Methotrexate and Abdominal pain - from FDA reports

Abdominal pain is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Humira, and have Crohn's disease. This review analyzes which people have Abdominal pain with Methotrexate. It is created by eHealthMe based on reports of 231,270 people who have side effects when taking Methotrexate from FDA , and is updated regularly.

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On Apr, 25, 2018

231,270 people reported to have side effects when taking Methotrexate.
Among them, 4,105 people (1.77%) have Abdominal pain

Number of reports submitted per year:

Could Methotrexate cause Abdominal pain?

Time on Methotrexate when people have Abdominal pain *:

  • < 1 month: 35.98 %
  • 1 - 6 months: 14.39 %
  • 6 - 12 months: 9.43 %
  • 1 - 2 years: 12.66 %
  • 2 - 5 years: 14.89 %
  • 5 - 10 years: 8.19 %
  • 10+ years: 4.47 %

Gender of people who have Abdominal pain when taking Methotrexate *:

  • female: 72.33 %
  • male: 27.67 %

Age of people who have Abdominal pain when taking Methotrexate *:

  • 0-1: 0.23 %
  • 2-9: 5.63 %
  • 10-19: 11.84 %
  • 20-29: 5.95 %
  • 30-39: 7.06 %
  • 40-49: 13.53 %
  • 50-59: 22.69 %
  • 60+: 33.07 %

Top conditions involved for these people *:

  • Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 371 people, 9.04%
  • Pain: 232 people, 5.65%
  • High Blood Pressure: 204 people, 4.97%
  • Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 200 people, 4.87%
  • Preventive Health Care: 147 people, 3.58%

Top co-used drugs for these people *:

  • Humira: 934 people, 22.75%
  • Folic Acid: 863 people, 21.02%
  • Enbrel: 691 people, 16.83%
  • Prednisone: 645 people, 15.71%
  • Remicade: 390 people, 9.50%

Top other side effects for these people *:

  • Diarrhea: 998 people, 24.31%
  • Nausea (feeling of having an urge to vomit): 972 people, 23.68%
  • Nausea And Vomiting: 780 people, 19.00%
  • Fever: 624 people, 15.20%
  • Fatigue (feeling of tiredness): 496 people, 12.08%

* Approximation only. Some reports may have incomplete information.

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Related studies


Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 234,889 users)

Abdominal pain

Abdominal pain has been reported by people with birth control, crohn's disease, high blood pressure, pain (latest reports from 137,931 Abdominal pain patients).

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