Metformin and Memory loss - a phase IV clinical study of FDA data
Summary:
We study 429,842 people who have side effects when taking Metformin. Memory loss is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Lyrica and have High blood pressure.
The phase IV clinical study analyzes which people take Metformin and have Memory loss. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
429,842 people reported to have side effects when taking Metformin.
Among them, 5,864 people (1.36%) have Memory loss.
What is Metformin?
Metformin has active ingredients of metformin hydrochloride. It is used in diabetes. Currently, eHealthMe is studying from 440,945 Metformin users.
What is Memory loss?
Memory loss is found to be associated with 3,986 drugs and 4,279 conditions by eHealthMe. Currently, we are studying 231,925 people who have Memory loss.
Number of Metformin and Memory loss reports submitted per year:

Time on Metformin when people have Memory loss *:
Gender of people who have Memory loss when taking Metformin*:
Age of people who have Memory loss when taking Metformin *:
Common drugs people take besides Metformin *:
Common side effects people have besides Memory loss *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Metformin and have Memory loss?
Check whether Memory loss is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
Related studies
Metformin side effects by duration, gender and age:
- Metformin side effects (440,945 reports)
Memory loss treatments and more:
- Memory loss (231,925 reports)
Common drugs associated with Memory loss:
- Tysabri: 11,420 reports
- Avonex: 10,093 reports
- Aspirin: 9,906 reports
- Lyrica: 9,006 reports
- Gabapentin: 7,466 reports
- Tecfidera: 7,103 reports
- Prednisone: 6,787 reports
- Vitamin d: 6,636 reports
- Omeprazole: 6,243 reports
- Humira: 5,900 reports
All the drugs that are associated with Memory loss:
- Memory loss (3,986 drugs)
Common conditions associated with Memory loss:
- Multiple sclerosis: 36,572 reports
- Rheumatoid arthritis: 10,704 reports
- Depression: 10,082 reports
- Pain: 9,344 reports
All the conditions that are associated with Memory loss:
- Memory loss (4,279 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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