Methotrexate and Abdominal pain - from FDA reports


Abdominal pain is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Humira, and have Crohn's disease. This study is created by eHealthMe based on reports of 289,603 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

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On Oct, 15, 2018

289,603 people reported to have side effects when taking Methotrexate.
Among them, 4,380 people (1.51%) have Abdominal pain


Number of reports submitted per year:

Could Methotrexate cause Abdominal pain?

Time on Methotrexate when people have Abdominal pain *:

Gender of people who have Abdominal pain when taking Methotrexate *:

  • female: 71.67 %
  • male: 28.33 %

Age of people who have Abdominal pain when taking Methotrexate *:

Top conditions involved for these people *:

  1. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 449 people, 10.25%
  2. Pain: 276 people, 6.30%
  3. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 246 people, 5.62%
  4. High Blood Pressure: 237 people, 5.41%
  5. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 176 people, 4.02%

Click here to view more results or personalize the results to your gender and age

Top co-used drugs for these people *:

  1. Humira: 1,088 people, 24.84%
  2. Folic Acid: 716 people, 16.35%
  3. Enbrel: 649 people, 14.82%
  4. Prednisone: 479 people, 10.94%
  5. Remicade: 371 people, 8.47%

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Top other side effects for these people *:

  1. Diarrhea: 1,245 people, 28.42%
  2. Nausea (feeling of having an urge to vomit): 1,093 people, 24.95%
  3. Nausea And Vomiting: 916 people, 20.91%
  4. Fever: 638 people, 14.57%
  5. Joint Pain: 608 people, 13.88%

Click here to view more results or personalize the results to your gender and age

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



Do you have Abdominal pain while taking Methotrexate?


You are not alone:




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What would happen?

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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