Lupron and Fatigue - a phase IV clinical study of FDA data


Fatigue is found among people who take Lupron, especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Lupron and have Fatigue. It is created by eHealthMe based on reports of 37,338 people who have side effects when taking Lupron from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Apr, 13, 2023

37,338 people reported to have side effects when taking Lupron.
Among them, 4,294 people (11.5%) have Fatigue.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 37,949 Lupron users for its effectiveness, alternative drugs and more.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 5,391 drugs and 6,174 conditions by eHealthMe.

Number of Lupron and Fatigue reports submitted per year:

Could Lupron cause Fatigue?

Time on Lupron when people have Fatigue *:

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Gender of people who have Fatigue when taking Lupron*:

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Age of people who have Fatigue when taking Lupron *:

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Common drugs people take besides Lupron *:

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Common side effects people have besides Fatigue *:

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Common conditions people have *:

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* Approximation only. Some reports may have incomplete information.

Do you take Lupron and have Fatigue?

Check whether Fatigue is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Fatigue and when was it recovered:

Expand to all the drugs that have ingredients of leuprolide acetate:

Alternative drugs to, pros and cons of Lupron:

Common Lupron side effects:

Browse all side effects of Lupron:

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Fatigue treatments and more:

COVID vaccines that are related to Fatigue:

Common drugs associated with Fatigue:

All the drugs that are associated with Fatigue:

Common conditions associated with Fatigue:

All the conditions that are associated with Fatigue:

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Lupron) and Lupron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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