Medroxyprogesterone acetate and Insomnia - a phase IV clinical study of FDA data


Insomnia is found among people who take Medroxyprogesterone acetate, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Medroxyprogesterone acetate and have Insomnia. It is created by eHealthMe based on reports of 11,778 people who have side effects when taking Medroxyprogesterone acetate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Dec, 08, 2022

11,778 people reported to have side effects when taking Medroxyprogesterone acetate.
Among them, 89 people (0.76%) have Insomnia.

What is Medroxyprogesterone acetate?

Medroxyprogesterone acetate has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 11,959 Medroxyprogesterone acetate users for its effectiveness, alternative drugs and more.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 4,595 drugs and 4,885 conditions by eHealthMe.

Number of Medroxyprogesterone acetate and Insomnia reports submitted per year:

Could Medroxyprogesterone acetate cause Insomnia?

Time on Medroxyprogesterone acetate when people have Insomnia *:

  • < 1 month: 26.32 %
  • 1 - 6 months: 26.32 %
  • 6 - 12 months: 5.26 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 26.32 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 15.79 %

Gender of people who have Insomnia when taking Medroxyprogesterone acetate *:

  • female: 92.05 %
  • male: 7.95 %

Age of people who have Insomnia when taking Medroxyprogesterone acetate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 2.74 %
  • 20-29: 17.81 %
  • 30-39: 19.18 %
  • 40-49: 12.33 %
  • 50-59: 17.81 %
  • 60+: 30.14 %

Common drugs people take besides Medroxyprogesterone acetate *:

  1. Provera: 21 people, 23.60%
  2. Premarin: 20 people, 22.47%
  3. Prempro: 16 people, 17.98%
  4. Tylenol: 9 people, 10.11%
  5. Estraderm: 9 people, 10.11%
  6. Cycrin: 8 people, 8.99%
  7. Estrace: 8 people, 8.99%
  8. Nasonex: 7 people, 7.87%
  9. Gravol: 7 people, 7.87%
  10. Fosamax: 6 people, 6.74%

Common side effects people have besides Insomnia *:

  1. Depression: 33 people, 37.08%
  2. Fatigue (feeling of tiredness): 25 people, 28.09%
  3. Stress And Anxiety: 23 people, 25.84%
  4. Headache (pain in head): 22 people, 24.72%
  5. Joint Pain: 20 people, 22.47%
  6. Rashes (redness): 17 people, 19.10%
  7. Pain: 17 people, 19.10%
  8. Weight Decreased: 16 people, 17.98%
  9. Tremor (trembling or shaking movements in one or more parts of your body): 14 people, 15.73%
  10. Malaise (a feeling of general discomfort or uneasiness): 14 people, 15.73%

Common conditions people have *:

  1. Menopausal Symptoms: 7 people, 7.87%
  2. Menopause (end of monthly cycles in women): 7 people, 7.87%
  3. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 6.74%
  4. High Blood Pressure: 6 people, 6.74%
  5. Depression: 6 people, 6.74%
  6. Asthma: 4 people, 4.49%
  7. Hair Loss: 4 people, 4.49%
  8. Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 3.37%
  9. Osteoporosis (bones weak and more likely to break): 3 people, 3.37%
  10. Pain: 3 people, 3.37%

* Approximation only. Some reports may have incomplete information.

Do you take Medroxyprogesterone acetate and have Insomnia?

Check whether Insomnia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Insomnia and when was it recovered:

Expand to all the drugs that have ingredients of medroxyprogesterone acetate:

Alternative drugs to, pros and cons of Medroxyprogesterone acetate:

Common Medroxyprogesterone acetate side effects:

Browse all side effects of Medroxyprogesterone acetate:

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Insomnia treatments and more:

COVID vaccines that are related to Insomnia:

Common drugs associated with Insomnia:

All the drugs that are associated with Insomnia:

Common conditions associated with Insomnia:

All the conditions that are associated with Insomnia:

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Medroxyprogesterone acetate) and Medroxyprogesterone acetate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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