Methadone hydrochloride and Gingival disorder - a phase IV clinical study of FDA data


Gingival disorder is found among people who take Methadone hydrochloride, especially for people who are male, 40-49 old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Methadone hydrochloride and have Gingival disorder. It is created by eHealthMe based on reports of 5,090 people who have side effects when taking Methadone hydrochloride from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

5,090 people reported to have side effects when taking Methadone hydrochloride.
Among them, 7 people (0.14%) have Gingival disorder.

What is Methadone hydrochloride?

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 6,940 Methadone hydrochloride users for its effectiveness, alternative drugs and more.

What is Gingival disorder?

Gingival disorder (gum disease) is found to be associated with 1,036 drugs and 528 conditions by eHealthMe.

Number of Methadone hydrochloride and Gingival disorder reports submitted per year:

Could Methadone hydrochloride cause Gingival disorder?

Time on Methadone hydrochloride when people have Gingival disorder *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Gingival disorder when taking Methadone hydrochloride *:

  • female: 14.29 %
  • male: 85.71 %

Age of people who have Gingival disorder when taking Methadone hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 100 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Methadone hydrochloride *:

  1. Celebrex: 6 people, 85.71%
  2. Zometa: 5 people, 71.43%
  3. Dulcolax: 5 people, 71.43%
  4. Ibuprofen: 5 people, 71.43%
  5. Zofran: 5 people, 71.43%
  6. Gemzar: 5 people, 71.43%
  7. Fluorouracil: 5 people, 71.43%
  8. Elavil: 5 people, 71.43%
  9. Effexor Xr: 5 people, 71.43%
  10. Decadron: 5 people, 71.43%

Common side effects people have besides Gingival disorder *:

  1. Hypoaesthesia (reduced sense of touch or sensation): 7 people, 100.00%
  2. Fever: 6 people, 85.71%
  3. Muscle Spasms (muscle contraction): 6 people, 85.71%
  4. Weight Decreased: 6 people, 85.71%
  5. Fall: 6 people, 85.71%
  6. Depression: 6 people, 85.71%
  7. Injury: 6 people, 85.71%
  8. Limb Discomfort (discomfort in leg): 5 people, 71.43%
  9. Lobar Pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung): 5 people, 71.43%
  10. Malnutrition (condition that results from eating a diet in which certain nutrients are lacking): 5 people, 71.43%

Common conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 1 person, 14.29%
  2. Migraine (headache): 1 person, 14.29%
  3. Insomnia (sleeplessness): 1 person, 14.29%
  4. Ill-Defined Disorder: 1 person, 14.29%
  5. Back Pain: 1 person, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Methadone hydrochloride and have Gingival disorder?

Check whether Gingival disorder is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Gingival disorder and when was it recovered:

Expand to all the drugs that have ingredients of methadone hydrochloride:

Alternative drugs to, pros and cons of Methadone hydrochloride:

Common Methadone hydrochloride side effects:

Browse all side effects of Methadone hydrochloride:

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Gingival disorder treatments and more:

COVID vaccines that are related to Gingival disorder:

Common drugs associated with Gingival disorder:

All the drugs that are associated with Gingival disorder:

Common conditions associated with Gingival disorder:

All the conditions that are associated with Gingival disorder:

How the study uses the data?

The study uses data from the FDA. It is based on methadone hydrochloride (the active ingredients of Methadone hydrochloride) and Methadone hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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