Maxzide and Angle closure glaucoma - a phase IV clinical study of FDA data


Angle closure glaucoma is reported only by a few people who take Maxzide.

The phase IV clinical study analyzes which people take Maxzide and have Angle closure glaucoma. It is created by eHealthMe based on reports of 8,629 people who have side effects while taking Maxzide from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2022

8,629 people reported to have side effects when taking Maxzide.
Among them, 3 people (0.03%) have Angle closure glaucoma.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 8,915 Maxzide users for its effectiveness, alternative drugs and more.

What is Angle closure glaucoma?

Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity) is found to be associated with 691 drugs and 412 conditions by eHealthMe.

Number of Maxzide and Angle closure glaucoma reports submitted per year:

Could Maxzide cause Angle closure glaucoma?

Gender of people who have Angle closure glaucoma when taking Maxzide *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Angle closure glaucoma when taking Maxzide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Common drugs people take besides Maxzide *:

  1. Topiramate: 2 people, 66.67%
  2. Timoptic: 1 person, 33.33%
  3. Progesterone: 1 person, 33.33%
  4. Prednisolone Acetate: 1 person, 33.33%
  5. Estradiol: 1 person, 33.33%
  6. Brimonidine Tartrate: 1 person, 33.33%
  7. Acetazolamide: 1 person, 33.33%

Common side effects people have besides Angle closure glaucoma *:

  1. Photophobia (extreme sensitivity to light): 2 people, 66.67%
  2. Photopsia (presence of perceived flashes of light): 1 person, 33.33%
  3. Migraine (headache): 1 person, 33.33%
  4. Heart Rate Increased: 1 person, 33.33%

Common conditions people have *:

  1. Migraine Aggravated (worse headache): 1 person, 33.33%

* Approximation only. Some reports may have incomplete information.

Do you take Maxzide and have Angle closure glaucoma?

Check whether Angle closure glaucoma is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Angle closure glaucoma and when was it recovered:

Expand to all the drugs that have ingredients of hydrochlorothiazide; triamterene:

Alternative drugs to, pros and cons of Maxzide:

Common Maxzide side effects:

Browse all side effects of Maxzide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Angle closure glaucoma treatments and more:

COVID vaccines that are related to Angle closure glaucoma:

Common drugs associated with Angle closure glaucoma:

All the drugs that are associated with Angle closure glaucoma:

Common conditions associated with Angle closure glaucoma:

All the conditions that are associated with Angle closure glaucoma:

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; triamterene (the active ingredients of Maxzide) and Maxzide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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