Lupron and Pain - a phase IV clinical study of FDA data
Summary:
We study 39,915 people who have side effects when taking Lupron. Pain is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Zometa and have Metastases to bone.
The phase IV clinical study analyzes which people take Lupron and have Pain. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
39,915 people reported to have side effects when taking Lupron.
Among them, 2,647 people (6.63%) have Pain.
What is Lupron?
Lupron has active ingredients of leuprolide acetate. It is used in endometriosis. Currently, eHealthMe is studying from 40,539 Lupron users.
What is Pain?
Pain is found to be associated with 5,176 drugs and 5,716 conditions by eHealthMe. Currently, we are studying 1,088,541 people who have Pain.
Number of Lupron and Pain reports submitted per year:

Time on Lupron when people have Pain *:
Gender of people who have Pain when taking Lupron*:
Age of people who have Pain when taking Lupron *:
Common drugs people take besides Lupron *:
Common side effects people have besides Pain *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Lupron and have Pain?
Check whether Pain is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Sharma SP, Muggia F, "Supraventricular tachycardia and urticaria complicating leuprolide-induced ovarian suppression in a young woman with breast cancer: a case report", ecancermedicalscience, 2016 Jan .
- Pong YH, Lu YC, Tsai VF, Huang PL, Hsieh JT, Chang HC, "Acute manic and psychotic symptoms following subcutaneous leuprolide acetate in a male patient without prior psychiatric history: A case report and literature review", Urological Science, 2014 Mar .
Related studies
Lupron side effects by duration, gender and age:
- Lupron side effects (40,539 reports)
Pain treatments and more:
- Pain (1,088,541 reports)
Common drugs associated with Pain:
- Oxycontin: 55,916 reports
- Humira: 55,823 reports
- Enbrel: 50,591 reports
- Methotrexate: 44,785 reports
- Prednisone: 43,232 reports
- Lyrica: 30,908 reports
- Xeljanz: 26,984 reports
- Oxycodone: 26,816 reports
- Aspirin: 25,243 reports
- Orencia: 23,720 reports
All the drugs that are associated with Pain:
- Pain (5,176 drugs)
Common conditions associated with Pain:
- Rheumatoid arthritis: 88,017 reports
- Multiple sclerosis: 29,170 reports
- High blood pressure: 19,549 reports
All the conditions that are associated with Pain:
- Pain (5,716 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Lupron) and Lupron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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