Lyrica and Non-hodgkin's lymphoma - a phase IV clinical study of FDA data


Non-hodgkin's lymphoma is found among people who take Lyrica, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Lyrica and have Non-hodgkin's lymphoma. It is created by eHealthMe based on reports of 243,378 people who have side effects when taking Lyrica from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 06, 2023

243,378 people reported to have side effects when taking Lyrica.
Among them, 90 people (0.04%) have Non-hodgkin's lymphoma.

What is Lyrica?

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 249,011 Lyrica users for its effectiveness, alternative drugs and more.

What is Non-hodgkin's lymphoma?

Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system) is found to be associated with 1,615 drugs and 1,217 conditions by eHealthMe.

Number of Lyrica and Non-hodgkin's lymphoma reports submitted per year:

Could Lyrica cause Non-hodgkin's lymphoma?

Time on Lyrica when people have Non-hodgkin's lymphoma *:

  • < 1 month: 46.15 %
  • 1 - 6 months: 38.46 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 15.38 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Non-hodgkin's lymphoma when taking Lyrica *:

  • female: 51.16 %
  • male: 48.84 %

Age of people who have Non-hodgkin's lymphoma when taking Lyrica *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 3.9 %
  • 30-39: 0.0 %
  • 40-49: 9.09 %
  • 50-59: 29.87 %
  • 60+: 57.14 %

Common drugs people take besides Lyrica *:

  1. Cymbalta: 15 people, 16.67%
  2. Zofran: 10 people, 11.11%
  3. Xanax: 10 people, 11.11%
  4. Morphine: 9 people, 10.00%
  5. Revlimid: 9 people, 10.00%
  6. Famvir: 8 people, 8.89%
  7. Vitamin D3: 8 people, 8.89%
  8. Asa: 8 people, 8.89%
  9. Baby Aspirin: 8 people, 8.89%
  10. Ativan: 8 people, 8.89%

Common side effects people have besides Non-hodgkin's lymphoma *:

  1. Fall: 22 people, 24.44%
  2. Neuropathy Peripheral (surface nerve damage): 15 people, 16.67%
  3. Headache (pain in head): 14 people, 15.56%
  4. Nausea And Vomiting: 11 people, 12.22%
  5. Sleep Disorder: 11 people, 12.22%
  6. Back Pain: 10 people, 11.11%
  7. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 10 people, 11.11%
  8. Nausea (feeling of having an urge to vomit): 10 people, 11.11%
  9. Diarrhea: 9 people, 10.00%
  10. Pain In Extremity: 9 people, 10.00%

Common conditions people have *:

  1. Depression: 17 people, 18.89%
  2. High Blood Cholesterol: 11 people, 12.22%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 11 people, 12.22%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 11.11%
  5. Neuropathy Peripheral (surface nerve damage): 10 people, 11.11%
  6. Insomnia (sleeplessness): 10 people, 11.11%
  7. Nausea (feeling of having an urge to vomit): 8 people, 8.89%
  8. Thyroid Diseases: 8 people, 8.89%
  9. Multiple Myeloma (cancer of the plasma cells): 8 people, 8.89%
  10. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 8 people, 8.89%

* Approximation only. Some reports may have incomplete information.

Do you take Lyrica and have Non-hodgkin's lymphoma?

Check whether Non-hodgkin's lymphoma is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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Non-hodgkin's lymphoma treatments and more:

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Common drugs associated with Non-hodgkin's lymphoma:

All the drugs that are associated with Non-hodgkin's lymphoma:

Common conditions associated with Non-hodgkin's lymphoma:

All the conditions that are associated with Non-hodgkin's lymphoma:

How the study uses the data?

The study uses data from the FDA. It is based on pregabalin (the active ingredients of Lyrica) and Lyrica (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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