Mercaptopurine and Clostridium difficile colitis - a phase IV clinical study of FDA data

• Mercaptopurine (17,983 reports)

• Abdominal distension: 156 reports
• Abdominal pain: 692 reports
• Abdominal pain upper: 182 reports
• Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 135 reports
• Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 186 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 578 reports
• Alanine aminotransferase increased: 286 reports
• Anaemia (lack of blood): 486 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 127 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 196 reports
• Arrhythmias (irregular heartbeat): 209 reports
• Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 174 reports
• Aspartate aminotransferase increased: 180 reports
• Back pain: 259 reports
• Bacterial infection: 407 reports
• Blood bilirubin increased: 166 reports
• Blood pressure fluctuation: 129 reports
• Bone marrow failure: 227 reports
• Breathing difficulty: 399 reports
• Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi): 195 reports
• Cellulitis (infection under the skin): 218 reports
• Chest pain: 237 reports
• Chills (felling of cold): 196 reports
• Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection): 315 reports
• Colitis (inflammation of colon): 239 reports
• Constipation: 235 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 125 reports
• Cough: 310 reports
• Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 906 reports
• Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus): 166 reports
• Cytomegalovirus infection: 109 reports
• Cytomegalovirus viraemia (cytomegalo virus in blood stream): 137 reports
• Death: 326 reports
• Dehydration (dryness resulting from the removal of water): 195 reports
• Depression: 111 reports
• Diarrhea: 762 reports
• Disease progression: 102 reports
• Dizziness: 293 reports
• Drowsiness: 127 reports
• Drug hypersensitivity: 179 reports
• Drug ineffective: 925 reports
• Drug intolerance (drug sensitivity): 130 reports
• Enteritis (inflammation of the small intestine): 152 reports
• Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae): 137 reports
• Fall: 124 reports
• Fatigue (feeling of tiredness): 670 reports
• Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells): 242 reports
• Febrile neutropenia (fever with reduced white blood cells): 1,401 reports
• Fever: 1,229 reports
• Fungal infection: 206 reports
• Gait disturbance: 118 reports
• Haematochezia (passage of stools containing blood): 134 reports
• Haematotoxicity (toxins that destroy red blood cells): 241 reports
• Haemoglobin decreased: 256 reports
• Haemorrhage (bleeding): 115 reports
• Hair loss: 114 reports
• Headache (pain in head): 626 reports
• Head injury: 114 reports
• Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow): 174 reports
• Hepatotoxicity (chemical-driven liver damage): 146 reports
• Herpes zoster: 173 reports
• High blood pressure: 286 reports
• Hyperbilirubinaemia (excess of bilirubin in the blood): 142 reports
• Hyperglycemia (high blood sugar): 116 reports
• Hypersensitivity: 170 reports
• Hypertriglyceridaemia (excess of triglycerides in the blood): 141 reports
• Hypoaesthesia (reduced sense of touch or sensation): 143 reports
• Hypotension (abnormally low blood pressure): 389 reports
• Infection: 220 reports
• Infusion related reaction: 161 reports
• Injection site erythema (redness at injection site): 115 reports
• Injection site pain: 346 reports
• Insomnia (sleeplessness): 108 reports
• Intestinal obstruction: 159 reports
• Itching: 179 reports
• Joint pain: 430 reports
• Leukopenia (less number of white blood cells in blood): 240 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 106 reports
• Malaise (a feeling of general discomfort or uneasiness): 326 reports
• Mucosal inflammation (infection of mucous membrane): 197 reports
• Multi-organ failure (multisystem organ failure): 110 reports
• Muscle aches (muscle pain): 170 reports
• Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 149 reports
• Nasopharyngitis (inflammation of the nasopharynx): 137 reports
• Nausea (feeling of having an urge to vomit): 761 reports
• Nausea and vomiting: 707 reports
• Neuropathy peripheral (surface nerve damage): 180 reports
• Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 130 reports
• Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 177 reports
• Nosebleed (bleeding from nose): 121 reports
• Oedema peripheral (superficial swelling): 101 reports
• Oesophageal candidiasis (fungal infection of oesophagus): 128 reports
• Oral herpes (viral infection of mouth): 115 reports
• Oropharyngeal pain: 133 reports
• Pain: 316 reports
• Pain in extremity: 270 reports
• Pancreatitis (inflammation of pancreas): 334 reports
• Pancreatitis acute (sudden inflammation of pancreas): 133 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 395 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 156 reports
• Parainfluenzae virus infection: 230 reports
• Pleural effusion (water on the lungs): 138 reports
• Pneumatosis intestinalis (air or gas in an intestine): 129 reports
• Pneumonia: 640 reports
• Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas): 171 reports
• Rashes (redness): 462 reports
• Rectal haemorrhage (bleeding from anus): 139 reports
• Renal impairment (severely reduced kidney function): 103 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 171 reports
• Respiratory distress (difficulty in breathing): 128 reports
• Rhinovirus infection: 170 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 177 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 487 reports
• Septic shock (shock due to blood infection): 166 reports
• Sinusitis (inflammation of sinus): 167 reports
• Small intestinal obstruction (blockage in small intestine): 115 reports
• Speech impairment (adult) (inability to speak (adult)): 112 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 122 reports
• Stomatitis (inflammation of mucous membrane of mouth): 165 reports
• Stress and anxiety: 190 reports
• Thrombocytopenia (decrease of platelets in blood): 597 reports
• Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 297 reports
• Upper respiratory tract infection: 160 reports
• Urinary tract infection: 258 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 107 reports
• Venoocclusive liver disease (small veins in the liver are obstructed): 192 reports
• Venous thrombosis (blood clot (thrombus) that forms within a vein): 110 reports
• Viral infection: 300 reports
• Weakness: 471 reports
• Weight decreased: 324 reports
• Weight increased: 234 reports
• White blood cell count decreased: 228 reports

• Clostridium difficile colitis (11,323 reports)

• Accutane: 148 reports
• Acetaminophen: 190 reports
• Acetylsalicylic acid: 149 reports
• Acyclovir: 123 reports
• Albuterol: 224 reports
• Allopurinol: 271 reports
• Alprazolam: 131 reports
• Ambien: 173 reports
• Amlodipine: 261 reports
• Amoxicillin: 262 reports
• Aranesp: 143 reports
• Aredia: 138 reports
• Aspirin: 697 reports
• Atenolol: 135 reports
• Ativan: 230 reports
• Augmentin: 216 reports
• Avelox: 135 reports
• Bactrim: 233 reports
• Benadryl: 161 reports
• Benicar: 267 reports
• Benicar hct: 158 reports
• Calcium: 175 reports
• Carboplatin: 219 reports
• Carvedilol: 119 reports
• Ceftriaxone: 226 reports
• Celexa: 129 reports
• Cipro: 126 reports
• Cisplatin: 149 reports
• Clarithromycin: 105 reports
• Colace: 131 reports
• Coreg: 117 reports
• Coumadin: 232 reports
• Cyclophosphamide: 637 reports
• Cytarabine: 476 reports
• Decadron: 196 reports
• Dexamethasone: 286 reports
• Digoxin: 167 reports
• Dilaudid: 106 reports
• Etoposide: 486 reports
• Famotidine: 102 reports
• Fentanyl: 138 reports
• Fish oil: 114 reports
• Flagyl: 365 reports
• Flonase: 106 reports
• Fluconazole: 214 reports
• Fludara: 169 reports
• Fluorouracil: 112 reports
• Folic acid: 159 reports
• Fosamax: 348 reports
• Furosemide: 420 reports
• Gabapentin: 267 reports
• Heparin: 167 reports
• Humira: 273 reports
• Hydramine: 102 reports
• Hydrochlorothiazide: 194 reports
• Ibu: 132 reports
• Ibuprofen: 132 reports
• Imodium: 127 reports
• Lactulose: 102 reports
• Lansoprazole: 163 reports
• Lantus: 157 reports
• Lasix: 375 reports
• Levaquin: 174 reports
• Lexapro: 131 reports
• Lipitor: 203 reports
• Lisinopril: 344 reports
• Lopressor: 103 reports
• Lopurin: 318 reports
• Loraz: 205 reports
• Lorazepam: 204 reports
• Lovenox: 131 reports
• Lyrica: 136 reports
• Magnesium: 141 reports
• Mercaptopurine: 315 reports
• Meropenem: 257 reports
• Metformin: 244 reports
• Methotrexate: 688 reports
• Metoclopramide: 113 reports
• Metoprolol tartrate: 164 reports
• Metronidazole: 531 reports
• Morphine: 285 reports
• Multivitamin: 130 reports
• Mycophenolate mofetil: 260 reports
• Neupogen: 127 reports
• Neurontin: 162 reports
• Nexium: 281 reports
• Norvasc: 155 reports
• Nystatin: 115 reports
• Omeprazole: 542 reports
• Ondansetron: 233 reports
• Oxycodone: 213 reports
• Oxycontin: 162 reports
• Paclitaxel: 108 reports
• Pantoprazole: 417 reports
• Paracetamol: 123 reports
• Paxil: 115 reports
• Pepcid: 130 reports
• Percocet: 173 reports
• Phenergan: 119 reports
• Plavix: 142 reports
• Prednisolone: 293 reports
• Prednisone: 1,105 reports
• Prevacid: 147 reports
• Prilosec: 188 reports
• Profen: 132 reports
• Protonix: 299 reports
• Ramipril: 139 reports
• Remicade: 147 reports
• Revlimid: 455 reports
• Rocephin: 114 reports
• Sertraline: 117 reports
• Simvastatin: 287 reports
• Spiriva: 147 reports
• Spironolactone: 140 reports
• Synthroid: 214 reports
• Tacrolimus: 308 reports
• Tramadol: 178 reports
• Tylenol: 286 reports
• Tysabri: 167 reports
• Velcade: 234 reports
• Vincristine sulfate: 235 reports
• Vitamin d: 223 reports
• Vitamins: 152 reports
• Xanax: 158 reports
• Xarelto: 101 reports
• Zide: 184 reports
• Zocor: 117 reports
• Zofran: 280 reports
• Zoloft: 154 reports
• Zometa: 241 reports

All the drugs that are associated with Clostridium difficile colitis:

• Clostridium difficile colitis (1,907 drugs)

• Acid reflux: 245 reports
• Acupuncture and pain: 316 reports
• Acute childhood leukemia: 348 reports
• Acute lymphoblastic anemia: 348 reports
• Acute lymphoblastic leukemia: 348 reports
• Acute lymphocytic leukaemia: 348 reports
• Acute lymphocytic leukemia: 348 reports
• Acute lymphocytic leukemia (all): 348 reports
• Acute myeloid leukaemia: 171 reports
• Adult hypothyroidism: 122 reports
• A-fib: 232 reports
• All: 348 reports
• Antidepressant therapy: 285 reports
• Anxiety: 191 reports
• Anxiety and stress: 191 reports
• Atrial fibrillation: 228 reports
• Atrial fibrillation/flutter: 228 reports
• Atrial flutter: 228 reports
• Auricular fibrillation: 228 reports
• Bladder infection: 324 reports
• Blood cholesterol abnormal: 183 reports
• Blood cholesterol increased: 183 reports
• Blood pressure increased: 678 reports
• Blood triglycerides abnormal: 180 reports
• Blood triglycerides increased: 191 reports
• Bronchopneumonia: 240 reports
• Cancer - acute childhood leukemia (all): 348 reports
• Cdf/cdf: 187 reports
• C. diff: 187 reports
• C. difficile: 187 reports
• C. difficile colitis: 178 reports
• Chronic obstructive airway disease: 133 reports
• Chronic obstructive pulmonary disease: 133 reports
• Clostridium difficile: 187 reports
• Clostridium difficile colitis: 187 reports
• Colitis ulcerative: 202 reports
• Community-acquired pneumonia: 240 reports
• Copd: 133 reports
• Crohn's disease: 326 reports
• Crohns disease: 326 reports
• Crohn's disease aggravated: 326 reports
• Cystitis: 315 reports
• Depression: 285 reports
• Diabetes: 167 reports
• Diabetes mellitus: 165 reports
• Diabetes mellitus management: 167 reports
• Diarrhea: 185 reports
• Diarrhoea: 185 reports
• Diffuse large b-cell lymphoma: 118 reports
• Dm: 167 reports
• Dyslipidemia: 183 reports
• Feeling uptight: 191 reports
• Gastroesophageal reflux disease: 245 reports
• Gastrooesophageal reflux disease: 265 reports
• Gerd: 245 reports
• Gerds: 245 reports
• Glucose test: 156 reports
• Granulomatous ileocolitis: 326 reports
• Hbp: 678 reports
• Heartburn: 245 reports
• Heartburn - chronic: 245 reports
• Heart fibrillation: 228 reports
• High blood cholesterol: 183 reports
• High blood pressure: 678 reports
• Htn: 678 reports
• Hypercholesterolaemia: 180 reports
• Hyperlipidemia: 183 reports
• Hypertension: 678 reports
• Hypothyroid: 122 reports
• Hypothyroidism: 122 reports
• Ileitis: 299 reports
• Infection: 181 reports
• Inflammatory bowel disease - ulcerative colitis: 220 reports
• Insomnia: 120 reports
• Insomnia concerns: 127 reports
• Insomnia exacerbated: 120 reports
• Insomnolence: 120 reports
• Jitters: 191 reports
• Lipid profile: 113 reports
• Lipoprotein test: 183 reports
• Loose bowel movements: 185 reports
• Low thyroid: 122 reports
• Malignant plasmacytoma: 638 reports
• Ms: 311 reports
• Ms hug: 311 reports
• Multiple myeloma: 698 reports
• Multiple sclerosis: 311 reports
• Myxedema: 122 reports
• Nausea: 172 reports
• Niddm: 113 reports
• Non-hodgkin's lymphoma: 118 reports
• Osteoporosis: 309 reports
• Pain: 430 reports
• Pain management: 430 reports
• Pain relief: 430 reports
• Plasma cell dyscrasia: 638 reports
• Plasma cell myeloma: 622 reports
• Plasmacytoma of bone: 638 reports
• Pneumonia: 240 reports
• Pneumonitis: 240 reports
• Preventive health care: 216 reports
• Primary pulmonary hypertension: 186 reports
• Pulmonary arterial hypertension: 186 reports
• Ra: 285 reports
• Regional enteritis: 326 reports
• Rheumatoid arthritis: 285 reports
• Sleep aid: 120 reports
• Sleeping: 120 reports
• Sleeping difficulty: 120 reports
• Sleep issues: 120 reports
• Stress: 191 reports
• Stress and anxiety: 191 reports
• Tension: 191 reports
• Thin bones: 299 reports
• Thrombosis: 110 reports
• Type 2 diabetes: 113 reports
• Uc: 220 reports
• Ulcerative colitis: 220 reports
• Under active thyroids: 122 reports
• Urinary tract infection: 324 reports
• Uti: 338 reports

All the conditions that are associated with Clostridium difficile colitis:

• Clostridium difficile colitis (1,583 conditions)

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