Methotrexate sodium and Acute pulmonary histoplasmosis - a phase IV clinical study of FDA data


Acute pulmonary histoplasmosis is found among people who take Methotrexate sodium, especially for people who are male, 20-29 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Methotrexate sodium and have Acute pulmonary histoplasmosis. It is created by eHealthMe based on reports of 89,800 people who have side effects when taking Methotrexate sodium from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 18, 2023

89,800 people reported to have side effects when taking Methotrexate sodium.
Among them, 6 people (0.01%) have Acute pulmonary histoplasmosis.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 91,108 Methotrexate sodium users for its effectiveness, alternative drugs and more.

What is Acute pulmonary histoplasmosis?

Acute pulmonary histoplasmosis (acute infection by inhalation of spores of the fungus histoplasma capsulatum) is found to be associated with 153 drugs and 80 conditions by eHealthMe.

Number of Methotrexate sodium and Acute pulmonary histoplasmosis reports submitted per year:

Could Methotrexate sodium cause Acute pulmonary histoplasmosis?

Time on Methotrexate sodium when people have Acute pulmonary histoplasmosis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Acute pulmonary histoplasmosis when taking Methotrexate sodium *:

  • female: 50 %
  • male: 50 %

Age of people who have Acute pulmonary histoplasmosis when taking Methotrexate sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 20 %
  • 20-29: 40 %
  • 30-39: 20 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 20 %

Common drugs people take besides Methotrexate sodium *:

  1. Zoloft: 1 person, 16.67%
  2. Tramadol: 1 person, 16.67%
  3. Protonix: 1 person, 16.67%
  4. Nexplanon: 1 person, 16.67%
  5. Ilaris: 1 person, 16.67%
  6. Humira: 1 person, 16.67%
  7. Folic Acid: 1 person, 16.67%
  8. Fioricet: 1 person, 16.67%
  9. Enbrel: 1 person, 16.67%
  10. Cymbalta: 1 person, 16.67%

Common side effects people have besides Acute pulmonary histoplasmosis *:

  1. Cough: 2 people, 33.33%
  2. Septic Shock (shock due to blood infection): 1 person, 16.67%
  3. Pneumonia: 1 person, 16.67%
  4. Abdominal Pain: 1 person, 16.67%
  5. Bleeding Disorders: 1 person, 16.67%
  6. Drug Ineffective: 1 person, 16.67%
  7. Duodenal Perforation (complication of duodenal ulcer): 1 person, 16.67%
  8. Erysipelas (bacterial skin infection): 1 person, 16.67%
  9. Fatigue (feeling of tiredness): 1 person, 16.67%
  10. Fever: 1 person, 16.67%

Common conditions people have *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 33.33%
  2. Depression: 2 people, 33.33%
  3. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 16.67%
  4. Psoriasis (immune-mediated disease that affects the skin): 1 person, 16.67%
  5. Pain: 1 person, 16.67%
  6. Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 16.67%
  7. Insomnia (sleeplessness): 1 person, 16.67%
  8. Fever: 1 person, 16.67%
  9. Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 16.67%
  10. Abdominal Pain: 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate sodium and have Acute pulmonary histoplasmosis?

Check whether Acute pulmonary histoplasmosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Acute pulmonary histoplasmosis and when was it recovered:

Expand to all the drugs that have ingredients of methotrexate sodium:

Alternative drugs to, pros and cons of Methotrexate sodium:

Common Methotrexate sodium side effects:

Browse all side effects of Methotrexate sodium:

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Acute pulmonary histoplasmosis treatments and more:

COVID vaccines that are related to Acute pulmonary histoplasmosis:

All the drugs that are associated with Acute pulmonary histoplasmosis:

All the conditions that are associated with Acute pulmonary histoplasmosis:

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate sodium) and Methotrexate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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