Metformin and Depressed mood - a phase IV clinical study of FDA data
Summary:
Depressed mood is found among people who take Metformin, especially for people who are female, 60+ old, have been taking the drug for 10+ years.
The phase IV clinical study analyzes which people take Metformin and have Depressed mood. It is created by eHealthMe based on reports of 363,447 people who have side effects when taking Metformin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.
On Jun, 05, 2022
363,447 people reported to have side effects when taking Metformin.
Among them, 1,197 people (0.33%) have Depressed mood.
What is Metformin?
Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 373,350 Metformin users for its effectiveness, alternative drugs and more.
What is Depressed mood?
Depressed mood is found to be associated with 1,993 drugs and 1,496 conditions by eHealthMe.
Number of Metformin and Depressed mood reports submitted per year:
Time on Metformin when people have Depressed mood *:
Gender of people who have Depressed mood when taking Metformin*:
Age of people who have Depressed mood when taking Metformin *:
Common drugs people take besides Metformin *:
Common side effects people have besides Depressed mood *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Metformin and have Depressed mood?
Check whether Depressed mood is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
Related studies
Alternative drugs to, pros and cons of Metformin:
- Metformin (373,350 reports)
Depressed mood treatments and more:
- Depressed mood (51,429 reports)
COVID vaccines that are related to Depressed mood:
- Depressed mood in Moderna COVID Vaccine
- Depressed mood in Pfizer BioNTech Covid Vaccine
- Depressed mood in Johnson and Johnson Covid Vaccine
How severe was Depressed mood and when was it recovered:
Expand to all the drugs that have ingredients of metformin hydrochloride:
Common drugs associated with Depressed mood:
- Abilify: 460 reports
- Accutane: 317 reports
- Acetaminophen: 171 reports
- Acetylsalicylic acid: 491 reports
- Actonel: 121 reports
- Adderall: 325 reports
- Advair diskus 100/50: 118 reports
- Advair hfa: 189 reports
- Advil: 247 reports
- Afinitor: 113 reports
- Albuterol: 406 reports
- Aleve: 148 reports
- Allegra: 179 reports
- Alli: 103 reports
- Allopurinol: 286 reports
- Alprazolam: 421 reports
- Ambien: 439 reports
- Amlodipine: 868 reports
- Amlodipine besylate: 118 reports
- Amoxicillin: 304 reports
- Ampyra: 593 reports
- Anastrozole: 109 reports
- Androgel: 126 reports
- Arava: 112 reports
- Aredia: 148 reports
- Aripiprazole: 259 reports
- Asa: 120 reports
- Aspirin: 1,413 reports
- Atenolol: 573 reports
- Ativan: 376 reports
- Atorvastatin calcium: 176 reports
- Atrovent: 121 reports
- Aubagio: 526 reports
- Avonex: 892 reports
- Azathioprine: 104 reports
- Baclofen: 478 reports
- Benadryl: 298 reports
- Benlysta: 114 reports
- Betaseron: 224 reports
- Biotin: 183 reports
- Bisoprolol fumarate: 136 reports
- Bupropion hydrochloride: 118 reports
- Buspar: 118 reports
- Byetta: 145 reports
- Calcium: 525 reports
- Carbamazepine: 268 reports
- Carboplatin: 109 reports
- Carvedilol: 199 reports
- Celebrex: 384 reports
- Celexa: 298 reports
- Centrum: 142 reports
- Cephalexin: 124 reports
- Cetirizine hydrochloride: 167 reports
- Chantix: 1,238 reports
- Cialis: 340 reports
- Citalopram hydrobromide: 240 reports
- Clarithromycin: 108 reports
- Claritin: 190 reports
- Clonazepam: 877 reports
- Clonidine: 200 reports
- Clopidogrel: 210 reports
- Clozapine: 203 reports
- Clozaril: 122 reports
- Codeine: 177 reports
- Colace: 141 reports
- Combivent: 158 reports
- Concerta: 161 reports
- Copaxone: 185 reports
- Copegus: 106 reports
- Cosentyx: 322 reports
- Coumadin: 226 reports
- Crestor: 297 reports
- Cymbalta: 1,708 reports
- Decadron: 110 reports
- Depakote: 263 reports
- Depo-provera: 106 reports
- Dexamethasone: 170 reports
- Diazepam: 741 reports
- Diclofenac: 118 reports
- Digoxin: 147 reports
- Dilaudid: 249 reports
- Diovan: 213 reports
- Doxycycline: 255 reports
- Duloxetine hydrochloride: 112 reports
- Effexor: 900 reports
- Effexor xr: 421 reports
- Eliquis: 140 reports
- Enbrel: 921 reports
- Entresto: 228 reports
- Ergocalciferol: 224 reports
- Esbriet: 122 reports
- Escitalopram: 459 reports
- Femara: 140 reports
- Fentanyl: 139 reports
- Finasteride: 153 reports
- Fish oil: 454 reports
- Flexeril: 181 reports
- Flomax: 103 reports
- Flonase: 221 reports
- Flovent: 125 reports
- Fluconazole: 109 reports
- Fluoxetine: 845 reports
- Fluticasone propionate: 101 reports
- Folic acid: 212 reports
- Forteo: 351 reports
- Fosamax: 160 reports
- Furosemide: 612 reports
- Gabapentin: 1,101 reports
- Geodon: 116 reports
- Gilenya: 1,086 reports
- Glipizide: 161 reports
- Glucophage: 108 reports
- Herceptin: 133 reports
- Humalog: 259 reports
- Humira: 1,433 reports
- Hydrochlorothiazide: 443 reports
- Hydrocodone bitartrate and acetaminophen: 136 reports
- Hydroxyzine: 153 reports
- Ibrance: 239 reports
- Ibu: 829 reports
- Ibuprofen: 767 reports
- Imbruvica: 170 reports
- Imodium: 104 reports
- Insulin: 215 reports
- Jakafi: 183 reports
- Januvia: 113 reports
- Keflex: 120 reports
- Keppra: 233 reports
- Klonopin: 456 reports
- Lactulose: 179 reports
- Lamictal: 369 reports
- Lamotrigine: 480 reports
- Lansoprazole: 344 reports
- Lantus: 300 reports
- Lasix: 370 reports
- Latuda: 240 reports
- Leflunomide: 116 reports
- Letrozole: 201 reports
- Levaquin: 112 reports
- Levetiracetam: 281 reports
- Levothyroxine sodium: 445 reports
- Levoxyl: 103 reports
- Lexapro: 461 reports
- Lipitor: 512 reports
- Lisinopril: 779 reports
- Lithium carbonate: 155 reports
- Loratadine: 191 reports
- Loraz: 714 reports
- Lorazepam: 755 reports
- Lortab: 126 reports
- Losartan: 630 reports
- Losartan potassium: 145 reports
- Lupron: 213 reports
- Lupron depot: 136 reports
- Lyrica: 1,109 reports
- Magnesium: 339 reports
- Meclizine: 105 reports
- Medrol: 111 reports
- Melatonin: 213 reports
- Meloxicam: 246 reports
- Metformin: 1,197 reports
- Metformin hydrochloride: 121 reports
- Methotrexate: 879 reports
- Methotrexate sodium: 144 reports
- Metoclopramide: 266 reports
- Metoprolol succinate: 131 reports
- Metoprolol tartrate: 170 reports
- Metronidazole: 199 reports
- Miralax: 161 reports
- Mirena: 954 reports
- Mirtazapine: 646 reports
- Modafinil: 103 reports
- Montelukast sodium: 111 reports
- Morphine: 473 reports
- Morphine sulfate: 235 reports
- Motrin: 131 reports
- Multivitamin: 303 reports
- Myorisan: 213 reports
- Naproxen: 255 reports
- Nasonex: 118 reports
- Neurontin: 502 reports
- Nexium: 439 reports
- Nexplanon: 183 reports
- Nicotine: 126 reports
- Norco: 167 reports
- Norvasc: 233 reports
- Novothyrox: 400 reports
- Nuvigil: 123 reports
- Nystatin: 130 reports
- Olanzapine: 370 reports
- Omeprazole: 1,203 reports
- Ondansetron: 284 reports
- Opsumit: 194 reports
- Otezla: 377 reports
- Oxycodone: 327 reports
- Oxycontin: 410 reports
- Paclitaxel: 117 reports
- Pantoprazole: 682 reports
- Paracetamol: 518 reports
- Paroxetine: 875 reports
- Paroxetine hydrochloride: 231 reports
- Paxil: 569 reports
- Pegasys: 330 reports
- Peginterferon: 133 reports
- Percocet: 332 reports
- Phenergan: 107 reports
- Plaquenil: 210 reports
- Plavix: 264 reports
- Potassium: 128 reports
- Prednisolone: 297 reports
- Prednisone: 1,366 reports
- Pregabalin: 339 reports
- Premarin: 198 reports
- Prevacid: 284 reports
- Prilosec: 323 reports
- Pristiq: 208 reports
- Proair hfa: 133 reports
- Probiotic: 131 reports
- Progesterone: 107 reports
- Prolia: 134 reports
- Protonix: 255 reports
- Provera: 144 reports
- Provigil: 168 reports
- Prozac: 610 reports
- Q10: 114 reports
- Quetiapine fumarate: 119 reports
- Ramipril: 520 reports
- Ranitidine: 238 reports
- Rebif: 379 reports
- Remeron: 149 reports
- Remicade: 146 reports
- Remodulin: 104 reports
- Repatha: 102 reports
- Requip: 122 reports
- Revlimid: 153 reports
- Ribavirin: 477 reports
- Risperdal: 264 reports
- Risperidone: 288 reports
- Ritalin: 270 reports
- Rituxan: 107 reports
- Sandostatin: 582 reports
- Sandostatin lar: 517 reports
- Senna: 141 reports
- Seroquel: 759 reports
- Sertraline: 935 reports
- Sertraline hydrochloride: 167 reports
- Simvastatin: 743 reports
- Sinemet: 132 reports
- Singulair: 544 reports
- Soliris: 143 reports
- Spiriva: 282 reports
- Spironolactone: 297 reports
- Stelara: 102 reports
- Strattera: 314 reports
- Suboxone: 128 reports
- Sulfasalazine: 129 reports
- Sutent: 156 reports
- Symbicort: 261 reports
- Synthroid: 730 reports
- Tamsulosin: 170 reports
- Tasigna: 128 reports
- Taxotere: 140 reports
- Tecfidera: 605 reports
- Tegretol: 176 reports
- Temazepam: 227 reports
- Theophylline: 101 reports
- Topamax: 237 reports
- Topiramate: 241 reports
- Toprol-xl: 111 reports
- Tramadol: 835 reports
- Trazodone hydrochloride: 110 reports
- Trileptal: 125 reports
- Truvada: 101 reports
- Tylenol: 574 reports
- Tysabri: 1,073 reports
- Ultram: 110 reports
- Valium: 247 reports
- Valproic acid: 219 reports
- Valsartan: 151 reports
- Venlafaxine hydrochloride: 109 reports
- Ventolin: 221 reports
- Vicodin: 224 reports
- Vioxx: 168 reports
- Vitamin b12: 564 reports
- Vitamin c: 308 reports
- Vitamin d: 1,246 reports
- Vitamin d3: 389 reports
- Vitamin e: 169 reports
- Vitamins: 397 reports
- Vivitrol: 205 reports
- Voltaren: 120 reports
- Vyvanse: 271 reports
- Warfarin sodium: 118 reports
- Wellbutrin: 670 reports
- Wellbutrin xl: 147 reports
- Xanax: 750 reports
- Xarelto: 151 reports
- Xeljanz: 1,420 reports
- Xeljanz xr: 842 reports
- Xolair: 251 reports
- Xyrem: 256 reports
- Yasmin: 150 reports
- Zantac: 161 reports
- Zocor: 220 reports
- Zofran: 251 reports
- Zoloft: 876 reports
- Zolpidem: 388 reports
- Zolpidem tartrate: 111 reports
- Zometa: 296 reports
- Zopiclone: 449 reports
- Zyprexa: 238 reports
- Zyrtec: 285 reports
All the drugs that are associated with Depressed mood:
- Depressed mood (1,993 drugs)
Common conditions associated with Depressed mood:
- Acid reflux: 343 reports
- Acne: 470 reports
- Acne aggravated: 482 reports
- Acne vulgaris: 457 reports
- Acromegaly: 207 reports
- Add: 822 reports
- Adhd: 822 reports
- Adult hypothyroidism: 578 reports
- Ankylosing spondylitis: 222 reports
- Antidepressant therapy: 3,383 reports
- Anxiety: 1,503 reports
- Anxiety and stress: 1,447 reports
- Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 1,447 reports
- Arthralgia: 120 reports
- Arthritis: 189 reports
- Arthritis - rheumatoid: 2,021 reports
- Asthma: 782 reports
- Atrial fibrillation: 162 reports
- Atrial fibrillation/flutter: 162 reports
- Attention deficit disorder with hyperactivity: 843 reports
- Attention deficit hyperactivity disorder: 822 reports
- Attention deficit/hyperactivity disorder: 574 reports
- Attention deficit hyperactivity disorder (adhd): 822 reports
- Back pain: 348 reports
- Back pain - nonspecific: 348 reports
- Bipolar: 643 reports
- Bi-polar: 643 reports
- Bipolar 1: 127 reports
- Bipolar disorder: 643 reports
- Bipolar i disorder: 133 reports
- Birth control: 1,154 reports
- Birth control and family planning: 1,154 reports
- Blood cholesterol abnormal: 885 reports
- Blood cholesterol increased: 844 reports
- Blood pressure abnormal: 264 reports
- Blood pressure - high: 1,715 reports
- Blood pressure management: 191 reports
- Blood triglycerides abnormal: 885 reports
- Blood triglycerides increased: 885 reports
- Breast cancer: 371 reports
- Breast cancer metastatic: 213 reports
- Bronchial asthma: 776 reports
- Cancer - breast: 371 reports
- Cancer - ovaries: 132 reports
- Cancer - prostate: 173 reports
- Cannot sleep: 671 reports
- Carcinoma - lobular: 371 reports
- Cardiac failure: 110 reports
- Cessation of smoking: 1,338 reports
- Childhood hyperkinesis: 822 reports
- Chronic asthma: 776 reports
- Chronic lymphocytic leukaemia: 147 reports
- Chronic myeloid leukaemia: 208 reports
- Chronic obstructive pulmonary disease: 218 reports
- Colitis ulcerative: 333 reports
- Constipation: 198 reports
- Constipation aggravated: 198 reports
- Contraception: 1,178 reports
- Convulsion: 109 reports
- Copd: 209 reports
- Cough: 102 reports
- Crohn's disease: 620 reports
- Crohns disease: 620 reports
- Cystitis: 185 reports
- Depressed mood: 118 reports
- Depression: 3,485 reports
- Depression - major: 301 reports
- Diabetes: 646 reports
- Diabetes mellitus: 701 reports
- Diabetes mellitus management: 701 reports
- Diabetes mellitus non-insulin-dependent: 229 reports
- Diabetes - type 2: 374 reports
- Difficulty falling asleep: 671 reports
- Drugs that may cause impotence: 348 reports
- Dyspepsia: 138 reports
- Dyssomnia: 671 reports
- Ed: 360 reports
- Endometriosis: 103 reports
- Epilepsy: 364 reports
- Erectile disturbance: 361 reports
- Erectile dysfunction: 360 reports
- Erection problems: 360 reports
- Fibromyalgia: 361 reports
- Fibromyalgia syndrome: 361 reports
- Fibrositis: 377 reports
- Gait disturbance: 187 reports
- Gastritis: 125 reports
- Gastroesophageal reflux disease: 343 reports
- Gastrooesophageal reflux disease: 343 reports
- Gerd: 374 reports
- Glaucoma: 144 reports
- Hair thinning: 114 reports
- Hbp: 1,608 reports
- Headache: 251 reports
- Headaches: 251 reports
- Heartburn: 343 reports
- Heavy or prolong menstrual bleeding: 162 reports
- Hepatitis c: 626 reports
- High blood cholesterol: 844 reports
- High blood cholesterol and triglycerides: 844 reports
- High blood pressure: 1,715 reports
- High cholesterol: 844 reports
- Hiv: 255 reports
- Hiv infection: 257 reports
- Hormone replacement therapy: 144 reports
- Human immunodeficiency virus infection: 255 reports
- Hypercholesterolaemia: 844 reports
- Hypercholesterolemia: 844 reports
- Hyperlipidemia: 844 reports
- Hypersensitivity: 241 reports
- Hypertension: 1,716 reports
- Hypothyroid: 578 reports
- Hypothyroidism: 578 reports
- Hypothyroids: 578 reports
- Idiopathic pulmonary fibrosis: 173 reports
- Ileitis: 620 reports
- Indigestion: 168 reports
- Inflammatory bowel disease - crohn's disease: 620 reports
- Inflammatory bowel disease - ulcerative colitis: 435 reports
- Insomnia: 694 reports
- Insomnia concerns: 671 reports
- Joint pain: 120 reports
- Lack of regular bowel movements: 229 reports
- Lipid test: 885 reports
- Low thyroid: 628 reports
- Lupus erythematosus: 140 reports
- Major depression: 301 reports
- Major depressive disorder: 303 reports
- Migraine: 297 reports
- Migraines: 296 reports
- Ms: 4,572 reports
- Ms hug: 4,572 reports
- Multiple allergies: 110 reports
- Multiple myeloma: 250 reports
- Multiple sclerosis: 4,572 reports
- Muscle spasm: 130 reports
- Muscle spasms: 130 reports
- Myofascial pain syndrome: 361 reports
- Myxedema: 578 reports
- Narcolepsy: 248 reports
- Nausea: 282 reports
- Nerve pain: 290 reports
- Neuralgia: 291 reports
- Neuropathy peripheral: 223 reports
- Obsessive-compulsive disorder: 139 reports
- Ocd: 139 reports
- Osteoporosis: 663 reports
- Ovarian cancer: 132 reports
- Pain: 1,551 reports
- Pain - head: 251 reports
- Pain management: 1,549 reports
- Pain relief: 1,549 reports
- Pain relief by acupuncture: 1,549 reports
- Panic attack: 187 reports
- Panic attacks: 187 reports
- Panic disorder: 187 reports
- Parkinson's disease: 629 reports
- Post traumatic stress disorder: 106 reports
- Post-traumatic stress disorder: 103 reports
- Pregnancy: 1,154 reports
- Preventive health care: 168 reports
- Primary myelofibrosis: 196 reports
- Primary pulmonary hypertension: 416 reports
- Prostate cancer: 173 reports
- Psoriasis: 661 reports
- Psoriatic arthropathy: 541 reports
- Ptsd: 103 reports
- Quit smoking: 1,345 reports
- Ra: 2,021 reports
- Reflux: 343 reports
- Relapsing-remitting multiple sclerosis: 397 reports
- Restless legs syndrome: 129 reports
- Restless leg syndrome: 129 reports
- Rheumatoid arthritis: 2,021 reports
- Rls: 157 reports
- Rrms: 354 reports
- Schizophrenia: 401 reports
- Seizures: 177 reports
- Sleep aid: 694 reports
- Sleep disorder: 592 reports
- Sleep disorder due to general medical condition, insomnia type: 592 reports
- Sleep disorder therapy: 592 reports
- Sleep issues: 671 reports
- Sleeplessness: 671 reports
- Smoking and smokeless tobacco: 1,338 reports
- Smoking cessation: 1,338 reports
- Smoking cessation therapy: 1,338 reports
- Spondylitis: 222 reports
- Sporadic primary pulmonary hypertension: 445 reports
- Stop smoking: 1,338 reports
- Stress: 1,502 reports
- Stress and anxiety: 1,502 reports
- Systemic lupus erythematosus: 140 reports
- Tension: 1,447 reports
- Thyroid diseases: 287 reports
- Thyroid disorder: 287 reports
- Thyroid function test abnormal: 287 reports
- Tobacco abuse: 1,338 reports
- Tobacco user: 1,338 reports
- Type 2 diabetes: 374 reports
- Type 2 diabetes mellitus: 403 reports
- Uc: 435 reports
- Ulcerative colitis: 333 reports
- Underactive thyroid: 578 reports
- Urinary tract infection: 185 reports
- Uti: 185 reports
All the conditions that are associated with Depressed mood:
- Depressed mood (1,496 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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