Metformin and Hyporesponsive to stimuli - a phase IV clinical study of FDA data


Hyporesponsive to stimuli is found among people who take Metformin, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months.

The phase IV clinical study analyzes which people take Metformin and have Hyporesponsive to stimuli. It is created by eHealthMe based on reports of 395,495 people who have side effects when taking Metformin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

395,495 people reported to have side effects when taking Metformin.
Among them, 38 people (0.01%) have Hyporesponsive to stimuli.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 405,808 Metformin users for its effectiveness, alternative drugs and more.

What is Hyporesponsive to stimuli?

Hyporesponsive to stimuli (abnormally low degree of responsiveness on an agent, action, or condition) is found to be associated with 355 drugs and 178 conditions by eHealthMe.

Number of Metformin and Hyporesponsive to stimuli reports submitted per year:

Could Metformin cause Hyporesponsive to stimuli?

Time on Metformin when people have Hyporesponsive to stimuli *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hyporesponsive to stimuli when taking Metformin *:

  • female: 75.68 %
  • male: 24.32 %

Age of people who have Hyporesponsive to stimuli when taking Metformin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 5.41 %
  • 50-59: 29.73 %
  • 60+: 64.86 %

Common drugs people take besides Metformin *:

  1. Lasix: 8 people, 21.05%
  2. Ampicillin And Sulbactam: 6 people, 15.79%
  3. Amlodipine: 4 people, 10.53%
  4. Furosemide: 2 people, 5.26%
  5. Sertraline: 2 people, 5.26%
  6. Oxycodone: 2 people, 5.26%
  7. Clopidogrel: 2 people, 5.26%
  8. Lantus: 2 people, 5.26%
  9. Senna: 2 people, 5.26%
  10. Sinemet: 2 people, 5.26%

Common side effects people have besides Hyporesponsive to stimuli *:

  1. Fever: 14 people, 36.84%
  2. Hypotension (abnormally low blood pressure): 10 people, 26.32%
  3. Confusional State: 10 people, 26.32%
  4. Abnormal Behavior: 10 people, 26.32%
  5. Hypoglycemia (low blood sugar): 10 people, 26.32%
  6. Dermatitis Bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid): 9 people, 23.68%
  7. Normochromic Normocytic Anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits): 9 people, 23.68%
  8. Oedema (fluid collection in tissue): 9 people, 23.68%
  9. Purpura (purplish discoloration of the skin): 9 people, 23.68%
  10. Necrosis (the death of body tissue): 8 people, 21.05%

Common conditions people have *:

  1. Meningitis Bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 9 people, 23.68%
  2. Cardiac Failure: 9 people, 23.68%
  3. Upper Respiratory Tract Infection: 8 people, 21.05%
  4. Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 3 people, 7.89%
  5. Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 5.26%
  6. Rashes (redness): 2 people, 5.26%
  7. Parkinson's Disease: 2 people, 5.26%
  8. Hypoglycemia (low blood sugar): 2 people, 5.26%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 5.26%
  10. Type 1 Diabetes: 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Hyporesponsive to stimuli?

Check whether Hyporesponsive to stimuli is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Hyporesponsive to stimuli and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Alternative drugs to, pros and cons of Metformin:

Common Metformin side effects:

Browse all side effects of Metformin:

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Hyporesponsive to stimuli treatments and more:

COVID vaccines that are related to Hyporesponsive to stimuli:

All the drugs that are associated with Hyporesponsive to stimuli:

All the conditions that are associated with Hyporesponsive to stimuli:

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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