Methotrexate and Appendix disorder - a phase IV clinical study of FDA data

Summary:

We study 566,827 people who have side effects when taking Methotrexate. Appendix disorder is found, especially among people who are female, 60+ old, have been taking the drug for < 1 month, also take Enbrel and have Epicondylitis.

The phase IV clinical study analyzes which people take Methotrexate and have Appendix disorder. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 17, 2023

566,827 people reported to have side effects when taking Methotrexate.
Among them, 124 people (0.02%) have Appendix disorder.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is used in rheumatoid arthritis. Currently, eHealthMe is studying from 571,372 Methotrexate users.

What is Appendix disorder?

Appendix disorder is found to be associated with 632 drugs and 376 conditions by eHealthMe. Currently, we are studying 2,021 people who have Appendix disorder.

Number of Methotrexate and Appendix disorder reports submitted per year:

Could Methotrexate cause Appendix disorder?

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Appendix disorder?

Check whether Appendix disorder is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

Related studies

Methotrexate side effects by duration, gender and age:

Methotrexate side effects (571,372 reports)

Appendix disorder treatments and more:

Appendix disorder (2,021 reports)

Common drugs associated with Appendix disorder:

All the drugs that are associated with Appendix disorder:

Appendix disorder (632 drugs)

Common conditions associated with Appendix disorder:

Osteoporosis: 464 reports

All the conditions that are associated with Appendix disorder:

Appendix disorder (376 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.