 reports
• Ankle fracture: 186 reports
• Ankylosing spondylitis (type of arthritis affecting the spine): 161 reports
• Anuria (failure of the kidneys to produce urine): 135 reports
• Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta): 110 reports
• Aphonia (inability to produce voice): 234 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 3,150 reports
• Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 309 reports
• Application site erythema (redness of the skin at application site): 146 reports
• Application site pain: 182 reports
• Application site pruritus (application site severe itching of the skin): 137 reports
• Arrhythmias (irregular heartbeat): 1,384 reports
• Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked): 236 reports
• Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery): 103 reports
• Arthritis (form of joint disorder that involves inflammation of one or more joints): 1,241 reports
• Arthropathy: 756 reports
• Ascites (accumulation of fluid in the abdominal cavity): 196 reports
• Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 135 reports
• Aspartate aminotransferase increased: 453 reports
• Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body): 143 reports
• Asthma: 1,110 reports
• Asthmatic crisis: 169 reports
• Atelectasis (partial or complete collapse of the lung): 125 reports
• Atherosclerosis (disorder of the arteries): 137 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1,753 reports
• Atrioventricular block (heart block): 152 reports
• Atrioventricular block first degree (heart block first degree): 102 reports
• Back disorder: 258 reports
• Back injury: 119 reports
• Back pain: 3,383 reports
• Bacterial infection: 210 reports
• Balance disorder: 1,376 reports
• Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills): 296 reports
• Bedridden: 167 reports
• Belching (release of gas from the digestive tract): 232 reports
• Bladder cancer: 157 reports
• Bladder disorder: 151 reports
• Bleeding disorders: 221 reports
• Bleeding into the skin: 192 reports
• Blindness: 492 reports
• Blindness unilateral: 233 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 658 reports
• Blood alkaline phosphatase increased: 221 reports
• Blood bilirubin increased: 242 reports
• Blood calcium decreased: 129 reports
• Blood creatine phosphokinase increased: 290 reports
• Blood creatinine increased: 1,216 reports
• Blood glucose decreased: 574 reports
• Blood glucose fluctuation: 196 reports
• Blood glucose increased: 2,255 reports
• Blood iron decreased: 197 reports
• Blood lactate dehydrogenase increased: 135 reports
• Blood magnesium decreased: 166 reports
• Blood potassium decreased: 578 reports
• Blood pressure fluctuation: 527 reports
• Blood pressure management: 750 reports
• Blood pressure systolic increased: 316 reports
• Blood sodium decreased: 365 reports
• Blood test: 131 reports
• Blood urea increased: 328 reports
• Blood uric acid increased: 112 reports
• Blood urine present: 343 reports
• Body height decreased: 456 reports
• Body temperature decreased: 101 reports
• Body temperature increased: 165 reports
• Bone density decreased: 214 reports
• Bone disorder: 282 reports
• Bone pain: 860 reports
• Bradycardia (abnormally slow heart action): 625 reports
• Breast cancer: 379 reports
• Breast pain: 130 reports
• Breathing difficulty: 7,468 reports
• Breathing - slowed or stopped: 197 reports
• Broken bone: 163 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1,245 reports
• Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 139 reports
• Burning sensation: 1,010 reports
• Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 243 reports
• Cardiac arrest: 742 reports
• Cardiac disorder: 1,245 reports
• Cardiac failure: 1,104 reports
• Cardiac failure congestive: 1,281 reports
• Cardiac flutter (abnormal heart rhythm): 123 reports
• Cardiac murmur (an heart sound in valve abnormality): 166 reports
• Cardiac valve disease (heart valve disease): 111 reports
• Cardiogenic shock (inadequate circulation of blood): 106 reports
• Cardiomyopathy (weakening of the heart muscle): 135 reports
• Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 446 reports
• Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 245 reports
• Cataract (clouding of the lens inside the eye): 1,188 reports
• Cellulitis (infection under the skin): 672 reports
• Cerebral haemorrhage (bleeding within the brain): 339 reports
• Cerebral infarction (less blood supply to brain resulting tissue damage): 226 reports
• Chest pain: 3,629 reports
• Chills (felling of cold): 1,212 reports
• Choking sensation (feeling of obstruction in respiratory system): 119 reports
• Cholecystitis (infection of gallbladder): 125 reports
• Chronic kidney disease: 4,803 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 795 reports
• Circulatory collapse: 172 reports
• Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 328 reports
• Colitis (inflammation of colon): 347 reports
• Colon cancer: 178 reports
• Completed suicide (act of taking one's own life): 705 reports
• Concussion (short loss of normal brain function in response to a head injury): 123 reports
• Condition: 1,372 reports
• Confusion: 445 reports
• Confusional state: 1,799 reports
• Conjunctivitis (pink eye): 170 reports
• Consciousness - decreased: 223 reports
• Constipation: 3,008 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 289 reports
• Coronary artery occlusion (complete obstruction of blood flow in a coronary artery): 345 reports
• Coronary heart disease (narrowing or blockage of the coronary arteries): 367 reports
• Cough: 4,681 reports
• Coughing up blood: 329 reports
• C-reactive protein increased: 203 reports
• Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 290 reports
• Crying: 337 reports
• Cuts and puncture wounds: 130 reports
• Cyst (a closed sac): 171 reports
• Death: 3,417 reports
• Decreased activity: 197 reports
• Decreased immune responsiveness: 217 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 566 reports
• Dehydration (dryness resulting from the removal of water): 1,742 reports
• Delirium (wild excitement): 235 reports
• Delusion (a false belief or opinion): 149 reports
• Dementia (madness): 255 reports
• Dementia alzheimer's type (loss of mental ability with alzheimer's symptom): 139 reports
• Dengue fever: 131 reports
• Dental caries: 153 reports
• Depressed level of consciousness: 251 reports
• Depressed mood: 755 reports
• Depression: 2,416 reports
• Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 217 reports
• Dermatitis allergic (inflammation of the skin due allergic reaction): 113 reports
• Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 181 reports
• Device related infection: 139 reports
• Diabetes: 1,357 reports
• Diabetes mellitus inadequate control: 286 reports
• Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 313 reports
• Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus): 146 reports
• Diarrhea: 8,336 reports
• Diarrhea haemorrhagic: 116 reports
• Diplopia (double vision): 291 reports
• Discomfort: 630 reports
• Disease progression: 679 reports
• Disease recurrence: 254 reports
• Disturbance in attention: 363 reports
• Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 441 reports
• Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 130 reports
• Dizziness: 7,390 reports
• Dizziness postural: 166 reports
• Drowsiness: 2,339 reports
• Drug administration error: 200 reports
• Drug dependence: 210 reports
• Drug effect decreased: 425 reports
• Drug eruption (adverse drug reaction of the skin): 117 reports
• Drug hypersensitivity: 1,536 reports
• Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications): 209 reports
• Drug ineffective: 7,816 reports
• Drug intolerance (drug sensitivity): 701 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 226 reports
• Dry eyes (lack of adequate tears): 539 reports
• Dry mouth: 1,165 reports
• Dry skin: 969 reports
• Dry throat: 183 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 417 reports
• Dyspnea exertional: 622 reports
• Dysstasia (difficulty in standing): 595 reports
• Ear discomfort: 155 reports
• Ear pain: 301 reports
• Eating disorder: 395 reports
• Ecchymosis (a discoloration of the skin resulting from bleeding underneath): 111 reports
• Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 235 reports
• Ejection fraction decreased (systolic heart failure): 192 reports
• Electrocardiogram qt prolonged: 268 reports
• Emotional disorder: 210 reports
• Emotional distress: 765 reports
• Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 152 reports
• Encephalopathy (functioning of the brain is affected by some agent or condition): 173 reports
• Enlarged heart: 265 reports
• Erection problems: 285 reports
• Erythema multiforme (a type of hypersensitivity reaction): 247 reports
• Exostosis (formation of new bone on the surface of a bone): 179 reports
• Eye discharge: 106 reports
• Eye disorder: 422 reports
• Eye haemorrhage (bleeding in the eye): 295 reports
• Eye infection: 169 reports
• Eye irritation: 433 reports
• Eyelid oedema (eyelids are swollen and contain excessive fluid): 102 reports
• Eye pain: 627 reports
• Eye pruritus (eye itching): 275 reports
• Eye swelling: 373 reports
• Face oedema (swelling of face): 141 reports
• Faeces discolored: 359 reports
• Fainting (loss of consciousness and postural tone): 1,508 reports
• Fall: 4,907 reports
• Fatigue (feeling of tiredness): 10,299 reports
• Fear: 318 reports
• Febrile neutropenia (fever with reduced white blood cells): 297 reports
• Feeding disorder (when children refuse to eat certain food groups): 301 reports
• Feeling cold: 451 reports
• Feeling hot: 653 reports
• Feeling jittery: 148 reports
• Feeling of despair: 122 reports
• Femur fracture: 265 reports
• Fever: 3,324 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 326 reports
• Flank pain (a distressing sensation experienced around the lower back and the upper abdomen): 105 reports
• Flatulence (flatus expelled through the anus): 851 reports
• Fluid overload (too much fluid in the blood): 207 reports
• Fluid retention (an abnormal accumulation of fluid in the blood): 789 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 177 reports
• Foot deformity (functional disability of foot): 199 reports
• Foot fracture: 245 reports
• Full blood count decreased: 333 reports
• Fungal infection: 359 reports
• Furuncle (infection of the hair follicle): 103 reports
• Gait disturbance: 3,307 reports
• Gallbladder disorder: 237 reports
• Gallstones (stone formation by bile component): 542 reports
• Gamma-glutamyltransferase increased: 127 reports
• Gastric disorder (disease of stomach): 635 reports
• Gastric haemorrhage (bleeding stomach): 109 reports
• Gastric ulcer (stomach ulcer): 493 reports
• Gastritis (inflammation of stomach): 515 reports
• Gastroenteritis (inflammation of stomach and intestine): 188 reports
• Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection): 198 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1,448 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 661 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 1,511 reports
• Gastrointestinal infection (infection of stomach and intestine): 136 reports
• Gastrointestinal pain: 123 reports
• Generalised oedema (swelling all over the body): 175 reports
• General physical health deterioration (weak health status): 811 reports
• Gingival bleeding (bleeding gums): 197 reports
• Gingival pain (gum pain): 113 reports
• Glaucoma (increased fluid pressure in the eye with vision loss): 392 reports
• Glomerular filtration rate decreased: 239 reports
• Glossodynia (a burning or painful sensation in the tongue): 236 reports
• Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 130 reports
• Glycosylated haemoglobin increased: 353 reports
• Gout (uric acid crystals building up in the body): 373 reports
• Groin pain: 182 reports
• Haematemesis (vomiting of blood): 308 reports
• Haematochezia (passage of stools containing blood): 533 reports
• Haematocrit decreased: 318 reports
• Haematoma (collection of blood outside the blood vessels): 381 reports
• Haematuria (presence of blood in urine): 498 reports
• Haemoglobin decreased: 1,715 reports
• Haemorrhage (bleeding): 1,013 reports
• Haemorrhage intracranial (bleeding within the skull): 201 reports
• Haemorrhagic anaemia (anaemia due to excessive bleeding): 156 reports
• Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain): 171 reports
• Haemorrhoids (a swollen vein or group of veins in the region of the anus): 299 reports
• Hair color changes: 357 reports
• Hair disorder: 299 reports
• Hair loss: 2,504 reports
• Hallucinations (sensations that appear real but are created by your mind): 748 reports
• Hallucination, visual (seeing things that aren't there): 185 reports
• Headache (pain in head): 6,823 reports
• Head discomfort: 308 reports
• Head injury: 1,904 reports
• Hearing loss: 344 reports
• Heart attack: 1,767 reports
• Heart disease: 246 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 1,366 reports
• Heart rate decreased: 539 reports
• Heart rate increased: 1,152 reports
• Heart rate irregular: 430 reports
• Hemiparesis (weakness on one side of the body): 228 reports
• Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 162 reports
• Hepatic enzyme increased: 426 reports
• Hepatic failure (liver failure): 138 reports
• Hepatic steatosis (fatty liver disease): 425 reports
• Hepatitis (inflammation of the liver): 268 reports
• Hepatomegaly (abnormal enlargement of the liver): 117 reports
• Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 319 reports
• Herpes zoster: 649 reports
• Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 264 reports
• Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 104 reports
• High blood cholesterol: 1,330 reports
• High blood pressure: 7,956 reports
• Hip fracture: 364 reports
• Hip joint replacement: 136 reports
• Hoarseness or changing voice: 1,032 reports
• Hospitalisation: 710 reports
• Hot flush (sudden feelings of heat): 639 reports
• Hypercalcaemia (elevated calcium (ca+) level in the blood): 162 reports
• Hyperglycemia (high blood sugar): 604 reports
• Hyperhidrosis (abnormally increased sweating): 1,432 reports
• Hyperkalemia (damage to or disease of the kidney): 1,113 reports
• Hyperkeratosis (thickening of the outer layer of the skin): 129 reports
• Hyperlipidaemia (presence of excess lipids in the blood): 209 reports
• Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 416 reports
• Hypersensitivity: 1,648 reports
• Hypertensive crisis: 298 reports
• Hyperthyroidism (over activity of the thyroid gland): 106 reports
• Hypoacusis (loss of hearing): 541 reports
• Hypoaesthesia (reduced sense of touch or sensation): 1,882 reports
• Hypoaesthesia oral (reduced sense of touch or sensation in mouth): 156 reports
• Hypocalcaemia (levels of calcium in blood serum are abnormally low): 203 reports
• Hypoglycemia (low blood sugar): 729 reports
• Hypokalemia (low potassium): 571 reports
• Hypokinesia (decreased bodily movement): 196 reports
• Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 221 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 900 reports
• Hypophagia (reduced food intake): 391 reports
• Hypotension (abnormally low blood pressure): 3,559 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 365 reports
• Idiopathic pulmonary fibrosis (chronic lung disease): 231 reports
• Ill-defined disorder: 404 reports
• Immune system disorder: 143 reports
• Immunodeficiency: 332 reports
• Impaired driving ability: 108 reports
• Impaired healing: 344 reports
• Impaired work ability: 131 reports
• Inappropriate antidiuretic hormone secretion: 129 reports
• Incontinence (lack of moderation or self-control): 147 reports
• Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone): 194 reports
• Indigestion: 1,285 reports
• Infarction (obstruction of the blood supply to an organ or region of tissue): 245 reports
• Infection: 1,231 reports
• Inflammation: 646 reports
• Influenza like illness: 621 reports
• Infusion related reaction: 378 reports
• Initial insomnia (feeling of inadequate or poor-quality sleep): 107 reports
• Injection site bruising: 379 reports
• Injection site erythema (redness at injection site): 477 reports
• Injection site extravasation (flow of (blood or lymph) from injection site): 114 reports
• Injection site haemorrhage (bleeding from injection site): 479 reports
• Injection site mass: 292 reports
• Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site): 142 reports
• Injection site pain: 1,410 reports
• Injection site pruritus (severe itching at injection site): 375 reports
• Injection site rash: 125 reports
• Injection site reaction: 263 reports
• Injection site swelling: 273 reports
• Injury: 349 reports
• Insomnia (sleeplessness): 3,184 reports
• International normalised ratio increased: 386 reports
• Interstitial lung disease: 315 reports
• Interstitial nephritis (inflammation of the kidney): 574 reports
• Intervertebral disc degeneration (spinal disc degeneration): 172 reports
• Intervertebral disc protrusion (spinal disc protrusion): 410 reports
• Intestinal obstruction: 383 reports
• Intraocular pressure increased: 157 reports
• Iron deficiency anaemia: 176 reports
• Irritability: 372 reports
• Irritable bowel syndrome: 225 reports
• Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain): 236 reports
• Itching: 3,644 reports
• Jaundice - yellow skin (a yellowish pigmentation of the skin): 205 reports
• Joint dislocation (a joint position is changed from normal position): 145 reports
• Joint injury: 326 reports
• Joint pain: 5,488 reports
• Joint range of motion decreased (disease of joint movement): 185 reports
• Joint stiffness: 268 reports
• Joint swelling: 1,500 reports
• Kidney infection: 319 reports
• Kidney infection (pyelonephritis): 105 reports
• Kidney stones: 677 reports
• Knee joint replacement: 248 reports
• Lacrimation increased: 410 reports
• Lactic acidosis (low ph in body tissues): 405 reports
• Laryngitis (inflammation of the larynx): 137 reports
• Left ventricular dysfunction: 114 reports
• Leukocytosis (increased white blood cells): 181 reports
• Leukopenia (less number of white blood cells in blood): 185 reports
• Ligament sprain (ligament stretched): 165 reports
• Limb discomfort (discomfort in leg): 494 reports
• Limb injury: 525 reports
• Lip swelling: 356 reports
• Liver disorder (liver diseases): 427 reports
• Liver injury: 172 reports
• Localised infection (infection at the single location): 350 reports
• Local swelling (swelling at the site of some application of substance or injury): 233 reports
• Loss of consciousness: 1,428 reports
• Loss of employment: 160 reports
• Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding): 173 reports
• Lower limb fracture: 180 reports
• Lower respiratory tract infection: 316 reports
• Low tissue oxygen: 182 reports
• Lung disorder (lung disease): 603 reports
• Lung infection: 218 reports
• Lung neoplasm malignant (cancer tumour of lung): 241 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 329 reports
• Lymphocyte count decreased: 132 reports
• Lymphoma (cancer that begins in immune system cells): 131 reports
• Macular degeneration (painless eye condition that leads to the gradual loss of central vision): 190 reports
• Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 106 reports
• Malaise (a feeling of general discomfort or uneasiness): 5,885 reports
• Malignant melanoma (skin cancer rises from melancytes): 158 reports
• Malignant neoplasm progression (cancer tumour came back): 480 reports
• Malnutrition (condition that results from eating a diet in which certain nutrients are lacking): 130 reports
• Melaena (the passage of black, tarry stools): 245 reports
• Memory loss: 2,703 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 234 reports
• Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 181 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 246 reports
• Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 341 reports
• Metastases to liver (cancer spreads to liver): 130 reports
• Metastases to lung (cancer spreads to lung): 131 reports
• Micturition urgency (urgency to pass the urine): 146 reports
• Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night): 167 reports
• Migraine (headache): 599 reports
• Mitral valve incompetence (inefficient heart valve): 147 reports
• Mobility decreased (ability to move is reduced): 859 reports
• Mood swings (an extreme or rapid change in mood): 311 reports
• Mouth haemorrhage (bleeding from mouth): 159 reports
• Mouth ulcers: 198 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 388 reports
• Movement - uncoordinated: 127 reports
• Mucosal inflammation (infection of mucous membrane): 155 reports
• Multi-organ failure (multisystem organ failure): 131 reports
• Multiple myeloma (cancer of the plasma cells): 261 reports
• Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 228 reports
• Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 440 reports
• Muscle aches (muscle pain): 2,150 reports
• Muscle atrophy (a decrease in the mass of the muscle): 143 reports
• Muscle function loss: 153 reports
• Muscle spasms (muscle contraction): 2,479 reports
• Muscle strain (an injury to a muscle in which the muscle fibres tear): 132 reports
• Muscle tightness: 194 reports
• Muscle twitching: 235 reports
• Musculoskeletal chest pain (pain in chest muscle or nerve or bones): 224 reports
• Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 299 reports
• Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 214 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 903 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1,077 reports
• Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 129 reports
• Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 105 reports
• Myopathy (a muscular disease in which the muscle fibres do not function): 141 reports
• Nail disorder (disease of nail): 142 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 748 reports
• Nasopharyngitis (inflammation of the nasopharynx): 1,995 reports
• Nausea (feeling of having an urge to vomit): 7,739 reports
• Nausea and vomiting: 4,234 reports
• Neck pain: 762 reports
• Neoplasm malignant (cancer tumour): 419 reports
• Neoplasm progression (growth of tumour): 293 reports
• Nephrogenic anaemia (anaemia due to kidney disease): 756 reports
• Nephropathy (damage to or disease of a kidney): 268 reports
• Nerve compression: 195 reports
• Nerve injury: 159 reports
• Nervousness: 774 reports
• Nervous system disorder (a general class of medical conditions affecting the nervous system): 198 reports
• Neuralgia (pain in one or more nerves): 349 reports
• Neuropathy peripheral (surface nerve damage): 1,232 reports
• Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 267 reports
• Nightmares (unpleasant dreams): 357 reports
• Night sweats (sweating in night): 317 reports
• Nodule (a small rock or mineral cluster): 207 reports
• Nosebleed (bleeding from nose): 1,170 reports
• Obstructive airways disorder (a progressive disease that makes it hard to breathe): 134 reports
• Ocular discomfort (a generic expression when there is lack of ease in/about the eyes): 127 reports
• Ocular hyperaemia (an abnormally large amount of blood in eye): 448 reports
• Oedema (fluid collection in tissue): 629 reports
• Oedema peripheral (superficial swelling): 1,694 reports
• Oesophagitis (inflammation of oesophagus): 112 reports
• Oligohydramnios (a condition in pregnancy characterized by a deficiency of amniotic fluid): 101 reports
• Onychoclasis (breaking of the nails): 127 reports
• Oral candidiasis (fungal infection of mouth): 129 reports
• Oral discomfort (pain or irritation in mouth): 164 reports
• Oral disorder (mouth disease): 124 reports
• Oral herpes (viral infection of mouth): 165 reports
• Oral mucosal blistering (mouth ulcer): 143 reports
• Oral pain: 507 reports
• Oropharyngeal discomfort (pain or irritation of oropharynx): 109 reports
• Oropharyngeal pain: 1,230 reports
• Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 232 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1,007 reports
• Osteomyelitis (infection of bone): 226 reports
• Osteonecrosis of jaw (death of bone of jaw): 163 reports
• Osteopenia (a condition where bone mineral density is lower than normal): 247 reports
• Osteoporosis (bones weak and more likely to break): 627 reports
• Otitis (ear infection): 281 reports
• Overdose: 644 reports
• Oxygen saturation decreased: 580 reports
• Pain: 6,631 reports
• Pain in extremity: 4,708 reports
• Pain in jaw: 305 reports
• Pain of skin: 160 reports
• Paleness (unusual lightness of skin colour): 312 reports
• Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome): 174 reports
• Pancreatic carcinoma (pancreatic cancer): 138 reports
• Pancreatitis (inflammation of pancreas): 449 reports
• Pancreatitis acute (sudden inflammation of pancreas): 221 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 305 reports
• Panic disorder: 328 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 1,671 reports
• Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect): 124 reports
• Parkinson's disease: 270 reports
• Pericardial effusion (fluid around the heart): 291 reports
• Peripheral coldness: 185 reports
• Peripheral swelling: 3,051 reports
• Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 109 reports
• Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal): 189 reports
• Pharyngitis (inflammation of the pharynx, causing a sore throat): 156 reports
• Photophobia (extreme sensitivity to light): 165 reports
• Photosensitivity reaction: 178 reports
• Platelet count increased: 359 reports
• Pleural effusion (water on the lungs): 750 reports
• Pneumonia: 4,299 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 140 reports
• Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung): 133 reports
• Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 647 reports
• Polyp: 124 reports
• Poor quality sleep: 253 reports
• Postoperative wound infection: 122 reports
• Post procedural complication: 209 reports
• Post procedural haemorrhage (post procedural bleeding): 199 reports
• Post procedural infection: 109 reports
• Pre-existing condition improved: 196 reports
• Presyncope: 271 reports
• Primary pulmonary hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 107 reports
• Procedural pain: 212 reports
• Productive cough: 742 reports
• Prostate cancer: 274 reports
• Prostatic specific antigen increased: 264 reports
• Protein - urine: 297 reports
• Pruritus generalised (generalized itching): 321 reports
• Psoriasis (immune-mediated disease that affects the skin): 1,339 reports
• Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 412 reports
• Psychiatric symptom: 145 reports
• Psychological trauma: 248 reports
• Psychotic disorder: 114 reports
• Pulmonary congestion (congestion in the lungs): 169 reports
• Pulmonary embolism (blockage of the main artery of the lung): 732 reports
• Pulmonary hypertension (increase in blood pressure in the lung artery): 311 reports
• Pulmonary mass: 240 reports
• Pulmonary oedema (fluid accumulation in the lungs): 731 reports
• Pulmonary thrombosis (scarring in the lungs): 136 reports
• Quality of life decreased: 136 reports
• Rash erythematous (redness of the skin): 392 reports
• Rashes (redness): 5,681 reports
• Rash macular (small, flat red spots): 408 reports
• Rash maculo-papular (red area on the skin that is covered with small confluent bumps): 112 reports
• Rash papular (redness with papule): 163 reports
• Rash pruritic (redness with itching): 583 reports
• Rectal haemorrhage (bleeding from anus): 624 reports
• Red blood cell count decreased: 472 reports
• Renal cell carcinoma (a kidney cancer): 195 reports
• Renal cyst (kidney cyst): 163 reports
• Renal disorder (kidney disease): 850 reports
• Renal failure acute (rapid kidney dysfunction): 621 reports
• Renal failure chronic (long lasting kidney dysfunction): 122 reports
• Renal impairment (severely reduced kidney function): 1,368 reports
• Renal injury (kidney injury): 1,279 reports
• Renal pain (kidney pain): 181 reports
• Renal tubular necrosis (death of kidney tubules): 201 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 707 reports
• Respiratory disorder (respiratory disease): 267 reports
• Respiratory distress (difficulty in breathing): 248 reports
• Respiratory tract congestion (blockage on respiratory system): 168 reports
• Respiratory tract infection: 290 reports
• Restless leg syndrome (a powerful urge to move your legs): 219 reports
• Retching (strong involuntary effort to vomit): 276 reports
• Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue): 152 reports
• Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 355 reports
• Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 1,057 reports
• Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 191 reports
• Rib fracture: 295 reports
• Rickets (softening of bones): 222 reports
• Road traffic accident: 398 reports
• Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 202 reports
• Scab (a hard coating on the skin formed during the wound healing): 126 reports
• Scar: 149 reports
• Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 276 reports
• Scoliosis (a medical condition in which a person's spine is curved from side to side): 108 reports
• Scratch: 135 reports
• Seasonal allergy (allergic condition due to certain season): 212 reports
• Secretion discharge: 187 reports
• Sedation: 144 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 804 reports
• Sensory disturbance (sense disturbance): 162 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 1,064 reports
• Septic shock (shock due to blood infection): 308 reports
• Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 103 reports
• Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 134 reports
• Sinus bradycardia (an unusually slow heartbeat due to heart disease): 124 reports
• Sinus congestion (blockage of sinus): 157 reports
• Sinus disorder (disease of sinus): 287 reports
• Sinusitis (inflammation of sinus): 1,374 reports
• Skin atrophy (wasting of skin): 103 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 776 reports
• Skin burning sensation: 245 reports
• Skin cancer: 254 reports
• Skin - clammy: 196 reports
• Skin discoloration: 823 reports
• Skin discoloration - bluish (bluish colour of skin): 125 reports
• Skin disorder (skin disease): 331 reports
• Skin exfoliation (removal of the oldest dead skin cells): 711 reports
• Skin fissures (a crack in the skin): 181 reports
• Skin haemorrhage (bleeding into skin): 152 reports
• Skin irritation: 184 reports
• Skin ulcer: 416 reports
• Sleep apnea syndrome: 469 reports
• Sleep disorder: 831 reports
• Sluggishness (lacking alertness): 160 reports
• Small intestinal obstruction (blockage in small intestine): 115 reports
• Smell - impaired: 135 reports
• Sneezing: 288 reports
• Speech disorder: 627 reports
• Speech impairment (adult) (inability to speak (adult)): 637 reports
• Spinal disorder (disease of spine a back bone): 218 reports
• Spinal fracture (fracture in one of vertebrae): 241 reports
• Spinal osteoarthritis (joint cartilage loss in spine): 184 reports
• Spinal pain (pain in spine): 319 reports
• Splenomegaly (enlargement of spleen): 235 reports
• Squamous cell carcinoma (a cancer of a kind of epithelial cell): 135 reports
• Stable angina (a constant chest pain): 421 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 297 reports
• Stent: 115 reports
• Stomatitis (inflammation of mucous membrane of mouth): 885 reports
• Stress and anxiety: 3,505 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1,820 reports
• Subdural haematoma (blood collects between the skull and the surface of the brain): 167 reports
• Suicidal ideation: 422 reports
• Suicide attempt: 125 reports
• Surgery: 421 reports
• Swallowing difficulty: 1,020 reports
• Swelling: 1,274 reports
• Swelling face: 713 reports
• Swollen tongue (swelling of tongue): 381 reports
• Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 199 reports
• Tachypnea: 119 reports
• Taste - impaired: 931 reports
• Temperature intolerance (inability to go in temperature): 112 reports
• Tendonitis (a condition that causes pain and swelling of tendons): 186 reports
• Tendon rupture (tear of tendon): 183 reports
• The flu (the flu is caused by an influenza virus): 1,730 reports
• Therapeutic response decreased (less preventive response): 331 reports
• Therapeutic response unexpected: 516 reports
• Thirst: 213 reports
• Throat irritation: 532 reports
• Throat tightness: 258 reports
• Thrombocytopenia (decrease of platelets in blood): 2,195 reports
• Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot): 113 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 994 reports
• Thyroid diseases: 354 reports
• Tinnitus (a ringing in the ears): 551 reports
• Tooth abscess (pus formation in tooth): 301 reports
• Toothaches (tooth pain): 193 reports
• Tooth disorder (tooth disease): 339 reports
• Tooth extraction: 106 reports
• Tooth fracture: 169 reports
• Tooth loss: 189 reports
• Torsade de pointes (a abnormal heart rate with abnormal beating pattern): 108 reports
• Transaminases increased: 139 reports
• Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 507 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 1,861 reports
• Tricuspid valve incompetence (inefficient heart valve): 109 reports
• Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 118 reports
• Tumor: 385 reports
• Type 2 diabetes: 314 reports
• Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 218 reports
• Unresponsive to stimuli: 194 reports
• Upper-airway cough syndrome: 125 reports
• Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding): 342 reports
• Upper limb fracture: 261 reports
• Upper respiratory tract infection: 608 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 437 reports
• Urinary retention (the inability to completely or partially empty the bladder): 366 reports
• Urinary tract infection: 3,313 reports
• Urination - excessive at night: 202 reports
• Urination - excessive volume: 125 reports
• Urination - painful: 514 reports
• Urine output decreased: 173 reports
• Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream): 142 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 1,069 reports
• Vaginal bleeding: 247 reports
• Varicose vein (veins that have become enlarged and tortuous): 145 reports
• Vasculitis (inflammation of a blood vessel or blood vessels): 118 reports
• Venous occlusion (the blocking of venous return): 107 reports
• Ventricular extrasystoles (premature cardiac contraction): 156 reports
• Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 163 reports
• Viral infection: 372 reports
• Vision blurred: 1,619 reports
• Visual acuity reduced (reduced clearness of vision): 380 reports
• Visual impairment: 1,591 reports
• Vitamin d decreased: 142 reports
• Vitreous floaters (spots before the eyes): 143 reports
• Weakness: 6,666 reports
• Weight decreased: 4,294 reports
• Weight fluctuation: 170 reports
• Weight increased: 2,511 reports
• Weight loss: 290 reports
• Wheezing (a high-pitched whistling sound made while you breath): 718 reports
• White blood cell count decreased: 1,134 reports
• White blood cell count increased: 520 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 283 reports
• Wound: 386 reports
• Wound infection: 147 reports
• Wrist fracture: 126 reports
• Yellow skin: 141 reports

• Contact lens intolerance (209 reports)

All the drugs that are associated with Contact lens intolerance:

• Contact lens intolerance (140 drugs)

All the conditions that are associated with Contact lens intolerance:

• Contact lens intolerance (73 conditions)

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