Macrobid and Vulvovaginal discomfort - a phase IV clinical study of FDA data


We study 7,986 people who have side effects when taking Macrobid. Vulvovaginal discomfort is found, especially among people who are 50-59 old, also take Coq10 and have Multiple sclerosis.

The phase IV clinical study analyzes which people take Macrobid and have Vulvovaginal discomfort. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 25, 2023

7,986 people reported to have side effects when taking Macrobid.
Among them, 11 people (0.14%) have Vulvovaginal discomfort.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is used in urinary tract infection. Currently, eHealthMe is studying from 8,852 Macrobid users.

What is Vulvovaginal discomfort?

Vulvovaginal discomfort is found to be associated with 834 drugs and 439 conditions by eHealthMe. Currently, we are studying 8,221 people who have Vulvovaginal discomfort.

Number of Macrobid and Vulvovaginal discomfort reports submitted per year:

Could Macrobid cause Vulvovaginal discomfort?

Age of people who have Vulvovaginal discomfort when taking Macrobid *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 28.57 %
  • 40-49: 14.29 %
  • 50-59: 42.86 %
  • 60+: 14.29 %

Common drugs people take besides Macrobid *:

  1. Lecithin: 3 people, 27.27%
  2. Gilenya: 3 people, 27.27%
  3. Baclofen: 3 people, 27.27%
  4. Coq10: 3 people, 27.27%
  5. Premarin: 2 people, 18.18%
  6. Linzess: 2 people, 18.18%
  7. Lunesta: 2 people, 18.18%
  8. Epipen: 2 people, 18.18%
  9. Narcan: 2 people, 18.18%
  10. Diflucan: 2 people, 18.18%

Common side effects people have besides Vulvovaginal discomfort *:

  1. Urination - Painful: 3 people, 27.27%
  2. Fatigue (feeling of tiredness): 3 people, 27.27%
  3. Weight Decreased: 2 people, 18.18%
  4. Malaise (a feeling of general discomfort or uneasiness): 2 people, 18.18%
  5. Hot Flush (sudden feelings of heat): 2 people, 18.18%
  6. Genital Herpes (herpes infection of genital): 2 people, 18.18%
  7. Nausea (feeling of having an urge to vomit): 2 people, 18.18%
  8. Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 2 people, 18.18%
  9. Feeling Hot: 2 people, 18.18%
  10. Chills (felling of cold): 2 people, 18.18%

Common conditions people have *:

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 27.27%
  2. Sleep Disorder: 2 people, 18.18%
  3. Pain: 2 people, 18.18%
  4. Hot Flush (sudden feelings of heat): 2 people, 18.18%
  5. Hormone Level Abnormal: 2 people, 18.18%
  6. Atrophic Vulvovaginitis (inflammation of the vulva): 2 people, 18.18%
  7. Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 2 people, 18.18%
  8. Vulvovaginal Dryness: 1 person, 9.09%
  9. Stress And Anxiety: 1 person, 9.09%
  10. Sexual Intercourse - Painful: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Vulvovaginal discomfort?

Check whether Vulvovaginal discomfort is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Vulvovaginal discomfort and when was it recovered:

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Alternative drugs to, pros and cons of Macrobid:

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Vulvovaginal discomfort treatments and more:

Common drugs associated with Vulvovaginal discomfort:

All the drugs that are associated with Vulvovaginal discomfort:

Common conditions associated with Vulvovaginal discomfort:

All the conditions that are associated with Vulvovaginal discomfort:

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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