Lunesta and Intervertebral disc disorder - a phase IV clinical study of FDA data


Intervertebral disc disorder is found among people who take Lunesta, especially for people who are female, 50-59 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Lunesta and have Intervertebral disc disorder. It is created by eHealthMe based on reports of 23,837 people who have side effects when taking Lunesta from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 06, 2023

23,837 people reported to have side effects when taking Lunesta.
Among them, 32 people (0.13%) have Intervertebral disc disorder.

What is Lunesta?

Lunesta has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 25,568 Lunesta users for its effectiveness, alternative drugs and more.

What is Intervertebral disc disorder?

Intervertebral disc disorder (spinal disc disorder) is found to be associated with 1,115 drugs and 574 conditions by eHealthMe.

Number of Lunesta and Intervertebral disc disorder reports submitted per year:

Could Lunesta cause Intervertebral disc disorder?

Time on Lunesta when people have Intervertebral disc disorder *:

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 50 %

Gender of people who have Intervertebral disc disorder when taking Lunesta *:

  • female: 84.38 %
  • male: 15.62 %

Age of people who have Intervertebral disc disorder when taking Lunesta *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 3.12 %
  • 40-49: 25.0 %
  • 50-59: 62.5 %
  • 60+: 9.38 %

Common drugs people take besides Lunesta *:

  1. Nexium: 21 people, 65.62%
  2. Zometa: 20 people, 62.50%
  3. Lisinopril: 20 people, 62.50%
  4. Aredia: 19 people, 59.38%
  5. Flexeril: 19 people, 59.38%
  6. Oxycontin: 17 people, 53.12%
  7. Cephalexin: 15 people, 46.88%
  8. Ambien: 15 people, 46.88%
  9. Lyrica: 15 people, 46.88%
  10. Celebrex: 15 people, 46.88%

Common side effects people have besides Intervertebral disc disorder *:

  1. Pain: 21 people, 65.62%
  2. Stress And Anxiety: 20 people, 62.50%
  3. Fall: 20 people, 62.50%
  4. Pain In Extremity: 19 people, 59.38%
  5. Hypoaesthesia (reduced sense of touch or sensation): 19 people, 59.38%
  6. Bone Pain: 19 people, 59.38%
  7. Tooth Loss: 19 people, 59.38%
  8. Bone Lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 18 people, 56.25%
  9. Neuropathy Peripheral (surface nerve damage): 17 people, 53.12%
  10. Osteoporosis (bones weak and more likely to break): 16 people, 50.00%

Common conditions people have *:

  1. Breast Cancer: 5 people, 15.62%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 15.62%
  3. Metastases To Bone (cancer spreads to bone): 5 people, 15.62%
  4. Psychotic Disorder: 2 people, 6.25%
  5. Panic Disorder: 2 people, 6.25%
  6. Diabetes: 2 people, 6.25%
  7. Stress And Anxiety: 2 people, 6.25%
  8. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 3.12%
  9. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 3.12%
  10. Arthropathy: 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Lunesta and have Intervertebral disc disorder?

Check whether Intervertebral disc disorder is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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Expand to all the drugs that have ingredients of eszopiclone:

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Common Lunesta side effects:

Browse all side effects of Lunesta:

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Intervertebral disc disorder treatments and more:

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Common drugs associated with Intervertebral disc disorder:

All the drugs that are associated with Intervertebral disc disorder:

Common conditions associated with Intervertebral disc disorder:

All the conditions that are associated with Intervertebral disc disorder:

How the study uses the data?

The study uses data from the FDA. It is based on eszopiclone (the active ingredients of Lunesta) and Lunesta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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